Search Results - "Maslon, M M"

The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers by Hrstka, R, Nenutil, R, Fourtouna, A, Maslon, M M, Naughton, C, Langdon, S, Murray, E, Larionov, A, Petrakova, K, Muller, P, Dixon, M J, Hupp, T R, Vojtesek, B

“…Transcriptomic screens in breast cancer cell lines have identified a protein named anterior gradient-2 (AGR2) as a potentially novel oncogene overexpressed in…”
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A slow transcription rate causes embryonic lethality and perturbs kinetic coupling of neuronal genes by Maslon, Magdalena M, Braunschweig, Ulrich, Aitken, Stuart, Mann, Abigail R, Kilanowski, Fiona, Hunter, Chris J, Blencowe, Benjamin J, Kornblihtt, Alberto R, Adams, Ian R, Cáceres, Javier F

“…The rate of RNA polymerase II (RNAPII) elongation has an important role in the control of alternative splicing (AS); however, the in vivo consequences of an…”
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Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function by Haward, Fiona, Maslon, Magdalena M, Yeyati, Patricia L, Bellora, Nicolas, Hansen, Jan N, Aitken, Stuart, Lawson, Jennifer, von Kriegsheim, Alex, Wachten, Dagmar, Mill, Pleasantine, Adams, Ian R, Caceres, Javier F

“…Shuttling RNA-binding proteins coordinate nuclear and cytoplasmic steps of gene expression. The SR family proteins regulate RNA splicing in the nucleus and a…”
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The translational landscape of the splicing factor SRSF1 and its role in mitosis by Maslon, Magdalena M, Heras, Sara R, Bellora, Nicolas, Eyras, Eduardo, Cáceres, Javier F

“…The shuttling Serine/Arginine rich (SR) protein SRSF1 (previously known as SF2/ASF) is a splicing regulator that also activates translation in the cytoplasm…”
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p53 mRNA controls p53 activity by managing Mdm2 functions by Bourougaa, Karima, Malbert-Colas, Laurence, Maslon, Magda M, Powell, Darren J, Fåhraeus, Robin, Candeias, Marco M, Daskalogianni, Chrysoula, Naski, Nadia, Calvo, Fabien

“…The E3 ubiquitin ligase Mdm2 is a focal regulator of p53 tumour suppressor activity. It binds p53, promoting its polyubiquitination and degradation, and also…”
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Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum by Longman, Dasa, Jackson-Jones, Kathryn A, Maslon, Magdalena M, Murphy, Laura C, Young, Robert S, Stoddart, Jack J, Hug, Nele, Taylor, Martin S, Papadopoulos, Dimitrios K, Cáceres, Javier F

“…Nonsense-mediated decay (NMD) is a translation-dependent RNA quality control mechanism that occurs in the cytoplasm. However, it is unknown how NMD regulates…”
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Drug discovery and mutant p53 by Maslon, Magda M, Hupp, Ted R

“…Missense mutations in the p53 gene are commonly selected for in developing human cancer cells. These diverse mutations in p53 can inactivate its normal…”
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Histone H1 regulates non-coding RNA turnover on chromatin in a m6A-dependent manner by Fernández-Justel, José Miguel, Santa-María, Cristina, Martín-Vírgala, Sara, Ramesh, Shreya, Ferrera-Lagoa, Alberto, Salinas-Pena, Mónica, Isoler-Alcaraz, Javier, Maslon, Magdalena M., Jordan, Albert, Cáceres, Javier F., Gómez, María

“…Linker histones are highly abundant chromatin-associated proteins with well-established structural roles in chromatin and as general transcriptional…”
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A Divergent Substrate-Binding Loop within the Pro-oncogenic Protein Anterior Gradient-2 Forms a Docking Site for Reptin by Maslon, Magdalena M., Hrstka, Roman, Vojtesek, Borek, Hupp, Ted R.

“…Anterior gradient-2 (AGR2) functions in a range of biological systems, including goblet cell formation, limb regeneration, inhibition of p53, and metastasis…”
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Slow RNAPII Transcription Elongation Rate, Low Levels of RNAPII Pausing, and Elevated Histone H1 Content at Promoters Associate with Higher m6A Deposition on Nascent mRNAs by Gallego, Alicia, Fernández-Justel, José Miguel, Martín-Vírgala, Sara, Maslon, Magdalena M, Gómez, María

“…N6-methyladenosine modification (m6A) fine-tunes RNA fate in a variety of ways, thus regulating multiple fundamental biological processes. m6A writers bind to…”
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Anterior Gradient-3: A novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models by Gray, Terry A., MacLaine, Nicola J., Michie, Caroline O., Bouchalova, Pavla, Murray, Euan, Howie, Jacqueline, Hrstka, Roman, Maslon, Magdalena M., Nenutil, Rudolf, Vojtesek, Borek, Langdon, Simon, Hayward, Larry, Gourley, Charlie, Hupp, Ted R.

“…The Anterior Gradient (AGR) genes AGR2 and AGR3 are part of the Protein Disulfide Isomerase (PDI) family and harbour core thioredoxin folds (CxxS motifs) that…”
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Discovery of a novel ligand that modulates the protein-protein interactions of the AAA+ superfamily oncoprotein reptin by Healy, Alan R, Houston, Douglas R, Remnant, Lucy, Huart, Anne-Sophie, Brychtova, Veronika, Maslon, Magda M, Meers, Olivia, Muller, Petr, Krejci, Adam, Blackburn, Elizabeth A, Vojtesek, Borek, Hernychova, Lenka, Walkinshaw, Malcolm D, Westwood, Nicholas J, Hupp, Ted R

“…Developing approaches to discover protein-protein interactions (PPIs) remains a fundamental challenge. A chemical biology platform is applied here to identify…”
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In memoriam; Leon F. Schiff, 1885-1957 by MASLON, M

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Discovery of a novel ligand that modulates the protein-protein interactions of the AAA+ superfamily oncoprotein reptinElectronic supplementary information (ESI) available. See DOI: 10.1039/c4sc03885a by Healy, Alan R, Houston, Douglas R, Remnant, Lucy, Huart, Anne-Sophie, Brychtova, Veronika, Maslon, Magda M, Meers, Olivia, Muller, Petr, Krejci, Adam, Blackburn, Elizabeth A, Vojtesek, Borek, Hernychova, Lenka, Walkinshaw, Malcolm D, Westwood, Nicholas J, Hupp, Ted R

“…Developing approaches to discover protein-protein interactions (PPIs) remains a fundamental challenge. A chemical biology platform is applied here to identify…”
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Discovery of a novel ligand that modulates the protein–protein interactions of the AAA+ superfamily oncoprotein reptin† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc03885a Click here for additional data file by Healy, Alan R., Houston, Douglas R., Remnant, Lucy, Huart, Anne-Sophie, Brychtova, Veronika, Maslon, Magda M., Meers, Olivia, Muller, Petr, Krejci, Adam, Blackburn, Elizabeth A., Vojtesek, Borek, Hernychova, Lenka, Walkinshaw, Malcolm D., Westwood, Nicholas J., Hupp, Ted R.

“…Discovery and use of a chemical tool. Developing approaches to discover protein–protein interactions (PPIs) remains a fundamental challenge. A chemical biology…”
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Evaluation of tubeless gastric analysis; report of 90 determinations by intubation and tubeless methods made simultaneously by BECKER, F P, MASLON, M

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Gastroduodenal ulcer following cortisone therapy; report of a case with fatal hemorrhage by BULOVA, P N, BECKER, F P, MASLON, M

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