Search Results - "Mason, Kathy"

The Limitations of Model-Based Experimental Design and Parameter Estimation in Sloppy Systems by White, Andrew, Tolman, Malachi, Thames, Howard D, Withers, Hubert Rodney, Mason, Kathy A, Transtrum, Mark K

“…We explore the relationship among experimental design, parameter estimation, and systematic error in sloppy models. We show that the approximate nature of…”
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Interorganizational Knowledge Sharing to Establish Digital Health Learning Ecosystems: Qualitative Evaluation of a National Digital Health Transformation Program in England by Cresswell, Kathrin, Sheikh, Aziz, Franklin, Bryony Dean, Krasuska, Marta, The Nguyen, Hung, Hinder, Susan, Lane, Wendy, Mozaffar, Hajar, Mason, Kathy, Eason, Sally, Potts, Henry, Williams, Robin

“…Background The English Global Digital Exemplar (GDE) program is one of the first concerted efforts to create a digital health learning ecosystem across a…”
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Animal Models for Medical Countermeasures to Radiation Exposure by Williams, Jacqueline P., Brown, Stephen L., Georges, George E., Hauer-Jensen, Martin, Hill, Richard P., Huser, Amy K., Kirsch, David G., MacVittie, Thomas J., Mason, Kathy A., Medhora, Meetha M., Moulder, John E., Okunieff, Paul, Otterson, Mary F., Robbins, Michael E., Smathers, James B., McBride, William H.

“…Since September 11, 2001, there has been the recognition of a plausible threat from acts of terrorism, including radiological or nuclear attacks. A network of…”
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Neuroimmune mechanisms of behavioral alterations in a syngeneic murine model of human papilloma virus-related head and neck cancer by Vichaya, Elisabeth G, Vermeer, Daniel W, Christian, Diana L, Molkentine, Jessica M, Mason, Kathy A, Lee, John H, Dantzer, Robert

“…Highlights • Tumor inflammation is associated with increased liver and brain inflammation. • The tumor-induced a behavioral phenotype resembling mild fatigue…”
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Promoting inter-organisational knowledge sharing: A qualitative evaluation of England’s Global Digital Exemplar and Fast Follower Programme by Hinder, Susan, Cresswell, Kathrin, Sheikh, Aziz, Franklin, Bryony Dean, Krasuska, Marta, The Nguyen, Hung, Lane, Wendy, Mozaffar, Hajar, Mason, Kathy, Eason, Sally, Potts, Henry W. W, Williams, Robin

“…Background The Global Digital Exemplar (GDE) Programme was designed to promote the digitisation of hospital services in England. Selected provider…”
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MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation by Wang, Li, Mason, Kathy A., Ang, K. Kian, Buchholz, Thomas, Valdecanas, David, Mathur, Anjili, Buser-Doepner, Carolyn, Toniatti, Carlo, Milas, Luka

“…Summary The poly-(ADP-ribose) polymerase (PARP) inhibitor, MK-4827, is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor currently in phase I…”
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Rod Withers' Data are Available Online by Thames, Howard D., PhD, Hunter, Nancy R., BA, Mason, Kathy A., MA

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Theoretical and methodological considerations in evaluating large-scale health information technology change programmes by Cresswell, Kathrin, Sheikh, Aziz, Franklin, Bryony Dean, Krasuska, Marta, Nguyen, Hung The, Hinder, Susan, Lane, Wendy, Mozaffar, Hajar, Mason, Kathy, Eason, Sally, Potts, Henry W W, Williams, Robin

“…Attempts to achieve digital transformation across the health service have stimulated increasingly large-scale and more complex change programmes. These…”
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Nature's Return: An Environmental History of Congaree National Park by Mark Kinzer (review) by Mason, Kathy S

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Mitigation and Treatment of Radiation-Induced Thoracic Injury With a Cyclooxygenase-2 Inhibitor, Celecoxib by Hunter, Nancy R., MS, Valdecanas, David, BS, Liao, Zhongxing, MD, Milas, Luka, MD, Thames, Howard D., PhD, Mason, Kathy A., MS

“…Purpose To test whether a cyclooxygenase-2 inhibitor (celecoxib) could reduce mortality resulting from radiation-induced pneumonitis. Methods and Materials…”
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Use of the LQ model with large fraction sizes results in underestimation of isoeffect doses by Sheu, Tommy, Molkentine, Jessica, Transtrum, Mark K, Buchholz, Thomas A, Withers, Hubert Rodney, Thames, Howard D, Mason, Kathy A

“…Abstract Purpose To test the appropriateness of the linear-quadratic (LQ) model to describe survival of jejunal crypt clonogens after split doses with variable…”
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Sickness behavior induced by cisplatin chemotherapy and radiotherapy in a murine head and neck cancer model is associated with altered mitochondrial gene expression by Vichaya, Elisabeth G., Molkentine, Jessica M., Vermeer, Daniel W., Walker, Adam K., Feng, Rebekah, Holder, Gerard, Luu, Katherine, Mason, Ryan M., Saligan, Leo, Heijnen, Cobi J., Kavelaars, Annemieke, Mason, Kathy A., Lee, John H., Dantzer, Robert

“…•A murine model of cancer induces sickness behavior and inflammation.•Chemoradiation attenuates tumor-induced inflammation.•Chemoradiation does not attenuate…”
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Formative independent evaluation of a digital change programme in the English National Health Service: study protocol for a longitudinal qualitative study by Cresswell, Kathrin, Sheikh, Aziz, Dean Franklin, Bryony, Krasuska, Marta, Nguyen, Hung, Hinder, Susan, Lane, Wendy, Mozaffar, Hajar, Mason, Kathy, Eason, Sally, Potts, Henry, Williams, Robin

“…IntroductionMany countries are launching large-scale, digitally enabled change programmes as part of efforts to improve the quality, safety and efficiency of…”
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The Withers archive: Online availability of rod Wither’s data by Thames, Howard D, Hunter, N.R, Mason, Kathy A

“…Abstract The contents of the lab notebooks of H.R. Withers have been digitized and stored as 23 excel files, a total of approximately 45 megabytes. A procedure…”
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A high content clonogenic survival drug screen identifies mek inhibitors as potent radiation sensitizers for KRAS mutant non-small-cell lung cancer by Lin, Steven H, Zhang, Jing, Giri, Uma, Stephan, Clifford, Sobieski, Mary, Zhong, Ling, Mason, Kathy A, Molkentine, Jessica, Thames, Howard D, Yoo, Stephen S, Heymach, John V

“…Traditional clonogenic survival and high throughput colorimetric assays are inadequate as drug screens to identify novel radiation sensitizers. We developed a…”
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Driving digital health transformation in hospitals: a formative qualitative evaluation of the English Global Digital Exemplar programme by Krasuska, Marta, Williams, Robin, Sheikh, Aziz, Franklin, Bryony, Hinder, Susan, TheNguyen, Hung, Lane, Wendy, Mozaffar, Hajar, Mason, Kathy, Eason, Sally, Potts, Henry, Cresswell, Kathrin

“…BackgroundThere is currently a strong drive internationally towards creating digitally advanced healthcare systems through coordinated efforts at a national…”
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CpG plus radiotherapy: a review of preclinical works leading to clinical trial by Mason, Kathy A, Hunter, Nancy R

“…Studies performed three decades ago in our laboratory supported the hypothesis that radiation efficacy may be augmented by bacterial extracts that stimulate…”
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In Vivo Enhancement of Tumor Radioresponse by C225 Antiepidermal Growth Factor Receptor Antibody by MILAS, L, MASON, K, HUNTER, N, PETERSEN, S, YAMAKAWA, M, KIAN ANG, MENDELSOHN, J, ZHEN FAN

“…Overexpression of epidermal growth factor receptor (EGFR) has been correlated with tumor resistance to cytotoxic agents, including radiation (T. Akimoto et…”
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Preclinical evaluation of sunitinib, a multi-tyrosine kinase inhibitor, as a radiosensitizer for human prostate cancer by Brooks, Colin, Sheu, Tommy, Bridges, Kathleen, Mason, Kathy, Kuban, Deborah, Mathew, Paul, Meyn, Raymond

“…Many prostate cancers demonstrate an increased expression of growth factor receptors such as vascular endothelial growth factor receptor (VEGFR) and platelet…”
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Importance of maintenance therapy in C225-induced enhancement of tumor control by fractionated radiation by Milas, Luka, M.D., Ph.D, Fang, Fu-Min, M.D, Mason, Kathy A., M.Sc, Valdecanas, David, B.S, Hunter, Nancy, M.Sc, Koto, Masashi, M.D, Ang, K. Kian, M.D., Ph.D

“…Purpose: C225 strongly enhances tumor radioresponse when given concurrently with radiotherapy. We investigated whether additional therapeutic benefit could be…”
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