Search Results - "Mason, Frank M."

Apical domain polarization localizes actin–myosin activity to drive ratchet-like apical constriction by Mason, Frank M., Tworoger, Michael, Martin, Adam C.

“…Apical constriction promotes epithelia folding, which changes tissue architecture. During Drosophila gastrulation, mesoderm cells exhibit repeated contractile…”
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SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma by Chiang, Yun-Chen, Park, In-Young, Terzo, Esteban A, Tripathi, Durga Nand, Mason, Frank M, Fahey, Catherine C, Karki, Menuka, Shuster, Charles B, Sohn, Bo-Hwa, Chowdhury, Pratim, Powell, Reid T, Ohi, Ryoma, Tsai, Yihsuan S, de Cubas, Aguirre A, Khan, Abid, Davis, Ian J, Strahl, Brian D, Parker, Joel S, Dere, Ruhee, Walker, Cheryl L, Rathmell, W Kimryn

“…Loss of the short arm of chromosome 3 (3p) occurs early in >95% of clear cell renal cell carcinoma (ccRCC). Nearly ubiquitous 3p loss in ccRCC suggests…”
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Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer by Hanna, Ann, Nixon, Mellissa J, Estrada, M Valeria, Sanchez, Violeta, Sheng, Quanhu, Opalenik, Susan R, Toren, Abigail L, Bauer, Joshua, Owens, Phillip, Mason, Frank M, Cook, Rebecca S, Sanders, Melinda E, Arteaga, Carlos L, Balko, Justin M

“…Deregulated signaling pathways are a hallmark feature of oncogenesis and driver of tumor progression. Dual specificity protein phosphatase 4 (DUSP4) is a…”
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Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition by Howard, Gregory Caleb, Wang, Jing, Rose, Kristie L, Jones, Camden, Patel, Purvi, Tsui, Tina, Florian, Andrea C, Vlach, Logan, Lorey, Shelly L, Grieb, Brian C, Smith, Brianna N, Slota, Macey J, Reynolds, Elizabeth M, Goswami, Soumita, Savona, Michael R, Mason, Frank M, Lee, Taekyu, Fesik, Stephen, Liu, Qi, Tansey, William P

“…The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for cancer drug discovery, with most efforts blocking an arginine-binding…”
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CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation by Beckermann, Kathryn E, Hongo, Rachel, Ye, Xiang, Young, Kirsten, Carbonell, Katie, Healey, Diana C Contreras, Siska, Peter J, Barone, Sierra, Roe, Caroline E, Smith, Christof C, Vincent, Benjamin G, Mason, Frank M, Irish, Jonathan M, Rathmell, W Kimryn, Rathmell, Jeffrey C

“…Metabolic reprogramming dictates the fate and function of stimulated T cells, yet these pathways can be suppressed in T cells in tumor microenvironments. We…”
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Crumbling under Pressure by Mason, Frank M., Martin, Adam C.

“…In order for an organism to maintain its form, it must be able to withstand physical perturbation, including the pull of gravity. A recent study in Nature from…”
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RhoA GTPase inhibition organizes contraction during epithelial morphogenesis by Mason, Frank M, Xie, Shicong, Vasquez, Claudia G, Tworoger, Michael, Martin, Adam C

“…During morphogenesis, contraction of the actomyosin cytoskeleton within individual cells drives cell shape changes that fold tissues. Coordination of…”
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Actomyosin Pulsing in Tissue Integrity Maintenance during Morphogenesis by Coravos, Jonathan S, Mason, Frank M, Martin, Adam C

“…The actomyosin cytoskeleton is responsible for many changes in cell and tissue shape. For a long time, the actomyosin cytoskeleton has been known to exhibit…”
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The mitochondrial fission protein DRP1 influences memory CD8+ T cell formation and function by Stevens, Marissa G, Mason, Frank M, Bullock, Timothy N J

“…Pharmacological methods for promoting mitochondrial elongation suggest that effector T cells can be altered to support a memory T cell-like metabolic state…”
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Dynamics of hydraulic and contractile wave-mediated fluid transport during Drosophila oogenesis by Alsous, Jasmin Imran, Romeo, Nicolas, Jackson, Jonathan A., Mason, Frank M., Dunkel, Jörn, Martin, Adam C.

“…From insects to mice, oocytes develop within cysts alongside nurse-like sister germ cells. Prior to fertilization, the nurse cells’ cytoplasmic contents are…”
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Molecular determinants for α-tubulin methylation by SETD2 by Kearns, Sarah, Mason, Frank M., Rathmell, W. Kimryn, Park, In Young, Walker, Cheryl, Verhey, Kristen J., Cianfrocco, Michael A.

“…Post-translational modifications to tubulin are important for many microtubule-based functions inside cells. It was recently shown that methylation of tubulin…”
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Loss of Gα12/13 exacerbates apical area dependence of actomyosin contractility by Xie, Shicong, Mason, Frank M, Martin, Adam C

“…During development, coordinated cell shape changes alter tissue shape. In the Drosophila ventral furrow and other epithelia, apical constriction of hundreds of…”
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Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma by Siska, Peter J, Beckermann, Kathryn E, Mason, Frank M, Andrejeva, Gabriela, Greenplate, Allison R, Sendor, Adam B, Chiang, Yun-Chen J, Corona, Armando L, Gemta, Lelisa F, Vincent, Benjamin G, Wang, Richard C, Kim, Bumki, Hong, Jiyong, Chen, Chiu-Lan, Bullock, Timothy N, Irish, Jonathan M, Rathmell, W Kimryn, Rathmell, Jeffrey C

“…Cancer cells can inhibit effector T cells (Teff) through both immunomodulatory receptors and the impact of cancer metabolism on the tumor microenvironment…”
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SETD2 safeguards the genome against isochromosome formation by Mason, Frank M, Kounlavong, Emily S, Tebeje, Anteneh T, Dahiya, Rashmi, Guess, Tiffany, Khan, Abid, Vlach, Logan, Norris, Stephen R, Lovejoy, Courtney A, Dere, Ruhee, Strahl, Brian D, Ohi, Ryoma, Ly, Peter, Walker, Cheryl Lyn, Rathmell, W Kimryn

“…Isochromosomes are mirror-imaged chromosomes with simultaneous duplication and deletion of genetic material which may contain two centromeres to create…”
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Tuning cell shape change with contractile ratchets by Mason, Frank M, Martin, Adam C

“…Throughout the lifespan of an organism, shape changes are necessary for cells to carry out their essential functions. Nowhere is this more dramatic than…”
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Bi-modal Regulation of a Formin by srGAP2 by Mason, Frank M., Heimsath, Ernest G., Higgs, Henry N., Soderling, Scott H.

“…The maintenance of rapid and efficient actin dynamics in vivo requires coordination of filament assembly and disassembly. This regulation requires temporal and…”
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The Huntingtin-interacting protein SETD2/HYPB is an actin lysine methyltransferase by Seervai, Riyad N H, Jangid, Rahul K, Karki, Menuka, Tripathi, Durga Nand, Jung, Sung Yun, Kearns, Sarah E, Verhey, Kristen J, Cianfrocco, Michael A, Millis, Bryan A, Tyska, Matthew J, Mason, Frank M, Rathmell, W Kimryn, Park, In Young, Dere, Ruhee, Walker, Cheryl Lyn

“…The methyltransferase SET domain-containing 2 (SETD2) was originally identified as Huntingtin (HTT) yeast partner B. However, a SETD2 function associated with…”
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Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy by Rawat, Vipin, DeLear, Patrick, Prashanth, Prarthana, Ozgurses, Mete Emir, Tebeje, Anteneh, Burns, Philippa A, Conger, Kelly O, Solís, Christopher, Hasnain, Yasir, Novikova, Anna, Endress, Jennifer E, González-Sánchez, Paloma, Dong, Wentao, Stephanopoulos, Greg, DeNicola, Gina M, Harris, Isaac S, Sept, David, Mason, Frank M, Coloff, Jonathan L

“…The nonphysiological nutrient levels found in traditional culture media have been shown to affect numerous aspects of cancer cell physiology, including how…”
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Subset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation by Heintzman, Darren R, Sinard, Rachael C, Fisher, Emilie L, Ye, Xiang, Patterson, Andrew R, Elasy, Joel H, Voss, Kelsey, Chi, Channing, Sugiura, Ayaka, Rodriguez-Garcia, Gabriel J, Chowdhury, Nowrin U, Arner, Emily N, Krystoviak, Evan S, Mason, Frank M, Toudji, Yasmine T, Steiner, KayLee K, Khan, Wasay, Olson, Lana M, Jones, Angela L, Hong, Hanna S, Bass, Lindsay, Beier, Katherine L, Deng, Wentao, Lyssiotis, Costas A, Newcomb, Dawn C, Bick, Alexander G, Rathmell, W Kimryn, Wilson, John T, Rathmell, Jeffrey C

“…Heat is a cardinal feature of inflammation, yet its impacts on immune cells remain uncertain. We show that moderate-grade fever temperatures (39°C) increased…”
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SH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexes by Okada, Hirokazu, Uezu, Akiyoshi, Mason, Frank M, Soderblom, Erik J, Moseley, 3rd, M Arthur, Soderling, Scott H

“…Rho family GAPs [guanosine triphosphatase (GTPase) activating proteins] negatively regulate Rho family GTPase activity and therefore modulate signaling events…”
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