Search Results - "Maslov, Mikhail Y."

Vascular Dilation, Tachycardia, and Increased Inotropy Occur Sequentially with Increasing Epinephrine Dose Rate, Plasma and Myocardial Concentrations, and cAMP by Maslov, Mikhail Y., MD, PhD, Wei, Abraham E., BA, Pezone, Matthew J., BA, Edelman, Elazer R., MD, PhD, Lovich, Mark A., MD, PhD

“…Background While epinephrine infusion is widely used in critical care for inotropic support, there is no direct method to detect the onset and measure the…”
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Synergy between sacubitril and valsartan leads to hemodynamic, antifibrotic, and exercise tolerance benefits in rats with preexisting heart failure by Maslov, Mikhail Y, Foianini, Stephan, Mayer, Dita, Orlov, Michael V, Lovich, Mark A

“…Simultaneous neprilysin inhibition (NEPi) and angiotensin receptor blockade (ARB) with sacubitril/valsartan improves cardiac function and exercise tolerance in…”
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Interaction Between Sacubitril and Valsartan in Preventing Heart Failure Induced by Aortic Valve Insufficiency in Rats by Maslov, Mikhail Y., Foianini, Stephan, Mayer, Dita, Orlov, Michael V., Lovich, Mark A.

“…Synergistic interactions between neprilysin inhibition (NEPi) with sacubitril and angiotensin receptor type1 blockade (ARB) with valsartan have been implicated…”
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A Novel Paradigm for Sacubitril/Valsartan: Beta-Endorphin Elevation as a Contributor to Exercise Tolerance Improvement in Rats With Preexisting Heart Failure Induced by Pressure Overload by Maslov, Mikhail Y., Foianini, Stephan, Orlov, Michael V., Januzzi, James L., Lovich, Mark A.

“…Simultaneous angiotensin receptor (AT1) blockade and neprilysin inhibition with the use of sacubitril/valsartan has been recently approved to treat patients…”
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Infusion System Carrier Flow Perturbations and Dead-Volume: Large Effects on Drug Delivery In Vitro and Hemodynamic Responses in a Swine Model by Lovich, Mark A., Pezone, Matthew J., Maslov, Mikhail Y., Murray, Michael R., Wakim, Matthew G., Peterfreund, Robert A.

“…BACKGROUND:We have previously shown that, at constant carrier flow, drug infusion systems with large dead-volumes (V) slow the time to steady-state drug…”
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Drug Infusion System Manifold Dead-Volume Impacts the Delivery Response Time to Changes in Infused Medication Doses In Vitro and Also In Vivo in Anesthetized Swine by Lovich, Mark A., Wakim, Matthew G., Wei, Abraham, Parker, Michael J., Maslov, Mikhail Y., Pezone, Matthew J., Tsukada, Hisashi, Peterfreund, Robert A.

“…IV infusion systems can be configured with manifolds connecting multiple drug infusion lines to transcutaneous catheters. Prior in vitro studies suggest that…”
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Infusion System Architecture Impacts the Ability of Intensive Care Nurses to Maintain Hemodynamic Stability in a Living Swine Simulator by Pezone, Matthew J, Peterfreund, Robert A, Maslov, Mikhail Y, Govindaswamy, Radhika R, Lovich, Mark A

“…BACKGROUND:The authors have previously shown that drug infusion systems with large common volumes exhibit long delays in reaching steady-state drug delivery…”
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Computer Control of Drug Delivery by Continuous Intravenous Infusion: Bridging the Gap between Intended and Actual Drug Delivery by Parker, Michael J, Lovich, Mark A, Tsao, Amy C, Wei, Abraham E, Wakim, Matthew G, Maslov, Mikhail Y, Tsukada, Hisashi, Peterfreund, Robert A

“…BACKGROUND:Intravenous drug infusion driven by syringe pumps may lead to substantial temporal lags in achieving steady-state delivery at target levels when…”
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High concentrations of drug in target tissues following local controlled release are utilized for both drug distribution and biologic effect: An example with epicardial inotropic drug delivery by Maslov, Mikhail Y., Edelman, Elazer R., Wei, Abraham E., Pezone, Matthew J., Lovich, Mark A.

“…Local drug delivery preferentially loads target tissues with a concentration gradient from the surface or point of release that tapers down to more distant…”
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Myocardial drug distribution generated from local epicardial application: Potential impact of cardiac capillary perfusion in a swine model using epinephrine by Maslov, Mikhail Y., Edelman, Elazer R., Pezone, Matthew J., Wei, Abraham E., Wakim, Matthew G., Murray, Michael R., Tsukada, Hisashi, Gerogiannis, Iraklis S., Groothuis, Adam, Lovich, Mark A.

“…Prior studies in small mammals have shown that local epicardial application of inotropic compounds drives myocardial contractility without systemic side…”
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Hemorheological effects of secoisolariciresinol in ovariectomized rats by Maslov, Mikhail Y, Plotnikova, Tatiana M, Anishchenko, Anna M, Aliev, Oleg I, Nifantiev, Nikolay E, Plotnikov, Mark B

“…Postmenopausal women often develop hemorheological disorders which may affect the systemic blood circulation and present a cardiovascular risk factor. We…”
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Generation of purified nitric oxide from liquid N2O4 for the treatment of pulmonary hypertension in hypoxemic swine by Lovich, Mark A., Fine, David H., Denton, Ryan J., Wakim, Matt G., Wei, Abraham E., Maslov, Mikhail Y., Gamero, Lucas G., Vasquez, Gregory B., Johnson, Bryan J., Roscigno, Robert F., Gilbert, Richard J.

“…•Ambulatory systems for delivering NO have been limited by the size of storage tanks.•We present a novel method for generating inhaled NO from liquid N2O4.•The…”
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Inhaled Nitric Oxide Augments Left Ventricular Assist Device Capacity by Ameliorating Secondary Right Ventricular Failure by Lovich, Mark A, Pezone, Matthew J, Wakim, Matthew G, Denton, Ryan J, Maslov, Mikhail Y, Murray, Michael R, Tsukada, Hisashi, Agnihotri, Arvind K, Roscigno, Robert F, Gamero, Lucas G, Gilbert, Richard J

“…Clinical right ventricular (RV) impairment can occur with left ventricular assist device (LVAD) use, thereby compromising the therapeutic effectiveness. The…”
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Local epicardial inotropic drug delivery allows targeted pharmacologic intervention with preservation of myocardial loading conditions by Lovich, Mark A, Wei, Abraham E, Maslov, Mikhail Y, Wu, Peter I, Edelman, Elazer R

“…Local myocardial application of inotropes may allow the study of pharmacologically augmented central myocardial contraction in the absence of confounding…”
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Use of Pressure-volume Conductance Catheters in Real-time Cardiovascular Experimentation by Wei, Abraham E, Maslov, Mikhail Y, Pezone, Matthew J, Edelman, Elazer R, Lovich, Mark A

“…Background Most applications of pressure-volume conductance catheter measurements assess cardiovascular function at a single point in time after genetic,…”
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Hemorheological parameters and their correlations in OXYS rats: a new model of hyperviscosity syndrome by Maslov, Mikhail Y, Chernysheva, Galina A, Smol'jakova, Vera I, Aliev, Oleg I, Kolosova, Natalia G, Plotnikov, Mark B

“…Rheohaemapheresis aims to normalize major rheological parameters and is used to treat patients with dry age-related macular degeneration (AMD). While…”
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NITRIC OXIDE TREATMENT OF RV FAILURE ASSOCIATED WITH THE USE OF A LEFT VENTRICULAR ASSIST DEVICE AND HYPOXEMIA-INDUCED PULMONARY HYPERTENSION by Lovich, Mark A, Wakim, Mathew G, Maslov, Mikhail Y, Murray, Michael R, Pezone, Mathew J, Tsukada, Hisashi, Agnihotri, Arvind K, Denton, Ryan J, Gamero, Lucas G, Vasquez, Gregory B, Johnson, Bryan J, Roscigno, Robert F, Richard, Gilbert J

“…Inhaled NO decreased pulmonary vascular resistance (PVR, 7.0 ± 0.3 vs. 4.1 ± 0.4 WU, P = 0.0001) and increased the critical achievable pump speed prior to the…”
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Computer Control of Drug Delivery by Continuous Intravenous Infusion by Parker, Michael J., Lovich, Mark A., Tsao, Amy C., Wei, Abraham E., Wakim, Matthew G., Maslov, Mikhail Y., Tsukada, Hisashi, Peterfreund, Robert A.

“…Abstract Background: Intravenous drug infusion driven by syringe pumps may lead to substantial temporal lags in achieving steady-state delivery at target…”
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Abstract 9779: Nitric Oxide Generated Through Ascorbic Acid Reduction of Nitrogen Dioxide Reduces Pulmonary Vascular Resistance in Hypoxemic Swine with Minimal Inhaled and Exhaled Nitrogen Dioxide by Lovich, Mark A, Bruno, Natalie K, Wei, Abraham E, Maslov, Mikhail Y, Denton, Ryan J, Gamero, Lucas G, Vasquez, Gregory B, Gilbert, Richard J

“…Abstract only Background: Inhaled nitric oxide (NO) has the capacity to selectively dilate pulmonary blood vessels and improve oxygenation in patients with…”
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Abstract 15660: Sacubitril/Valsartan Mitigates “Aldosterone Breakthrough” in Rats With Arterial Hypertension While Valsartan and Enalapril Do Not by Maslov, Mikhail Y, Foianini, Stephan, Orlov, Michael V, Lovich, Mark A

“…IntroductionAngiotensin receptor neprilysin inhibition (ARNI) with sacubitril/valsartan effectively manages arterial hypertension. While inhibition of renin…”
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