Search Results - "Mason, Clinton C"

BCR-ABL1 compound mutations in tyrosine kinase inhibitor–resistant CML: frequency and clonal relationships by Khorashad, Jamshid S., Kelley, Todd W., Szankasi, Philippe, Mason, Clinton C., Soverini, Simona, Adrian, Lauren T., Eide, Christopher A., Zabriskie, Matthew S., Lange, Thoralf, Estrada, Johanna C., Pomicter, Anthony D., Eiring, Anna M., Kraft, Ira L., Anderson, David J., Gu, Zhimin, Alikian, Mary, Reid, Alistair G., Foroni, Letizia, Marin, David, Druker, Brian J., O'Hare, Thomas, Deininger, Michael W.

“…BCR-ABL1 compound mutations can confer high-level resistance to imatinib and other ABL1 tyrosine kinase inhibitors (TKIs). The third-generation ABL1 TKI…”
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Early Renal Function Decline in Type 2 Diabetes by Pavkov, Meda E, Knowler, William C, Lemley, Kevin V, Mason, Clinton C, Myers, Bryan D, Nelson, Robert G

“…Early decline in GFR may reflect progressive kidney disease in type 1 diabetes, but its predictive value in type 2 diabetes is uncertain. In this longitudinal…”
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shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance by Khorashad, Jamshid S., Eiring, Anna M., Mason, Clinton C., Gantz, Kevin C., Bowler, Amber D., Redwine, Hannah M., Yu, Fan, Kraft, Ira L., Pomicter, Anthony D., Reynolds, Kimberly R., Iovino, Anthony J., Zabriskie, Matthew S., Heaton, William L., Tantravahi, Srinivas K., Kauffman, Michael, Shacham, Sharon, Chenchik, Alex, Bonneau, Kyle, Ullman, Katharine S., O'Hare, Thomas, Deininger, Michael W.

“…The mechanisms underlying tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia (CML) patients lacking explanatory BCR-ABL1 kinase domain…”
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Progression to Type 2 Diabetes Characterized by Moderate Then Rapid Glucose Increases by MASON, Clinton C, HANSON, Robert L, KNOWLER, William C

“…Progression to Type 2 Diabetes Characterized by Moderate Then Rapid Glucose Increases Clinton C. Mason 1 2 , Robert L. Hanson 1 and William C. Knowler 1 1…”
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Associations of fatty acids in cerebrospinal fluid with peripheral glucose concentrations and energy metabolism by Jumpertz, Reiner, Guijarro, Ana, Pratley, Richard E, Mason, Clinton C, Piomelli, Daniele, Krakoff, Jonathan

“…Rodent experiments have emphasized a role of central fatty acid (FA) species, such as oleic acid, in regulating peripheral glucose and energy metabolism. Thus,…”
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Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program by Florez, Jose C, Jablonski, Kathleen A, McAteer, Jarred B, Franks, Paul W, Mason, Clinton C, Mather, Kieren, Horton, Edward, Goldberg, Ronald, Dabelea, Dana, Kahn, Steven E, Arakaki, Richard F, Shuldiner, Alan R, Knowler, William C

“…Common genetic variants have been recently associated with fasting glucose and insulin levels in white populations. Whether these associations replicate in…”
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A Prototype Exercise-Empowerment Mobile Video Game for Children With Cancer, and Its Usability Assessment: Developing Digital Empowerment Interventions for Pediatric Diseases by Bruggers, Carol S, Baranowski, Sabrina, Beseris, Mathew, Leonard, Rachel, Long, Derek, Schulte, Elizabeth, Shorter, Ashton, Stigner, Rowan, Mason, Clinton C, Bedrov, Alisa, Pascual, Ian, Bulaj, Grzegorz

“…Medical advances continue to improve morbidity and mortality of serious pediatric diseases, including cancer, driving research addressing diminished physical…”
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Bimodal distribution of RNA expression levels in human skeletal muscle tissue by Mason, Clinton C, Hanson, Robert L, Ossowski, Vicky, Bian, Li, Baier, Leslie J, Krakoff, Jonathan, Bogardus, Clifton

“…Many human diseases and phenotypes are related to RNA expression, levels of which are influenced by a wide spectrum of genetic and exposure-related factors. In…”
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Four study design principles for genetic investigations using next generation sequencing by Mason, Clinton C

“…Proper study design is crucial for obtaining meaningful results and reaching correct conclusions in scientific investigations. How to apply key study design…”
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Uncertainty quantification in breast cancer risk prediction models using self-reported family health history by Pflieger, Lance T, Mason, Clinton C, Facelli, Julio C

“…Family health history (FHx) is an important factor in breast and ovarian cancer risk assessment. As such, multiple risk prediction models rely strongly on FHx…”
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Change in the Distribution of Albuminuria According to Estimated Glomerular Filtration Rate in Pima Indians With Type 2 Diabetes by Pavkov, Meda E, Mason, Clinton C, Bennett, Peter H, Curtis, Jeffrey M, Knowler, William C, Nelson, Robert G

“…OBJECTIVE: We examined secular trends in the frequency distribution of albuminuria and estimated glomerular filtration rate (eGFR) in subjects with type 2…”
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Modeling the glucose–insulin regulatory system and ultradian insulin secretory oscillations with two explicit time delays by Li, Jiaxu, Kuang, Yang, Mason, Clinton C.

“…In the glucose–insulin regulatory system, ultradian insulin secretory oscillations are observed to have a period of 50–150min. After pioneering work traced…”
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Podocyte detachment and reduced glomerular capillary endothelial fenestration promote kidney disease in type 2 diabetic nephropathy by Weil, E Jennifer, Lemley, Kevin V, Mason, Clinton C, Yee, Berne, Jones, Lois I, Blouch, Kristina, Lovato, Tracy, Richardson, Meghan, Myers, Bryan D, Nelson, Robert G

“…Podocyte detachment and reduced endothelial cell fenestration and relationships between these features and the classic structural changes of diabetic…”
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Growth Factor Independence 1B-Mediated Transcriptional Repression and Lineage Allocation Require Lysine-Specific Demethylase 1-Dependent Recruitment of the BHC Complex by McClellan, David, Casey, Mattie J., Bareyan, Diana, Lucente, Helena, Ours, Christopher, Velinder, Matthew, Singer, Jason, Lone, Mehraju Din, Sun, Wenxiang, Coria, Yunuen, Mason, Clinton C., Engel, Michael E.

“…Growth factor independence 1B (GFI1B) coordinates assembly of transcriptional repressor complexes comprised of corepressors and histone-modifying enzymes to…”
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The clear cell sarcoma functional genomic landscape by Panza, Emanuele, Ozenberger, Benjamin B, Straessler, Krystal M, Barrott, Jared J, Li, Li, Wang, Yanliang, Xie, Mingchao, Boulet, Anne, Titen, Simon Wa, Mason, Clinton C, Lazar, Alexander J, Ding, Li, Capecchi, Mario R, Jones, Kevin B

“…Clear cell sarcoma (CCS) is a deadly malignancy affecting adolescents and young adults. It is characterized by reciprocal translocations resulting in…”
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Interoperable genetic lab test reports: mapping key data elements to HL7 FHIR specifications and professional reporting guidelines by Khalifa, Aly, Mason, Clinton C, Garvin, Jennifer Hornung, Williams, Marc S, Del Fiol, Guilherme, Jackson, Brian R, Bleyl, Steven B, Alterovitz, Gil, Huff, Stanley M

“…Abstract Objective In many cases, genetic testing labs provide their test reports as portable document format files or scanned images, which limits the…”
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Large-Scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers by Feusier, Julie E, Arunachalam, Sasi, Tashi, Tsewang, Baker, Monika J, VanSant-Webb, Chad, Ferdig, Amber, Welm, Bryan E, Rodriguez-Flores, Juan L, Ours, Christopher, Jorde, Lynn B, Prchal, Josef T, Mason, Clinton C

“…Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by detectable hematopoietic-associated gene mutations in a person without evidence of…”
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Burkitt lymphoma after solid‐organ transplant: Treatment and outcomes in the paediatric PTLD collaborative by Afify, Zeinab, Orjuela‐Grimm, Manuela, Smith, Christine Moore, Dalal, Mansi, Ford, James B., Pillai, Pallavi, Robles, Joanna M., Reddy, Sonika, McCormack, Sarah, Ehrhardt, Matthew J., Ureda, Tonya, Alperstein, Warren, Edington, Holly, Miller, Tamara P., Rubinstein, Jeremy D., Kavanaugh, Madison, Bukowinski, Andrew J., Friehling, Erika, Rivers, Julie M., Chisholm, Karen M., Marks, Lianna J., Mason, Clinton C.

“…Summary Burkitt lymphoma arising in paediatric post‐solid‐organ transplantation‐Burkitt lymphoma (PSOT‐BL) is a clinically aggressive malignancy and a rare…”
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SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA by Yan, Dongqing, Franzini, Anca, Pomicter, Anthony D, Halverson, Brayden J, Antelope, Orlando, Mason, Clinton C, Ahmann, Jonathan M, Senina, Anna V, Vellore, Nadeem A, Jones, Courtney L, Zabriskie, Matthew S, Than, Hein, Xiao, Michael J, van Scoyk, Alexandria, Patel, Ami B, Clair, Phillip M, Heaton, William L, Owen, Shawn C, Andersen, Joshua L, Egbert, Christina M, Reisz, Julie A, D'Alessandro, Angelo, Cox, James E, Gantz, Kevin C, Redwine, Hannah M, Iyer, Siddharth M, Khorashad, Jamshid S, Rajabi, Nima, Olsen, Christian A, O'Hare, Thomas, Deininger, Michael W

“…We discovered that the survival and growth of many primary acute myeloid leukemia (AML) samples and cell lines, but not normal CD34+ cells, are dependent on…”
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Identification of genetic targets in acute myeloid leukaemia for designing targeted therapy by Mason, Clinton C., Fiol, Carme R., Baker, Monika J., Nadal‐Melsio, Elisabet, Yebra‐Fernandez, Eva, Bicalho, Luciana, Chowdhury, Avirup, Albert, Michael, Reid, Alistair G., Claudiani, Simone, Apperley, Jane F., Khorashad, Jamshid S.

“…Summary Few effective therapies exist for acute myeloid leukaemia (AML), in part due to the molecular heterogeneity of this disease. We sought to identify…”
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