Search Results - "Mason, Ralph P"

New frontiers and developing applications in 19F NMR by Yu, Jian-Xin, Hallac, Rami R, Chiguru, Srinivas, Mason, Ralph P

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Imaging beta-galactosidase activity in human tumor xenografts and transgenic mice using a chemiluminescent substrate by Liu, Li, Mason, Ralph P

“…Detection of enzyme activity or transgene expression offers potential insight into developmental biology, disease progression, and potentially personalized…”
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Energy transfer chemiluminescence for ratiometric pH imaging by An, Weiwei, Mason, Ralph P, Lippert, Alexander R

“…Chemiluminescence imaging offers a low background and high sensitivity approach to imaging analytes in living cells and animals. Intensity-based measurements…”
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Development of aliphatic biodegradable photoluminescent polymers by Yang, Jian, Zhang, Yi, Gautam, Santosh, Liu, Li, Dey, Jagannath, Chen, Wei, Mason, Ralph P, Serrano, Carlos A, Schug, Kevin A, Tang, Liping

“…None of the current biodegradable polymers can function as both implant materials and fluorescent imaging probes. The objective of this study was to develop…”
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Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors by Liu, Li, O'Kelly, Devin, Schuetze, Regan, Carlson, Graham, Zhou, Heling, Trawick, Mary Lynn, Pinney, Kevin G, Mason, Ralph P

“…Tumor vasculature proliferates rapidly, generally lacks pericyte coverage, and is uniquely fragile making it an attractive therapeutic target. A subset of…”
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Blood oxygenation level-dependent (BOLD) contrast magnetic resonance imaging (MRI) for prediction of breast cancer chemotherapy response: A pilot study by Jiang, Lan, Weatherall, Paul T., McColl, Roderick W., Tripathy, Debu, Mason, Ralph P.

“…Purpose: To determine whether a simple noninvasive method of assessing tumor oxygenation is feasible in the clinical setting and can provide useful,…”
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A scalable open-source MATLAB toolbox for reconstruction and analysis of multispectral optoacoustic tomography data by O’Kelly, Devin, Campbell, James, Gerberich, Jeni L., Karbasi, Paniz, Malladi, Venkat, Jamieson, Andrew, Wang, Liqiang, Mason, Ralph P.

“…Multispectral photoacoustic tomography enables the resolution of spectral components of a tissue or sample at high spatiotemporal resolution. With the…”
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Pten haploinsufficiency accelerates formation of high-grade astrocytomas by Kwon, Chang-Hyuk, Zhao, Dawen, Chen, Jian, Alcantara, Sheila, Li, Yanjiao, Burns, Dennis K, Mason, Ralph P, Lee, Eva Y-H P, Wu, Hong, Parada, Luis F

“…We previously reported that central nervous system (CNS) inactivation of Nf1 and p53 tumor suppressor genes in mice results in the development of low-grade to…”
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Evaluating online filtering algorithms to enhance dynamic multispectral optoacoustic tomography by O’Kelly, Devin, Guo, Yihang, Mason, Ralph P.

“…[Display omitted] •Simple α and αβ filters effectively suppress noise in dynamic spectral images.•A multispectral extension of the Shepp-Logan phantom was…”
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Comparison of optical and power Doppler ultrasound imaging for non-invasive evaluation of arsenic trioxide as a vascular disrupting agent in tumors by Alhasan, Mustafa K, Liu, Li, Lewis, Matthew A, Magnusson, Jennifer, Mason, Ralph P

“…Small animal imaging provides diverse methods for evaluating tumor growth and acute response to therapy. This study compared the utility of non-invasive…”
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The vascular disrupting agent combretastatin A-4 phosphate causes prolonged elevation of proteins involved in heme flux and function in resistant tumor cells by Dey, Sanchareeka, Kumari, Sharda, Kalainayakan, Sarada Preeta, Campbell, 3rd, James, Ghosh, Poorva, Zhou, Heling, FitzGerald, Keely E, Li, Maoping, Mason, Ralph P, Zhang, Li, Liu, Li

“…Vascular disrupting agents (VDAs) represent a promising class of anti-cancer drugs for solid tumor treatment. Here, we aim to better understand the mechanisms…”
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Tumor hypoxia: long ignored but now detectable and potentially actionable by Mason, Ralph P

“…Oxygen-enhanced MRI was successfully applied to 24 patients with HPV-associated oropharyngeal cancer. This prospective trial rigorously evaluated…”
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MR-CBCT image-guided system for radiotherapy of orthotopic rat prostate tumors by Chiu, Tsuicheng D, Arai, Tatsuya J, Campbell Iii, James, Jiang, Steve B, Mason, Ralph P, Stojadinovic, Strahinja

“…Multi-modality image-guided radiotherapy is the standard of care in contemporary cancer management; however, it is not common in preclinical settings due to…”
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Dynamic near-infrared optical imaging of 2-deoxyglucose uptake by intracranial glioma of athymic mice by Zhou, Heling, Luby-Phelps, Kate, Mickey, Bruce E, Habib, Amyn A, Mason, Ralph P, Zhao, Dawen

“…It is recognized that cancer cells exhibit highly elevated glucose metabolism compared to non-tumor cells. We have applied in vivo optical imaging to study…”
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Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents by Devkota, Laxman, Lin, Chen-Ming, Strecker, Tracy E., Wang, Yifan, Tidmore, Justin K., Chen, Zhi, Guddneppanavar, Rajsekhar, Jelinek, Christopher J., Lopez, Ramona, Liu, Li, Hamel, Ernest, Mason, Ralph P., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.

“…[Display omitted] Targeting tumor vasculature represents an intriguing therapeutic strategy in the treatment of cancer. In an effort to discover new vascular…”
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Oxygenation in cervical cancer and normal uterine cervix assessed using blood oxygenation level-dependent (BOLD) MRI at 3T by Hallac, Rami R., Ding, Yao, Yuan, Qing, McColl, Roderick W., Lea, Jayanthi, Sims, Robert D., Weatherall, Paul T., Mason, Ralph P.

“…Hypoxia is reported to be a biomarker for poor prognosis in cervical cancer. However, a practical noninvasive method is needed for the routine clinical…”
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Tubulin-destabilizing agent BPR0L075 induces vascular-disruption in human breast cancer mammary fat pad xenografts by Liu, Li, Beck, Haley, Wang, Xiaolei, Hsieh, Hsing-Pang, Mason, Ralph P, Liu, Xinli

“…BPR0L075, 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole, is a tubulin-binding agent that inhibits tubulin polymerization by binding to the…”
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Biodistribution of phosphodiester and phosphorothioate siRNA by BRAASCH, Dwaine A, PAROO, Zain, CONSTANTINESCU, Anca, GANG REN, ÖZ, Orhan K, MASON, Ralph P, COREY, David R

“…Short interfering RNAs (siRNAs) are valuable tools for analyzing protein function in mammalian cell culture. This success has led to high expectations for in…”
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Noninvasive Anatomical and Functional Imaging of Orthotopic Glioblastoma Development and Therapy using Multispectral Optoacoustic Tomography by Balasundaram, Ghayathri, Ding, Lu, Li, Xiuting, Attia, Amalina Binte Ebrahim, Dean-Ben, Xose Luis, Ho, Chris Jun Hui, Chandrasekharan, Prashant, Tay, Hui Chien, Lim, Hann Qian, Ong, Chee Bing, Mason, Ralph P., Razansky, Daniel, Olivo, Malini

“…PURPOSE: Here we demonstrate the potential of multispectral optoacoustic tomography (MSOT), a new non-invasive structural and functional imaging modality, to…”
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Vascular Imaging of Solid Tumors in Rats with a Radioactive Arsenic-Labeled Antibody that Binds Exposed Phosphatidylserine by JENNEWEIN, Marc, LEWIS, Matthew A, ANTICH, Peter P, HERMANNE, Alex, RÖSCH, Frank, MASON, Ralph P, THORPE, Philip E, DAWEN ZHAO, TSYGANOV, Edward, SLAVINE, Nikolai, JIN HE, WATKINS, Linda, KODIBAGKAR, Vikram D, O'KELLY, Sean, KULKARNI, Padmakar

“…Purpose: We recently reported that anionic phospholipids, principally phosphatidylserine, become exposed on the external surface of vascular endothelial cells…”
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