Search Results - "Maslen, Sarah L."

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN by Stingele, Julian, Bellelli, Roberto, Alte, Ferdinand, Hewitt, Graeme, Sarek, Grzegorz, Maslen, Sarah L., Tsutakawa, Susan E., Borg, Annabel, Kjær, Svend, Tainer, John A., Skehel, J. Mark, Groll, Michael, Boulton, Simon J.

“…Covalent DNA-protein crosslinks (DPCs) are toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription…”
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Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation by Cattin-Ortolá, Jérôme, Welch, Lawrence G., Maslen, Sarah L., Papa, Guido, James, Leo C., Munro, Sean

“…The Spike (S) protein of SARS-CoV-2 binds ACE2 to direct fusion with host cells. S comprises a large external domain, a transmembrane domain, and a short…”
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PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination by Clarke, Thomas L., Sanchez-Bailon, Maria Pilar, Chiang, Kelly, Reynolds, John J., Herrero-Ruiz, Joaquin, Bandeiras, Tiago M., Matias, Pedro M., Maslen, Sarah L., Skehel, J. Mark, Stewart, Grant S., Davies, Clare C.

“…Protein post-translation modification plays an important role in regulating DNA repair; however, the role of arginine methylation in this process is poorly…”
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Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne by Mevissen, Tycho E. T., Kulathu, Yogesh, Mulder, Monique P.C., Geurink, Paul P., Maslen, Sarah L., Gersch, Malte, Elliott, Paul R., Burke, John E., van Tol, Bianca D. M., Akutsu, Masato, El Oualid, Farid, Kawasaki, Masato, Freund, Stefan M.V., Ovaa, Huib, Komander, David

“…The structures of the deubiquitinating enzyme Cezanne alone or in complex with its substrate or product are solved, showing how Cezanne specifically targets…”
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Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes by Tremel, Shirley, Ohashi, Yohei, Morado, Dustin R., Bertram, Jessie, Perisic, Olga, Brandt, Laura T. L., von Wrisberg, Marie-Kristin, Chen, Zhuo A., Maslen, Sarah L., Kovtun, Oleksiy, Skehel, Mark, Rappsilber, Juri, Lang, Kathrin, Munro, Sean, Briggs, John A. G., Williams, Roger L.

“…The lipid phosphatidylinositol-3-phosphate (PI3P) is a regulator of two fundamental but distinct cellular processes, endocytosis and autophagy, so its…”
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A bipartite structural organization defines the SERINC family of HIV-1 restriction factors by Pye, Valerie E., Rosa, Annachiara, Bertelli, Cinzia, Struwe, Weston B., Maslen, Sarah L., Corey, Robin, Liko, Idlir, Hassall, Mark, Mattiuzzo, Giada, Ballandras-Colas, Allison, Nans, Andrea, Takeuchi, Yasuhiro, Stansfeld, Phillip J., Skehel, J. Mark, Robinson, Carol V., Pizzato, Massimo, Cherepanov, Peter

“…The human integral membrane protein SERINC5 potently restricts HIV-1 infectivity and sensitizes the virus to antibody-mediated neutralization. Here, using…”
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Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates by Kiss, Leo, Rhinesmith, Tyler, Luptak, Jakub, Dickson, Claire F., Weidenhausen, Jonas, Smyly, Shannon, Yang, Ji-Chun, Maslen, Sarah L., Sinning, Irmgard, Neuhaus, David, Clift, Dean, James, Leo C.

“…TRIM proteins are the largest family of E3 ligases in mammals. They include the intracellular antibody receptor TRIM21, which is responsible for mediating…”
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Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly by Fischer, Elyse S., Yu, Conny W. H., Hevler, Johannes F., McLaughlin, Stephen H., Maslen, Sarah L., Heck, Albert J. R., Freund, Stefan M. V., Barford, David

“…In response to improper kinetochore-microtubule attachments in mitosis, the spindle assembly checkpoint (SAC) assembles the mitotic checkpoint complex (MCC) to…”
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Identification of photocrosslinking peptide ligands by mRNA display by Wu, Yuteng, Bertran, M. Teresa, Joshi, Dhira, Maslen, Sarah L., Hurd, Catherine, Walport, Louise J.

“…Photoaffinity labelling is a promising method for studying protein-ligand interactions. However, obtaining a specific, efficient crosslinker can require…”
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Synthesis of Azadirachtin: A Long but Successful Journey by Veitch, Gemma E, Beckmann, Edith, Burke, Brenda J, Boyer, Alistair, Maslen, Sarah L, Ley, Steven V

“…22 Years in the making: Azadirachtin (1) was synthesized for the first time by a highly convergent approach, utilizing a Claisen rearrangement and a radical…”
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High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center by Baños-Mateos, Soledad, van Roon, Anne-Marie M., Lang, Ulla F., Maslen, Sarah L., Skehel, J. Mark, Lamers, Meindert H.

“…High-fidelity DNA replication depends on a proofreading 3′–5′ exonuclease that is associated with the replicative DNA polymerase. The replicative DNA…”
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FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex by Collis, Spencer J., Ciccia, Alberto, Deans, Andrew J., Hořejší, Zuzana, Martin, Julie S., Maslen, Sarah L., Skehel, J. Mark, Elledge, Stephen J., West, Stephen C., Boulton, Simon J.

“…The Fanconi anemia (FA) pathway is implicated in DNA repair and cancer predisposition. Central to this pathway is the FA core complex, which is targeted to…”
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Mechanism of parkin activation by PINK1 by Gladkova, Christina, Maslen, Sarah L., Skehel, J. Mark, Komander, David

“…Mutations in the E3 ubiquitin ligase parkin (PARK2, also known as PRKN) and the protein kinase PINK1 (also known as PARK6) are linked to autosomal-recessive…”
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Retention of the Native Epigenome in Purified Mammalian Chromatin by Ehrensberger, Andreas H, Franchini, Don-Marc, East, Philip, George, Roger, Matthews, Nik, Maslen, Sarah L, Svejstrup, Jesper Q

“…A protocol is presented for the isolation of native mammalian chromatin as fibers of 25-250 nucleosomes under conditions that preserve the natural epigenetic…”
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Protein Complexes of the Escherichia coli Cell Envelope by Stenberg, Filippa, Chovanec, Peter, Maslen, Sarah L., Robinson, Carol V., Ilag, Leopold L., von Heijne, Gunnar, Daley, Daniel O.

“…Protein complexes are an intrinsic aspect of life in the membrane. Knowing which proteins are assembled in these complexes is therefore essential to…”
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Structure elucidation of arabinoxylan isomers by normal phase HPLC–MALDI-TOF/TOF-MS/MS by Maslen, Sarah L., Goubet, Florence, Adam, Alex, Dupree, Paul, Stephens, Elaine

“…Normal phase-high performance liquid chromatography (NP-HPLC) coupled to matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight…”
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Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2A That Is Essential for Mitosis by Mochida, Satoru, Maslen, Sarah L, Skehel, Mark, Hunt, Tim

“…Entry into mitosis in eukaryotes requires the activity of cyclin-dependent kinase 1 (Cdk1). Cdk1 is opposed by protein phosphatases in two ways: They inhibit…”
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Correction: Retention of the Native Epigenome in Purified Mammalian Chromatin by Ehrensberger, Andreas H, Franchini, Don-Marc, East, Philip, George, Roger, Matthews, Nik, Maslen, Sarah L, Svejstrup, Jesper Q

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Oligosaccharide relative quantitation using isotope tagging and normal-phase liquid chromatography/mass spectrometry by Ridlova, Gabriela, Mortimer, Jenny C., Maslen, Sarah L., Dupree, Paul, Stephens, Elaine

“…The growing interest in the conversion of plant biomass into biofuels has recently highlighted the lack of analytical techniques that are able to profile the…”
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Structure of PINK1 in complex with its substrate ubiquitin by Schubert, Alexander F., Gladkova, Christina, Pardon, Els, Wagstaff, Jane L., Freund, Stefan M. V., Steyaert, Jan, Maslen, Sarah L., Komander, David

“…Autosomal-recessive juvenile Parkinsonism (AR-JP) is caused by mutations in a number of PARK genes, in particular the genes encoding the E3 ubiquitin ligase…”
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