Search Results - "Mason, Helen D."

Anti-Müllerian hormone and polycystic ovary syndrome: a mountain too high? by Pellatt, Laura, Rice, Suman, Mason, Helen D

“…Anti-Müllerian hormone (AMH) was initially thought to be produced solely by the foetal male during sexual differentiation to promote regression of the…”
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Anti-Müllerian hormone reduces follicle sensitivity to follicle-stimulating hormone in human granulosa cells by Pellatt, Laura, Ph.D, Rice, Suman, Ph.D, Dilaver, Nafi, B.Sc, Heshri, Amira, B.Sc, Galea, Raymond, M.B., B.S, Brincat, Mark, Ph.D, Brown, Kristy, Ph.D, Simpson, Evan R., Ph.D, Mason, Helen D., Ph.D

“…Objective To determine that anti-Müllerian hormone (AMH) has been shown to inhibits E2 production in rodents and in luteinized granulosa cells (GC). We…”
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Metformin Inhibits Follicle-Stimulating Hormone (FSH) Action in Human Granulosa Cells: Relevance to Polycystic Ovary Syndrome by Rice, Suman, Elia, Androulla, Jawad, Zara, Pellatt, Laura, Mason, Helen D

“…Background: Women with anovulatory polycystic ovary syndrome (PCOS) are generally insulin-resistant and as a consequence are often treated with the biguanide…”
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The regulation and signalling of anti-Müllerian hormone in human granulosa cells: relevance to polycystic ovary syndrome by Dilaver, Nafi, Pellatt, Laura, Jameson, Ella, Ogunjimi, Michael, Bano, Gul, Homburg, Roy, D Mason, Helen, Rice, Suman

“…Abstract STUDY QUESTION What prevents the fall in anti-Müllerian hormone (AMH) levels in polycystic ovary syndrome (PCOS) and what are the consequences of this…”
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Health-related quality of life in women with polycystic ovary syndrome: A comparison with the general population using the Polycystic Ovary Syndrome Questionnaire (PCOSQ) and the Short Form-36 (SF-36) by Coffey, Sean, Bano, Gul, Mason, Helen D.

“…Background. We examined whether women with polycystic ovary syndrome (PCOS) have poorer health-related quality of life (HRQoL) than women in the general…”
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Phytoestrogens and their low dose combinations inhibit mRNA expression and activity of aromatase in human granulosa-luteal cells by Rice, Suman, Mason, Helen D., Whitehead, Saffron A.

“…There is evidence that certain phytoestrogens inhibit aromatase, the enzyme that converts androgens to oestrogens. Kinetic studies in cell-free preparations…”
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Linkage of regulators of TGF‐β activity in the fetal ovary to polycystic ovary syndrome by Hatzirodos, Nicholas, Bayne, Rosemary A., Irving‐Rodgers, Helen F., Hummitzsch, Katja, Sabatier, Laetitia, Lee, Sam, Bonner, Wendy, Gibson, Mark A., Rainey, William E., Carr, Bruce R., Mason, Helen D., Reinhardt, Dieter P., Anderson, Richard A., Rodgers, Raymond J.

“…ABSTRACT Although not often discussed, the ovaries of women with polycystic ovary syndrome (PCOS) show all the hallmarks of increased TGF‐β activity, with…”
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Insulin-Like Growth Factor (IGF)-Independent Effects of IGF Binding Protein-4 on Human Granulosa Cell Steroidogenesis by WRIGHT, Rebecca J, HOLLY, Jeffrey M. P, GALEA, Ray, BRINCAT, Mark, MASON, Helen D

“…The ovarian insulin-like growth factor (IGF)/IGF binding protein (IGFBP) system operates to permit maximal stimulation of steroidogenesis in the dominant…”
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Ovarian 11β-Hydroxysteroid Dehydrogenase (11βHSD) Activity Is Suppressed in Women With Anovulatory Polycystic Ovary Syndrome (PCOS): Apparent Role for Ovarian Androgens by Michael, Anthony E, Glenn, Christine, Wood, Peter J, Webb, Rachel J, Pellatt, Laura, Mason, Helen D

“…Context: Altered hepatic cortisol-cortisone metabolism by type 1 11β-hydroxysteroid dehydrogenase (11βHSD1) has previously been linked with polycystic ovary…”
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Lack of Serum Anti-Mullerian Hormone Responses After Recombinant Human Chorionic Gonadotropin Stimulation in Women With Polycystic Ovary Syndrome by Cook-Andersen, Heidi, Chuan, Sandy S, Maas, Kevin, Rosencrantz, Marcus A, Su, H. Irene, Lawson, Mark, Mason, Helen D, Chang, R. Jeffrey

“…Context: Polycystic ovary syndrome (PCOS) is an anovulatory disorder characterized by excess androgen production and increased LH secretion. Serum…”
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Selection of gonadotrophin surge attenuating factor phage antibodies by bioassay by Sorsa-Leslie, Tarja, Mason, Helen D, Harris, William J, Fowler, Paul A

“…We aimed to combine the generation of "artificial" antibodies with a rat pituitary bioassay as a new strategy to overcome 20 years of difficulties in the…”
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Genetic and gene expression analyses of the polycystic ovary syndrome candidate gene fibrillin-3 and other fibrillin family members in human ovaries by Prodoehl, Mark J., Hatzirodos, Nicholas, Irving-Rodgers, Helen F., Zhao, Zhen Z., Painter, Jodie N., Hickey, Theresa E., Gibson, Mark A., Rainey, William E., Carr, Bruce R., Mason, Helen D., Norman, Robert J., Montgomery, Grant W., Rodgers, Raymond J.

“…Several studies have demonstrated an association between polycystic ovary syndrome (PCOS) and the dinucleotide repeat microsatellite marker D19S884, which is…”
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Phenotypes of the ovarian follicular basal lamina predict developmental competence of oocytes by Irving-Rodgers, Helen F., Morris, Stephanie, Collett, Rachael A., Peura, Teija T., Davy, Margaret, Thompson, Jeremy G., Mason, Helen D., Rodgers, Raymond J.

“…BACKGROUND The ovarian follicular basal lamina underlies the epithelial membrana granulosa and maintains the avascular intra-follicular compartment. Additional…”
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Pelvic ultrasonography in anorexia nervosa: what the clinician should ask the radiologist and how to use the information provided by Mason, Helen D., Key, Adrienne, Allan, Rosemary, Lask, Bryan

“…Pelvic ultrasonography is generally regarded as the gold standard for determination of pelvic maturity and hence the need for further weight gain in patients…”
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Extracellular matrix of the human cyclic corpus luteum by Irving-Rodgers, Helen F., Friden, Barbro E., Morris, Stephanie E., Mason, Helen D., Brannstrom, Mats, Sekiguchi, Kiyotoshi, Sanzen, Noriko, Sorokin, Lydia M., Sado, Yoshikazu, Ninomiya, Yoshifumi, Rodgers, Raymond J.

“…Extracellular matrix regulates many cellular processes likely to be important for development and regression of corpora lutea. Therefore, we identified the…”
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Ovarian gonadotrophin surge-attenuating factor (GnSAF): where are we after 20 years of research? by Fowler, PA, Sorsa-Leslie, T, Harris, W, Mason, HD

“…When gonadotrophin-stimulated IVF methods were being developed in the 1970s and 1980s, understanding of the physiology of FSH improved. In addition to its…”
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Relationship between follicle size and gonadotrophin surge attenuating factor (GnSAF) bioactivity during spontaneous cycles in women by Fowler, Paul A., Sorsa, Tarja, Harris, William J., Knight, Philip G., Mason, Helen D.

“…BACKGROUND: We have previously demonstrated that follicles ≤11 mm diameter from women undergoing IVF contain higher concentrations of gonadotrophin surge…”
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A 60–66 kDa protein with gonadotrophin surge attenuating factor bioactivity is produced by human ovarian granulosa cells by Fowler, Paul A., Sorsa-Leslie, Tarja, Cash, Phillip, Dunbar, Bryan, Melvin, William, Wilson, Yvonne, Mason, Helen D., Harris, William

“…We aimed to confirm the ovarian site of gonadotrophin surge-attenuating factor (GnSAF) production and produce granulosa/luteal cell-conditioned medium (G/LCM)…”
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Developmentally Regulated Responses of Human Granulosa Cells to Insulin-Like Growth Factors (IGFs):IGF-I and IGF-II Action Mediated Via the Type-I IGF Receptor1 by Willis, Debbie S, Mason, Helen D, Watson, Hazel, Franks, Stephen

“…In experimental animal models, insulin-like growth factors (IGFs) have been found to be more potent stimulators of ovarian function than insulin. In human…”
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Premature response to luteinizing hormone of granulosa cells from anovulatory women with polycystic ovary syndrome : Relevance to mechanism of anovulation by WILLIS, D. S, WATSON, H, MASON, H. D, GALEA, R, BRINCAT, M, FRANKS, S

“…Polycystic ovary syndrome is the most common cause of anovulatory infertility. Anovulation in polycystic ovary syndrome is characterized by the failure of…”
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