Search Results - "Mason, Malcolm D"

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation by WEBBER, Jason, STEADMAN, Robert, MASON, Malcolm D, TABI, Zsuzsanna, CLAYTON, Aled

“…There is a growing interest in the cell-cell communication roles in cancer mediated by secreted vesicles termed exosomes. In this study, we examined whether…”
Get full text

EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part II: Treatment of Relapsing, Metastatic, and Castration-Resistant Prostate Cancer by Cornford, Philip, Bellmunt, Joaquim, Bolla, Michel, Briers, Erik, De Santis, Maria, Gross, Tobias, Henry, Ann M, Joniau, Steven, Lam, Thomas B, Mason, Malcolm D, van der Poel, Henk G, van der Kwast, Theo H, Rouvière, Olivier, Wiegel, Thomas, Mottet, Nicolas

“…Abstract Objective To present a summary of the 2016 version of the European Association of Urology (EAU) – European Society for Radiotherapy & Oncology (ESTRO)…”
Get full text

Addition of docetaxel or bisphosphonates to standard of care in men with localised or metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data by Vale, Claire L, Dr, Burdett, Sarah, MSc, Rydzewska, Larysa H M, BSc, Albiges, Laurence, MD, Clarke, Noel W, Prof, Fisher, David, MSc, Fizazi, Karim, Prof, Gravis, Gwenaelle, MD, James, Nicholas D, Prof, Mason, Malcolm D, Prof, Parmar, Mahesh K B, Prof, Sweeney, Christopher J, MBBS, Sydes, Matthew R, CStat, Tombal, Bertrand, Prof, Tierney, Jayne F, PhD

“…Summary Background Results from large randomised controlled trials combining docetaxel or bisphosphonates with standard of care in hormone-sensitive prostate…”
Get full text

The Benefits and Harms of Different Extents of Lymph Node Dissection During Radical Prostatectomy for Prostate Cancer: A Systematic Review by Fossati, Nicola, Willemse, Peter-Paul M, Van den Broeck, Thomas, van den Bergh, Roderick C.N, Yuan, Cathy Yuhong, Briers, Erik, Bellmunt, Joaquim, Bolla, Michel, Cornford, Philip, De Santis, Maria, MacPepple, Ekelechi, Henry, Ann M, Mason, Malcolm D, Matveev, Vsevolod B, van der Poel, Henk G, van der Kwast, Theo H, Rouvière, Olivier, Schoots, Ivo G, Wiegel, Thomas, Lam, Thomas B, Mottet, Nicolas, Joniau, Steven

“…Abstract Context There is controversy regarding the therapeutic role of pelvic lymph node dissection (PLND) in patients undergoing radical prostatectomy for…”
Get full text

Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression by Clayton, Aled, Mitchell, J. Paul, Court, Jacquelyn, Linnane, Seamus, Mason, Malcolm D, Tabi, Zsuzsanna

“…NKG2D is an activating receptor for NK, NKT, CD8(+), and gammadelta(+) T cells, whose aberrant loss in cancer is a key mechanism of immune evasion. Soluble…”
Get full text

Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2 by CLAYTON, Aled, MITCHELL, J. Paul, COURT, Jacquelyn, MASON, Malcolm D, TABI, Zsuzsanna

“…Exosomes are nanometer-sized vesicles, secreted by normal and neoplastic cells. The outcome following interaction between the cellular immune system and…”
Get full text

Final Report of the Intergroup Randomized Study of Combined Androgen-Deprivation Therapy Plus Radiotherapy Versus Androgen-Deprivation Therapy Alone in Locally Advanced Prostate Cancer by Mason, Malcolm D, Parulekar, Wendy R, Sydes, Matthew R, Brundage, Michael, Kirkbride, Peter, Gospodarowicz, Mary, Cowan, Richard, Kostashuk, Edmund C, Anderson, John, Swanson, Gregory, Parmar, Mahesh K B, Hayter, Charles, Jovic, Gordana, Hiltz, Andrea, Hetherington, John, Sathya, Jinka, Barber, James B P, McKenzie, Michael, El-Sharkawi, Salah, Souhami, Luis, Hardman, P D John, Chen, Bingshu E, Warde, Padraig

“…We have previously reported that radiotherapy (RT) added to androgen-deprivation therapy (ADT) improves survival in men with locally advanced prostate cancer…”
Get full text

Proteomics Analysis of Cancer Exosomes Using a Novel Modified Aptamer-based Array (SOMAscanTM) Platform by Webber, Jason, Stone, Timothy C., Katilius, Evaldas, Smith, Breanna C., Gordon, Bridget, Mason, Malcolm D., Tabi, Zsuzsanna, Brewis, Ian A., Clayton, Aled

“…We have used a novel affinity-based proteomics technology to examine the protein signature of small secreted extracellular vesicles called exosomes. The…”
Get full text

Proteomics Analysis of Bladder Cancer Exosomes by Welton, Joanne L., Khanna, Sanjay, Giles, Peter J., Brennan, Paul, Brewis, Ian A., Staffurth, John, Mason, Malcolm D., Clayton, Aled

“…Exosomes are nanometer-sized vesicles, secreted by various cell types, present in biological fluids that are particularly rich in membrane proteins. Ex vivo…”
Get full text

Improving the TNM classification: Findings from a 10‐year continuous literature review by Webber, Colleen, Gospodarowicz, Mary, Sobin, Leslie H., Wittekind, Christian, Greene, Frederick L., Mason, Malcolm D., Compton, Carolyn, Brierley, James, Groome, Patti A

“…The Union for International Cancer Control's (UICC) TNM classification is a globally accepted system to describe the anatomic extent of malignant tumors. Since…”
Get full text

Active monitoring, radical prostatectomy, or radiotherapy for localised prostate cancer: study design and diagnostic and baseline results of the ProtecT randomised phase 3 trial by Lane, J Athene, PhD, Donovan, Jenny L, Prof, Davis, Michael, MSc, Walsh, Eleanor, MSc, Dedman, Daniel, MSc, Down, Liz, BSc, Turner, Emma L, PhD, Mason, Malcolm D, Prof, Metcalfe, Chris, PhD, Peters, Tim J, Prof, Martin, Richard M, PhD, Neal, David E, Prof, Hamdy, Freddie C, Prof

“…Summary Background Prostate cancer is a major public health problem with considerable uncertainties about the effectiveness of population screening and…”
Get full text

Can urinary exosomes act as treatment response markers in prostate cancer? by Mitchell, Paul J, Welton, Joanne, Staffurth, John, Court, Jacquelyn, Mason, Malcolm D, Tabi, Zsuzsanna, Clayton, Aled

“…Recently, nanometer sized vesicles (termed exosomes) have been described as a component of urine. Such vesicles may be a useful non-invasive source of markers…”
Get full text

Induction of heat shock proteins in B-cell exosomes by Clayton, Aled, Turkes, Attilla, Navabi, Hossein, Mason, Malcolm D, Tabi, Zsuzsanna

“…Exosomes are nanometer-sized vesicles secreted by a diverse range of live cells that probably have physiological roles in modulating cellular immunity. The…”
Get full text

Adjuvant therapy with oral sodium clodronate in locally advanced and metastatic prostate cancer: long-term overall survival results from the MRC PR04 and PR05 randomised controlled trials by Dearnaley, David P, Prof, Mason, Malcolm D, Prof, Parmar, Mahesh KB, Prof, Sanders, Karen, BSc, Sydes, Matthew R, MSc

“…Summary Background Bisphosphonates might modulate the development of symptomatic bone metastases in men with prostate cancer. The Medical Research Council…”
Get full text

Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis by YE, LIN, JIA, YONGNING, JI, KE, SANDERS, ANDREW J, XUE, KAN, JI, JIAFU, MASON, MALCOLM D, JIANG, WEN G

“…Traditional Chinese medicine (TCM) has been a major part of healthcare in China, and has extensively affected medicine and healthcare in surrounding countries…”
Get full text

Radioisotopes for the palliation of metastatic bone cancer: a systematic review by Finlay, Ilora G, Mason, Malcolm D, Shelley, Mike

“…Strontium-89 and samarium-153 are radioisotopes that are approved in the USA and Europe for the palliation of pain from metastatic bone cancer, whereas…”
Get more information

Intravesical gemcitabine therapy for non‐muscle invasive bladder cancer (NMIBC): a systematic review by Shelley, Mike D., Jones, Gabriel, Cleves, Anne, Wilt, Timothy J., Mason, Malcolm D., Kynaston, Howard G.

“…What's known on the subject? and What does the study add? The standard treatment for non‐muscle invasive bladder (NMIBC) is transurethral resection followed by…”
Get full text

Correction: YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells by Jiang, Wen G, Ye, Lin, Ruge, Fiona, Owen, Sioned, Martin, Tracey, Sun, Ping-Hui, Sanders, Andrew J, Lane, Jane, Satherley, Lucy, Weeks, Hoi P, Gao, Yong, Wei, Cong, Wu, Yiling, Mason, Malcolm D

Get full text

Tumor stroma-derived factors skew monocyte to dendritic cell differentiation toward a suppressive CD14+ PD-L1+ phenotype in prostate cancer by Spary, Lisa K, Salimu, Josephine, Webber, Jason P, Clayton, Aled, Mason, Malcolm D, Tabi, Zsuzsanna

“…Tumor-associated stromal myofibroblasts are essential for the progression and metastatic spread of solid tumors. Corresponding myeloid cell infiltration into…”
Get full text

Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial by Sydes, Matthew R, Parmar, Mahesh K B, Mason, Malcolm D, Clarke, Noel W, Amos, Claire, Anderson, John, de Bono, Johann, Dearnaley, David P, Dwyer, John, Green, Charlene, Jovic, Gordana, Ritchie, Alastair W S, Russell, J Martin, Sanders, Karen, Thalmann, George, James, Nicholas D

“…Systemic Therapy for Advanced or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) is a randomized controlled trial that follows a novel…”
Get full text