Search Results - "Masikat, Mary Rose"

Production of antibodies and antibody fragments containing non-natural amino acids in Escherichia coli by Blake-Hedges, Jacquelyn, Groff, Dan, Foo, Wilson, Hanson, Jeffrey, Castillo, Elenor, Wen, Miao, Cheung, Diana, Masikat, Mary Rose, Lu, Jian, Park, Young, Carlos, Nina Abi, Usman, Hans, Fong, Kevin, Yu, Abigail, Zhou, Sihong, Kwong, Joyce, Tran, Cuong, Li, Xiaofan, Yuan, Dawei, Hallam, Trevor, Yin, Gang

“…Therapeutic bioconjugates are emerging as an essential tool to combat human disease. Site-specific conjugation technologies are widely recognized as the…”
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RF1 attenuation enables efficient non-natural amino acid incorporation for production of homogeneous antibody drug conjugates by Yin, Gang, Stephenson, Heather T., Yang, Junhao, Li, Xiaofan, Armstrong, Stephanie M., Heibeck, Tyler H., Tran, Cuong, Masikat, Mary Rose, Zhou, Sihong, Stafford, Ryan L., Yam, Alice Y., Lee, John, Steiner, Alexander R., Gill, Avinash, Penta, Kalyani, Pollitt, Sonia, Baliga, Ramesh, Murray, Christopher J., Thanos, Christopher D., McEvoy, Leslie M., Sato, Aaron K., Hallam, Trevor J.

“…Amber codon suppression for the insertion of non-natural amino acids (nnAAs) is limited by competition with release factor 1 (RF1). Here we describe the genome…”
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RP-HPLC DAR Characterization of Site-Specific Antibody Drug Conjugates Produced in a Cell-Free Expression System by Xu, Yiren, Jiang, Guifeng, Tran, Cuong, Li, Xiaofan, Heibeck, Tyler H., Masikat, Mary Rose, Cai, Qi, Steiner, Alexander R., Sato, Aaron K., Hallam, Trevor J., Yin, Gang

“…Antibody drug conjugates (ADCs) harness the target specificity of a monoclonal antibody (mAb) and the high cytotoxicity of a small molecule, enabling improved…”
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An Integrated In Vivo/In Vitro Protein Production Platform for Site-Specific Antibody Drug Conjugates by Hanson, Jeffrey, Groff, Dan, Carlos, Abi, Usman, Hans, Fong, Kevin, Yu, Abigail, Armstrong, Stephanie, Dwyer, Allison, Masikat, Mary Rose, Yuan, Dawei, Tran, Cuong, Heibeck, Tyler, Zawada, James, Chen, Rishard, Hallam, Trevor, Yin, Gang

“…The XpressCF+ cell-free protein synthesis system is a robust platform for the production of non-natural amino acids containing antibodies, which enable the…”
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Functional Analysis of the Transmembrane Domain and Activation Cleavage of Human Corin by Knappe, Sabine, Wu, Faye, Masikat, Mary Rose, Morser, John, Wu, Qingyu

“…Corin is a cardiac transmembrane serine protease. In cell-based studies, corin converted pro-atrial natriuretic peptide (pro-ANP) to mature ANP, suggesting…”
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A simplified and robust protocol for immunoglobulin expression in Escherichia coli cell-free protein synthesis systems by Cai, Qi, Hanson, Jeffrey A., Steiner, Alexander R., Tran, Cuong, Masikat, Mary Rose, Chen, Rishard, Zawada, James F., Sato, Aaron K., Hallam, Trevor J., Yin, Gang

“…Cell‐free protein synthesis (CFPS) systems allow for robust protein expression with easy manipulation of conditions to improve protein yield and folding…”
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Abstract NT-090: PRECLINICAL ACTIVITY AND SAFETY OF STRO-002, A NOVEL ADC TARGETING FOLATE RECEPTOR ALPHA FOR OVARIAN AND ENDOMETRIAL CANCER by Abrahams, Cristina, Krimm, Stellanie, Li, Xiaofan, Zhou, Sihong, Hanson, Jeffrey, Masikat, Mary Rose, Bajjuri, Krishna, Heibeck, Tyler, Kothari, Dharti, Yu, Abigail, Henningsen, Robert, Tran, Cuong, Yin, Gang, Zawada, James, Hang, Julie, Bruhns, Maureen, Solis, Willy, Steiner, Alexander, Galan, Adam, Kline, Toni, Stafford, Ryan, Yam, Alice, Almeida, Venita I. De, Lupher, Mark, Hallam, Trevor

“…Abstract OBJECTIVES: Folate receptor alpha (FolRα) is a cell-surface glycoprotein, highly expressed in ovarian and endometrial adenocarcinoma, and thus a…”
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Abstract 1782: Discovery and activity of STRO-002, a novel ADC targeting folate receptor alpha for ovarian and endometrial cancer by Li, Xiaofan, Abrahams, Cristina, Zhou, Sihong, Krimm, Stellanie, Henningsen, Robert, Stephenson, Heather, Hanson, Jeffrey, Masikat, Mary Rose, Bajjuri, Krishna, Heibeck, Tyler, Tran, Cuong, Yin, Gang, Zawada, James, Sarma, Ganapathy, Chen, Joy, Bruhns, Maureen, Solis, Willy, Steiner, Alexander, Galan, Adam, Kline, Toni, Stafford, Ryan, Yam, Alice, Almeida, Venita I. De, Lupher, Mark, Hallam, Trevor

“…Abstract Folate receptor alpha (FolRα) is a glycosylphosphatidylinositol linked cell-surface glycoprotein that is widely expressed in serous and epithelial…”
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1359 Half-life extended engineered IL18 variants that escape the negative regulation of IL18BP by Li, Xiaofan, Abrahams, Cristina, Gakhal, Amandeep, Yang, Junhao, Brar, Kevin, Calarese, Daniel, Henningsen, Robert, Lee, Grace, Neighbors, Katie, Smith, Jennifer, McGeehan, Andrew, Embry, Millicent, Yu, Abigail, Nguyen, Alan, Bajjuri, Krishna, Miao Wen, Park, Young, Tran, Cuong, Mary Rose Masikat, Yin, Gang, Yam, Alice, Bedard, Kristin, Hallam, Trevor

“…BackgroundInterleukin-18 (IL18) is a proinflammatory cytokine secreted by monocytes and macrophages to promote T and NK cells activation. While wild type IL18…”
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A simplified and robust protocol for immunoglobulin expression in E scherichia coli cell‐free protein synthesis systems by Cai, Qi, Hanson, Jeffrey A., Steiner, Alexander R., Tran, Cuong, Masikat, Mary Rose, Chen, Rishard, Zawada, James F., Sato, Aaron K., Hallam, Trevor J., Yin, Gang

“…Cell‐free protein synthesis (CFPS) systems allow for robust protein expression with easy manipulation of conditions to improve protein yield and folding…”
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In vitro Fab display: a cell-free system for IgG discovery by Stafford, Ryan L., Matsumoto, Marissa L., Yin, Gang, Cai, Qi, Fung, Juan Jose, Stephenson, Heather, Gill, Avinash, You, Monica, Lin, Shwu-Hwa, Wang, Willie D., Masikat, Mary Rose, Li, Xiaofan, Penta, Kalyani, Steiner, Alex R., Baliga, Ramesh, Murray, Christopher J., Thanos, Christopher D., Hallam, Trevor J., Sato, Aaron K.

“…Selection technologies such as ribosome display enable the rapid discovery of novel antibody fragments entirely in vitro. It has been assumed that the open…”
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Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin by Knappe, Sabine, Wu, Faye, Masikat, Mary Rose, Morser, John, Wu, Qingyu

“…Corin is a cardiac transmembrane serine protease. In cell-based studies, corin converted pro-atrial natriuretic peptide (pro-ANP) to mature ANP, suggesting…”
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1073. Cell Tropism of JC-Virus Derived Viral-Like Particles In Vitro and In Vivo by Liu, Perry, Cashion, Linda, Qian, Hu Sheng, Ast, Oliver, Citkowicz, Andrzej, Harvey, Susan, Mitrovic, Branka, Rose Masikat, Mary, Larsen, Brent, Harkins, Richard N., Rubanyi, Gabor M., Petry, Harald

“…The goal of the present study was to explore the tropism of Virus-Like Particles (VLP) originating from the human polyoma JC- virus (JCV) in vitro and in vivo…”
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