Search Results - "Mason, Jeremy W"

Water-Compatible Cycloadditions of Oligonucleotide-Conjugated Strained Allenes for DNA-Encoded Library Synthesis by Westphal, Matthias V, Hudson, Liam, Mason, Jeremy W, Pradeilles, Johan A, Zécri, Frédéric J, Briner, Karin, Schreiber, Stuart L

“…DNA-encoded libraries of small molecules are being explored extensively for the identification of binders in early drug-discovery efforts. Combinatorial…”
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Machine Learning on DNA-Encoded Library Count Data Using an Uncertainty-Aware Probabilistic Loss Function by Lim, Katherine S., Reidenbach, Andrew G., Hua, Bruce K., Mason, Jeremy W., Gerry, Christopher J., Clemons, Paul A., Coley, Connor W.

“…DNA-encoded library (DEL) screening and quantitative structure–activity relationship (QSAR) modeling are two techniques used in drug discovery to find novel…”
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DNA-encoded library-enabled discovery of proximity-inducing small molecules by Mason, Jeremy W., Chow, Yuen Ting, Hudson, Liam, Tutter, Antonin, Michaud, Gregory, Westphal, Matthias V., Shu, Wei, Ma, Xiaolei, Tan, Zher Yin, Coley, Connor W., Clemons, Paul A., Bonazzi, Simone, Berst, Frédéric, Briner, Karin, Liu, Shuang, Zécri, Frédéric J., Schreiber, Stuart L.

“…Small molecules that induce protein–protein associations represent powerful tools to modulate cell circuitry. We sought to develop a platform for the direct…”
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Rational Screening for Cooperativity in Small-Molecule Inducers of Protein–Protein Associations by Liu, Shuang, Tong, Bingqi, Mason, Jeremy W., Ostrem, Jonathan M., Tutter, Antonin, Hua, Bruce K., Tang, Sunny A., Bonazzi, Simone, Briner, Karin, Berst, Frédéric, Zécri, Frédéric J., Schreiber, Stuart L.

“…The hallmark of a molecular glue is its ability to induce cooperative protein–protein interactions, leading to the formation of a ternary complex, despite…”
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Stolonidiol: Synthesis, Target Identification, and Mechanism for Choline Acetyltransferase Activation by Mason, Jeremy W, Schmid, Cullen L, Bohn, Laura M, Roush, William R

“…Stolonidiol, a marine natural product, has been reported to potentiate the activity of choline acetyltransferase (ChAT), the enzyme that produces the…”
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Diversity-oriented synthesis encoded by deoxyoligonucleotides by Hudson, Liam, Mason, Jeremy W., Westphal, Matthias V., Richter, Matthieu J. R., Thielman, Jonathan R., Hua, Bruce K., Gerry, Christopher J., Xia, Guoqin, Osswald, Heather L., Knapp, John M., Tan, Zher Yin, Kokkonda, Praveen, Tresco, Ben I. C., Liu, Shuang, Reidenbach, Andrew G., Lim, Katherine S., Poirier, Jennifer, Capece, John, Bonazzi, Simone, Gampe, Christian M., Smith, Nichola J., Bradner, James E., Coley, Connor W., Clemons, Paul A., Melillo, Bruno, Hon, C. Suk-Yee, Ottl, Johannes, Dumelin, Christoph E., Schaefer, Jonas V., Faust, Ann Marie E., Berst, Frédéric, Schreiber, Stuart L., Zécri, Frédéric J., Briner, Karin

“…Diversity-oriented synthesis (DOS) is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, resulting in…”
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Xanthates as Synthetic Equivalents of Oxyacyl Radicals: Access to Lactones under Tin-Free Conditions by Davy, Jason A, Mason, Jeremy W, Moreau, Benoît, Wulff, Jeremy E

“…In addition to their utility in Barton–McCombie deoxygenations, xanthates can engage in 5-exo-trig radical cyclizations to afford lactones after oxidative…”
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The de-guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase by Bromba, Caleb M., Mason, Jeremy W., Brant, Michael G., Chan, Tracy, Lunke, Martine D., Petric, Martin, Boulanger, Martin J., Wulff, Jeremy E.

“…The guanidine function in the potent neuraminidase inhibitor peramivir was included early on in the drug design process, and examination of X-ray structural…”
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Structural characterization and epitope mapping of the glutamic acid/alanine-rich protein from Trypanosoma congolense: defining assembly on the parasite cell surface by Loveless, Bianca C, Mason, Jeremy W, Sakurai, Tatsuya, Inoue, Noboru, Razavi, Morteza, Pearson, Terry W, Boulanger, Martin J

“…Trypanosoma congolense is an African trypanosome that causes serious disease in cattle in Sub-Saharan Africa. The four major life cycle stages of T. congolense…”
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Structural Characterization and Epitope Mapping of the Glutamic Acid/Alanine-rich Protein from Trypanosoma congolense by Loveless, Bianca C., Mason, Jeremy W., Sakurai, Tatsuya, Inoue, Noboru, Razavi, Morteza, Pearson, Terry W., Boulanger, Martin J.

“…Trypanosoma congolense is an African trypanosome that causes serious disease in cattle in Sub-Saharan Africa. The four major life cycle stages of T. congolense…”
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Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides by Hudson, Liam, Mason, Jeremy W., Westphal, Matthias V., Richter, Matthieu J. R., Thielman, Jonathan R., Hua, Bruce K., Gerry, Christopher J., Xia, Guoqin, Osswald, Heather L., Knapp, John M., Tan, Zher Yin, Kokkonda, Praveen, Tresco, Ben I. C., Liu, Shuang, Reidenbach, Andrew G., Lim, Katherine S., Poirier, Jennifer, Capece, John, Bonazzi, Simone, Gampe, Christian M., Smith, Nichola J., Bradner, James E., Coley, Connor W., Clemons, Paul A., Melillo, Bruno, Hon, C. Suk-Yee, Ottl, Johannes, Dumelin, Christoph E., Schaefer, Jonas V., Faust, Ann Marie E., Berst, Frédéric, Schreiber, Stuart L., Zécri, Frédéric J., Briner, Karin

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Correcting Metabolic Disturbances in Disease: Part 1 – Enhancing Acetylcholine Synthesis in Alzheimer’s Disease Part 2 – Approach towards Depleting Lipid Building-Blocks In Cardiovascular Disease by Mason, Jeremy W

“…The following dissertation describes two projects guided by the over-arching theme: can we correct metabolic disturbances found in disease states to effect…”
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Machine learning on DNA-encoded library count data using an uncertainty-aware probabilistic loss function by Lim, Katherine S, Reidenbach, Andrew G, Hua, Bruce K, Mason, Jeremy W, Gerry, Christopher J, Clemons, Paul A, Coley, Connor W

“…DNA-encoded library (DEL) screening and quantitative structure-activity relationship (QSAR) modeling are two techniques used in drug discovery to find small…”
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