An overview of liquid chromatographic methods for analyzing new generation anti-epileptic drugs

An overview of liquid chromatographic methods for analyzing new generation anti-epileptic drugs

Pregabalin, Lacosamide, Rufinamide, Perampanel, Eslicarbazepine acetate, Brivaracetam, Cannabidiol, Stiripentol, Everolimus, Cenobamate, and Fenfluramine are drugs of the third generation of antiepileptic drugs registered by International Coalition of Medicine Regulatory Authorities between 2000 and...

Full description

Saved in:
Bibliographic Details
Published in:Journal of liquid chromatography & related technologies Vol. 45; no. 5-8; pp. 66 - 83
Main Authors: ALSaeedy, Mohammed, Hasan, Ahmed, Al-Adhreai, Arwa, Alrabie, Ali, Qaba, Hafsah, Mashrah, Abdulrahman, Öncü-Kaya, Elif Mine
Format: Journal Article
Language:English
Published: Abingdon Taylor & Francis 09-05-2022
Taylor & Francis Ltd
Subjects:
Acetic acid
Additives
Anti-epileptic drugs
Antiepileptic agents
Drugs
Epilepsy
Fenfluramine
Liquid chromatography
Regulatory agencies
Sample preparation
separation
Stiripentol
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pregabalin, Lacosamide, Rufinamide, Perampanel, Eslicarbazepine acetate, Brivaracetam, Cannabidiol, Stiripentol, Everolimus, Cenobamate, and Fenfluramine are drugs of the third generation of antiepileptic drugs registered by International Coalition of Medicine Regulatory Authorities between 2000 and 2021. There are 213 peer-reviewed papers on antiepileptic drug analysis in the literature over the last three decades (1990-2022) which were reviewed in this article to provide an extensive overview of liquid chromatography techniques used to determine antiepileptic drugs. These details were discussed on the basis of a matrix: additives that are used to prepare a dosage form, sample preparation technique, column, limits of detection and quantification, types of elution in chromatography (isocratic or gradient), and detector. This review article will provide vital information to the scientific community in order to identify the most appropriate approach for antiepileptic drug analysis and determination.
ISSN:1082-6076
1520-572X
DOI:10.1080/10826076.2022.2134146