Search Results - "Masi, Alessandra"

Hsp90α regulates ATM and NBN functions in sensing and repair of DNA double‐strand breaks by Pennisi, Rosa, Antoccia, Antonio, Leone, Stefano, Ascenzi, Paolo, Masi, Alessandra

“…The molecular chaperone heat shock protein 90 (Hsp90α) regulates cell proteostasis and mitigates the harmful effects of endogenous and exogenous stressors on…”
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Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects by Di Bella, Stefano, Ascenzi, Paolo, Siarakas, Steven, Petrosillo, Nicola, di Masi, Alessandra

“…Clostridium difficile infection (CDI) has significant clinical impact especially on the elderly and/or immunocompromised patients. The pathogenicity of…”
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Human Serum Albumin: From Molecular Aspects to Biotechnological Applications by di Masi, Alessandra

“…Human serum albumin (HSA), the most abundant protein in plasma, is a monomeric multidomain macromolecule that represents the main determinant of plasma oncotic…”
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Serum Albumin: A Multifaced Enzyme by De Simone, Giovanna, di Masi, Alessandra, Ascenzi, Paolo

“…Human serum albumin (HSA) is the most abundant protein in plasma, contributing actively to oncotic pressure maintenance and fluid distribution between body…”
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H2S: A "Double face" molecule in health and disease by Masi, Alessandra di, Ascenzi, Paolo

“…H2S is a colorless, poisonous, and flammable gas with the characteristic foul odor of rotten eggs. H2S is present in effluent from hydrothermal vents and…”
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Neonicotinoid trapping by the FA1 site of human serum albumin by Leboffe, Loris, Masi, Alessandra, Trezza, Viviana, Pasquadibisceglie, Andrea, Macari, Gabriele, Polticelli, Fabio, Ascenzi, Paolo

“…Neonicotinoids are a widely used class of insecticides that target the acetylcholine recognition site of the nicotinic acetylcholine receptors in the central…”
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Quantitative protein sensing with germanium THz-antennas manufactured using CMOS processes by Hardt, Elena, Chavarin, Carlos Alvarado, Gruessing, Soenke, Flesch, Julia, Skibitzki, Oliver, Spirito, Davide, Vita, Gian Marco, Simone, Giovanna De, Masi, Alessandra di, You, Changjiang, Witzigmann, Bernd, Piehler, Jacob, Capellini, Giovanni

“…The development of a CMOS manufactured THz sensing platform could enable the integration of state-of-the-art sensing principles with the mixed signal…”
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Are DNA damage response kinases a target for the differentiation treatment of acute myeloid leukemia? by Pennisi, Rosa, Albanesi, Jacopo, Ascenzi, Paolo, Nervi, Clara, Masi, Alessandra

“…Acute myeloid leukemia (AML) is a genetically heterogeneous malignancy characterized by the expansion of hematopoietic stem/progenitor cells (HPCs) blocked at…”
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Quantifying pH-induced changes in plasma strong ion difference during experimental acidosis: clinical implications for base excess interpretation by Giosa, Lorenzo, Zadek, Francesco, Busana, Mattia, De Simone, Giovanna, Brusatori, Serena, Krbec, Martin, Duska, Frantisek, Brambilla, Paolo, Zanella, Alberto, Di Masi, Alessandra, Caironi, Pietro, Perez, Emanuele, Gattinoni, Luciano, Langer, Thomas

“…It is commonly assumed that changes in plasma strong ion difference (SID) result in equal changes in whole blood base excess (BE). However, at varying pH,…”
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Clinical Use of Raman Spectroscopy Improves Diagnostic Accuracy for Indeterminate Thyroid Nodules by Palermo, Andrea, Sodo, Armida, Naciu, Anda Mihaela, Di Gioacchino, Michael, Paolucci, Alessio, di Masi, Alessandra, Maggi, Daria, Crucitti, Pierfilippo, Longo, Filippo, Perrella, Eleonora, Taffon, Chiara, Verri, Martina, Ricci, Maria Antonietta, Crescenzi, Anna

“…Background and Objective: Molecular analysis of thyroid fine-needle aspiration (FNA) specimens is believed to improve the management of indeterminate nodules…”
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Thyroid cancer diagnosis by Raman spectroscopy by Sbroscia, Marco, Di Gioacchino, Michael, Ascenzi, Paolo, Crucitti, Pierfilippo, di Masi, Alessandra, Giovannoni, Isabella, Longo, Filippo, Mariotti, Davide, Naciu, Anda Mihaela, Palermo, Andrea, Taffon, Chiara, Verri, Martina, Sodo, Armida, Crescenzi, Anna, Ricci, Maria Antonietta

“…Over the last 50 years, the incidence of human thyroid cancer disease has seen a significative increment. This comes along with an even higher increment of…”
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Carbon monoxide: An unusual drug by Gullotta, Francesca, Masi, Alessandra di, Ascenzi, Paolo

“…The highly toxic gas carbon monoxide (CO) displays many physiological roles in several organs and tissues. Although many diseases, including cancer,…”
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Phosphodiesterase 2A inhibition corrects the aberrant behavioral traits observed in genetic and environmental preclinical models of Autism Spectrum Disorder by Schiavi, Sara, Carbone, Emilia, Melancia, Francesca, di Masi, Alessandra, Jarjat, Marielle, Brau, Fréderic, Cardarelli, Silvia, Giorgi, Mauro, Bardoni, Barbara, Trezza, Viviana

“…Pharmacological inhibition of phosphodiesterase 2A (PDE2A), which catalyzes the hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine…”
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Haptoglobin: From hemoglobin scavenging to human health by di Masi, Alessandra, De Simone, Giovanna, Ciaccio, Chiara, D'Orso, Silvia, Coletta, Massimo, Ascenzi, Paolo

“…Haptoglobin (Hp) belongs to the family of acute-phase plasma proteins and represents the most important plasma detoxifier of hemoglobin (Hb). The basic Hp…”
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NBN Gene Polymorphisms and Cancer Susceptibility: A Systemic Review by Berardinelli, Francesco, di Masi, Alessandra, Antoccia, Antonio

“…The relationship between DNA repair failure and cancer is well established as in the case of rare, high penetrant genes in high cancer risk families. Beside…”
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Retinoic acid receptors: From molecular mechanisms to cancer therapy by di Masi, Alessandra, Leboffe, Loris, De Marinis, Elisabetta, Pagano, Francesca, Cicconi, Laura, Rochette-Egly, Cécile, Lo-Coco, Francesco, Ascenzi, Paolo, Nervi, Clara

“…Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum of pleiotropic effects in cell growth and differentiation that…”
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Ligand binding to the FA3-FA4 cleft inhibits the esterase-like activity of human serum albumin by Ascenzi, Paolo, Leboffe, Loris, di Masi, Alessandra, Trezza, Viviana, Fanali, Gabriella, Gioia, Magda, Coletta, Massimo, Fasano, Mauro

“…The hydrolysis of 4-nitrophenyl esters of hexanoate (NphOHe) and decanoate (NphODe) by human serum albumin (HSA) at Tyr411, located at the FA3-FA4 site, has…”
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Neuroglobin: From structure to function in health and disease by Ascenzi, Paolo, di Masi, Alessandra, Leboffe, Loris, Fiocchetti, Marco, Nuzzo, Maria Teresa, Brunori, Maurizio, Marino, Maria

“…In 2000, the third member of the globin family was discovered in human and mouse brain and named neuroglobin (Ngb). Ngb is a monomeric 3/3 globin structurally…”
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Zebrafish (Danio rerio) as a Model System to Investigate the Role of the Innate Immune Response in Human Infectious Diseases by Franza, Maria, Varricchio, Romualdo, Alloisio, Giulia, De Simone, Giovanna, Di Bella, Stefano, Ascenzi, Paolo, di Masi, Alessandra

“…The zebrafish (Danio rerio) has emerged as a valuable model for studying host-pathogen interactions due to its unique combination of characteristics. These…”
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Drugs modulate allosterically heme-Fe-recognition by human serum albumin and heme-fe-mediated reactivity by di Masi, Alessandra, Leboffe, Loris, Trezza, Viviana, Fanali, Gabriella, Coletta, Massimo, Fasano, Mauro, Ascenzi, Paolo

“…Human serum albumin (HSA) represents an important determinant of plasma oncotic pressure and a relevant factor that modulates fluid distribution between the…”
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