Search Results - "Mason, G F"

Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments by Krystal, J H, Sanacora, G, Blumberg, H, Anand, A, Charney, D S, Marek, G, Epperson, C N, Goddard, A, Mason, G F

“…Glutamate and gamma-amino butyric acid (GABA) systems are emerging as targets for development of medications for mood disorders. There is increasing…”
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Phosphorylation of 20S proteasome alpha subunit C8 (alpha7) stabilizes the 26S proteasome and plays a role in the regulation of proteasome complexes by gamma-interferon by Bose, Suchira, Stratford, Fiona L L, Broadfoot, Kerry I, Mason, Grant G F, Rivett, A Jennifer

“…In animal cells there are several regulatory complexes which interact with 20S proteasomes and give rise to functionally distinct proteasome complexes…”
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Spectroscopic imaging of glutamate C4 turnover in human brain by Pan, J.W., Stein, D.T., Telang, F., Lee, J.H., Shen, J., Brown, P., Cline, G., Mason, G.F., Shulman, G.I., Rothman, D.L., Hetherington, H.P.

“…One‐dimensional spectroscopic imaging of 13C‐4‐glutamate turnover is performed in the human brain with a 6 cc nominal voxel resolution at 4T. Data were…”
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Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR by Mason, G F, Gruetter, R, Rothman, D L, Behar, K L, Shulman, R G, Novotny, E J

“…13C isotopic tracer data previously obtained by 13C nuclear magnetic resonance in the human brain in vivo were analyzed using a mathematical model to determine…”
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Dependence of Oxygen Delivery on Blood Flow in Rat Brain: A 7 Tesla Nuclear Magnetic Resonance Study by Hyder, Fahmeed, Kennan, Richard P., Kida, Ikuhiro, Mason, Graeme F., Behar, Kevin L., Rothman, Douglas

“…Magnetic resonance imaging (MRI) and spectroscopy (MRS) were used at a magnetic field strength of 7 T to measure CBF and CMRO2 in the sensorimotor cortex of…”
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NMR determination of the TCA cycle rate and alpha-ketoglutarate/glutamate exchange rate in rat brain by Mason, G F, Rothman, D L, Behar, K L, Shulman, R G

“…A mathematical model of cerebral glucose metabolism was developed to analyze the isotopic labeling of carbon atoms C4 and C3 of glutamate following an…”
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The rate of turnover of cortical GABA from [1-13C]glucose is reduced in rats treated with the GABA-transaminase inhibitor vigabatrin (γ-vinyl GABA) by MANOR, D, ROTHMAN, D. L, MASON, G. F, HYDER, F, PETROFF, O. A. C, BEHAR, K. L

“…Brain GABA levels rise and plateau following prolonged administration of the irreversible GABA-transaminase inhibitor vigabatrin (gamma-vinylGABA). Recently it…”
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A novel k-space trajectory measurement technique by Zhang, Y, Hetherington, H P, Stokely, E M, Mason, G F, Twieg, D B

“…A new k-space trajectory measurement technique is proposed and demonstrated. This technique measures the k-space trajectory, in seconds, using only a few…”
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Biological and clinical MRS at ultra-high field by Hetherington, H. P., Pan, J. W., Chu, W.-J., Mason, G. F., Newcomer, B. R.

“…The advantages of performing spectroscopic studies at higher field strengths include increased SNR, improved spectral resolution for J‐coupled resonances, and…”
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A method to measure arbitrary k-space trajectories for rapid MR imaging by Mason, G F, Harshbarger, T, Hetherington, H P, Zhang, Y, Pohost, G M, Twieg, D B

“…A method to measure arbitrary k-space trajectories was developed to compensate for nonideal gradient performance during rapid magnetic resonance (MR) imaging…”
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Spectroscopic imaging of human brain glutamate by water-suppressed J-refocused coherence transfer at 4.1 T by Pan, J W, Mason, G F, Pohost, G M, Hetherington, H P

“…The authors reported the development and implementation of a water-suppressed J-refocused coherence transfer sequence to observe glutamate in human brain at…”
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Stoichiometric Coupling of Brain Glucose Metabolism and Glutamatergic Neuronal Activity by Sibson, Nicola R., Dhankhar, Ajay, Mason, Graeme F., Rothman, Douglas L., Behar, Kevin L., Shulman, Robert G.

“…To determine the relationship between cerebral Glc metabolism and glutamatergic neuronal function, we used13C NMR spectroscopy to measure, simultaneously, the…”
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Sex, GABA, and nicotine: The impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy by Epperson, C. Neill, O’Malley, Stephanie, Czarkowski, Kathryn A., Gueorguieva, Ralitza, Jatlow, Peter, Sanacora, Gerard, Rothman, Douglas L., Krystal, John H., Mason, Graeme F.

“…Given that nicotine modulates amino acid neurotransmission, we sought to examine the impact of nicotine on cortical γ-aminobutyric acid (GABA) levels in male…”
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NMR determination of intracerebral glucose concentration and transport kinetics in rat brain by Mason, G F, Behar, K L, Rothman, D L, Shulman, R G

“…The concentration of intracerebral glucose as a function of plasma glucose concentration was measured in rats by 13C NMR spectroscopy. Measurements were made…”
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Cortical Gamma-Aminobutyric Acid Levels and the Recovery from Ethanol Dependence: Preliminary Evidence of Modification by Cigarette Smoking by Mason, Graeme F., Petrakis, Ismene L., de Graaf, Robin A., Gueorguieva, Ralitza, Guidone, Elizabeth, Coric, Vladimir, Epperson, C. Neill, Rothman, Douglas L., Krystal, John H.

“…Gamma-aminobutyric acid (GABA)ergic adaptations contribute to the neurobiology of ethanol dependence and withdrawal. Clinical data suggest that tobacco smoking…”
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Detection of brain glutamate and glutamine in spectroscopic images at 4.1 T by Mason, G F, Pan, J W, Ponder, S L, Twieg, D B, Pohost, G M, Hetherington, H P

“…Brain glutamate and glutamine were detected in healthy human volunteers in spectroscopic images with a nominal voxel size of 2.25 cm3 at an echo time of 15 ms…”
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Turnover of human muscle glycogen with low-intensity exercise by Price, T B, Taylor, R, Mason, G F, Rothman, D L, Shulman, G I, Shulman, R G

“…To determine whether glycogen turnover occurs during prolonged low-intensity exercise, five subjects performed plantar flexion of the right leg at 15% MVC for…”
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In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate–glutamine cycling by Sibson, N R, Dhankhar, A, Mason, G F, Behar, K L, Rothman, D L, Shulman, R G

“…The cerebral tricarboxylic acid (TCA) cycle rate and the rate of glutamine synthesis were measured in rats in vivo under normal physiological and…”
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Reduced Cortical γ-Aminobutyric Acid Levels in Depressed Patients Determined by Proton Magnetic Resonance Spectroscopy by Sanacora, Gerard, Mason, Graeme F, Rothman, Douglas L, Behar, Kevin L, Hyder, Fahmeed, Petroff, Ognen A. C, Berman, Robert M, Charney, Dennis S, Krystal, John H

“…BACKGROUND Several lines of emerging evidence suggest that dysfunction of γ-aminobutyric acid (GABA) systems is associated with major depression. However,…”
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Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD(67) protein by Mason, G F, Martin, D L, Martin, S B, Manor, D, Sibson, N R, Patel, A, Rothman, D L, Behar, K L

“…gamma-Aminobutyric acid (GABA) synthesis in the brain is mediated by two major isoforms of glutamic acid decarboxylase, GAD(65) and GAD(67). The contribution…”
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