Search Results - "Masick, Brian"

Discovery, Optimization, and Biological Evaluation of 5‑(2-(Trifluoromethyl)phenyl)­indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists by Rooney, Lisa, Vidal, Agnès, D’Souza, Anne-Marie, Devereux, Nick, Masick, Brian, Boissel, Valerie, West, Ryan, Head, Victoria, Stringer, Rowan, Lao, Jianmin, Petrus, Matt J, Patapoutian, Ardem, Nash, Mark, Stoakley, Natalie, Panesar, Moh, Verkuyl, J. Martin, Schumacher, Andrew M, Petrassi, H. Michael, Tully, David C

“…A high throughput screening campaign identified 5-(2-chlorophenyl)indazole compound 4 as an antagonist of the transient receptor potential A1 (TRPA1) ion…”
Get full text

Substrate optimization for monitoring cathepsin C activity in live cells by Li, Jun, Petrassi, H. Michael, Tumanut, Christine, Masick, Brian T., Trussell, Christopher, Harris, Jennifer L.

“…A series of peptidic fluorogenic substrates were synthesized to develop a flow cytometry assay (FACS) to monitor the proteolytic activity of cathepsin C in…”
Get full text

Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers by Tully, David C., Liu, Hong, Chatterjee, Arnab K., Alper, Phil B., Epple, Robert, Williams, Jennifer A., Roberts, Michael J., Woodmansee, David H., Masick, Brian T., Tumanut, Christine, Li, Jun, Spraggon, Glen, Hornsby, Michael, Chang, Jonathan, Tuntland, Tove, Hollenbeck, Thomas, Gordon, Perry, Harris, Jennifer L., Karanewsky, Donald S.

“…The synthesis and SAR a series of arylaminoethyl amide cathepsin S inhibitors are reported, focusing on the optimization of P3 and P2 subunits. An X-ray…”
Get full text

Substrate optimization for monitoring cathepsin C activity in live cells : Tetrahedron Young Investigator Award 2004 by JUN LI, PETRASSI, H. Michael, TUMANUT, Christine, MASICK, Brian T, TRUSSELL, Christopher, HARRIS, Jennifer L

Get full text

A strategy to profile prime and non-prime proteolytic substrate specificity by Petrassi, H. Michael, Williams, Jennifer A., Li, Jun, Tumanut, Christine, Ek, Jared, Nakai, Takashi, Masick, Brian, Backes, Bradley J., Harris, Jennifer L.

“…[Display omitted] A strategy was developed to determine the prime and non-prime substrate specificity of serine, threonine and cysteine proteases. ACC…”
Get full text