Search Results - "Maser, Tyler"

Nrf2-Dependent and -Independent Effects of tert -Butylhydroquinone, CDDO-Im, and H 2 O 2 in Human Jurkat T Cells as Determined by CRISPR/Cas9 Gene Editing by Zagorski, Joseph W, Maser, Tyler P, Liby, Karen T, Rockwell, Cheryl E

“…Nuclear factor erythroid 2-related factor 2 (Nrf2) is a stress-activated transcription factor activated by stimuli such as electrophilic compounds and other…”
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The MDM2 inhibitor CGM097 combined with the BET inhibitor OTX015 induces cell death and inhibits tumor growth in models of neuroblastoma by Maser, Tyler, Zagorski, Joseph, Kelly, Shannon, Ostrander, Anna, Goodyke, Austin, Nagulapally, Abhinav, Bond, Jeffrey, Park, Yeonhee, Saulnier Sholler, Giselle

“…Background Neuroblastoma (NB) is the most common extracranial solid tumor in infants and children, with amplification of the oncogene MYCN being a hallmark of…”
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Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblastoma by Maser, Tyler, Rich, Maria, Hayes, David, Zhao, Ping, Nagulapally, Abhinav B., Bond, Jeffrey, Saulnier Sholler, Giselle

“…Catechol‐O‐methyltransferase (COMT) is an enzyme that inactivates dopamine and other catecholamines by O‐methylation. Tolcapone, a drug commonly used in the…”
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Abstract 3190: DFMO preferentially drives cancer stem cells in neuroblastoma towards senescence by Avequin, Tracey, Goodyke, Austin, Zagorski, Joseph, Maser, Tyler, Sholler, Giselle L. Saulnier

“…Abstract Background: High-risk neuroblastoma (HRNB) is an aggressive form of the most common extracranial solid tumor cancer in children, often characterized…”
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DIPG-29. DFMO AND PANOBINOSTAT TARGET LIN28 AND HDAC IN DIPG DECREASING CELL VIABILITY by Maser, Tyler, Zagorski, Joseph, VanSickle, Elizabeth, Nagulapally, Abhinav, Sholler, Giselle Saulnier

“…Abstract BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is an aggressive pediatric cancer with a poor prognosis of < 10% overall survival at 2 years from…”
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Abstract 3191: The MDM2 inhibitor CGM097 synergizes with the BET inhibitor OTX015 to induce cell death in neuroblastoma cells by Maser, Tyler P., Zagorski, Joseph W., Goodyke, Austin J., VanSickle, Elizabeth A., Bond, Jeffrey P., Sholler, Giselle L. Saulnier

“…Abstract Background: Neuroblastoma (NB) is the most common extracranial solid tumor in infants and children, with amplification of the oncogene MYCN being a…”
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The Nrf2 activators tBHQ and CDDO-Im have both Nrf2-dependent and – independent effects on human Jurkat T cell activation, as determined by CRISPR-Cas9 gene editing by Zagorski, Joseph Ward, Maser, Tyler P, Liby, Karen T, Rockwell, Cheryl Elizabeth

“…Abstract Nuclear factor erythroid 2-related factor 2 (Nrf2) is a stress activated transcription factor, activated by such stimuli as reactive oxygen and…”
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Determination of the Effects of Nrf2 upon the Early Events of Jurkat T Cell Activation by Use of CRISPR‐CAS9 Mediated Mutation by Zagorski, Joseph, Turley, Alexandra, Maser, Tyler, Rockwell, Cheryl

“…Abstract only Nuclear factor erythroid 2‐related factor 2 (Nrf2) is a transcription factor activated by cell stresses, such as reactive oxygen species and…”
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ETMR-18. TARGETING Lin28 IN ETMR WITH ODC1 INHIBITOR DFMO by Goodyke, Austin, Kelly, Shannon, Zagorski, Joseph, VanSickle, Elizabeth, Maser, Tyler, Sortwell, Caryl, Kemp, Christopher, Nagulapally, Abhinav, Dykema, Karl, Saulnier-Sholler, Giselle

“…Abstract Embryonal tumor with multilayered rosettes (ETMR), is an aggressive brain tumor primarily occurring in young patients (<4 years of age) and…”
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The Nrf2 activator, tBHQ, inhibits IL-2 production by human T cells in a largely Nrf2-independent manner by Zagorski, Joseph Ward, Turley, Alexandra E, Maser, Tyler P, Rockwell, Cheryl Elizabeth

“…Abstract Nrf2 is a transcription factor that is activated by cell stress, such as oxidative insult and exposure to xenobiotics. Upon activation, Nrf2…”
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