Search Results - "Masellis, Mario"
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Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
Published in Nature communications (25-07-2018)“…Magnetic resonance-guided focused ultrasound in combination with intravenously injected microbubbles has been shown to transiently open the blood–brain…”
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A multiomics approach to heterogeneity in Alzheimer's disease: focused review and roadmap
Published in Brain (London, England : 1878) (01-05-2020)“…Aetiological and clinical heterogeneity is increasingly recognized as a common characteristic of Alzheimer's disease and related dementias. This heterogeneity…”
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Gait variability across neurodegenerative and cognitive disorders: Results from the Canadian Consortium of Neurodegeneration in Aging (CCNA) and the Gait and Brain Study
Published in Alzheimer's & dementia (01-08-2021)“…Introduction Gait impairment is common in neurodegenerative disorders. Specifically, gait variability—the stride‐to‐stride fluctuations in distance and…”
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Deconstructing normal pressure hydrocephalus: Ventriculomegaly as early sign of neurodegeneration
Published in Annals of neurology (01-10-2017)“…Idiopathic normal pressure hydrocephalus (NPH) remains both oversuspected on clinical grounds and underconfirmed when based on immediate and sustained response…”
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Neurogenic orthostatic hypotension and supine hypertension in Parkinson's disease and related synucleinopathies: prioritisation of treatment targets
Published in Lancet neurology (01-08-2016)“…Summary Neurogenic orthostatic hypotension and supine hypertension are common manifestations of cardiovascular dysautonomia in Parkinson's disease and related…”
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6
Social inappropriateness in neurodegenerative disorders
Published in International psychogeriatrics (01-02-2018)“…New onset of mood and behavioral changes in middle-aged patients are frequently the first manifestations of an unrecognized neurocognitive disorder. Impairment…”
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Development of cognitive screening test for the severely hearing impaired: Hearing‐impaired MoCA
Published in The Laryngoscope (01-05-2017)“…Objectives To develop a version of the Montreal Cognitive Assessment (MoCA) to be administered to the severely hearing impaired (HI‐MoCA), and to assess its…”
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Imaging biomarkers in Parkinson's disease and Parkinsonian syndromes: current and emerging concepts
Published in Translational neurodegeneration (28-03-2017)“…Two centuries ago in 1817, James Parkinson provided the first medical description of Parkinson's disease, later refined by Jean-Martin Charcot in the…”
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9
Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome
Published in Alzheimer's research & therapy (01-01-2013)“…With increasing knowledge of clinical in vivo biomarkers and the pathological intricacies of Alzheimer's disease (AD), nosology is evolving. Harmonized…”
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10
The spatial coefficient of variation in arterial spin labeling cerebral blood flow images
Published in Journal of cerebral blood flow and metabolism (01-09-2017)“…Macro-vascular artifacts are a common arterial spin labeling (ASL) finding in populations with prolonged arterial transit time (ATT) and result in vascular…”
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The role of high‐field magnetic resonance imaging in parkinsonian disorders: Pushing the boundaries forward
Published in Movement disorders (01-04-2017)“…Historically, magnetic resonance imaging (MRI) has contributed little to the study of Parkinson's disease (PD), but modern MRI approaches have unveiled several…”
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ROOD-MRI: Benchmarking the robustness of deep learning segmentation models to out-of-distribution and corrupted data in MRI
Published in NeuroImage (Orlando, Fla.) (01-09-2023)“…Deep artificial neural networks (DNNs) have moved to the forefront of medical image analysis due to their success in classification, segmentation, and…”
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Molecular imaging to track Parkinson's disease and atypical parkinsonisms: New imaging frontiers
Published in Movement disorders (01-02-2017)“…ABSTRACT Molecular imaging has proven to be a powerful tool for investigation of parkinsonian disorders. One current challenge is to identify biomarkers of…”
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Feasibility of a continuous, multi-sensor remote health monitoring approach in persons living with neurodegenerative disease
Published in Journal of neurology (01-05-2022)“…Background Remote health monitoring with wearable sensor technology may positively impact patient self-management and clinical care. In individuals with…”
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Abnormal network connectivity in frontotemporal dementia: Evidence for prefrontal isolation
Published in Cortex (01-07-2013)“…Degraded social function, disinhibition, and stereotypy are defining characteristics of frontotemporal dementia (FTD), manifesting in both the behavioral…”
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White matter hyperintensities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer’s disease
Published in Alzheimer's research & therapy (13-07-2021)“…Abstract Background We aimed to systematically describe the burden and distribution of white matter hyperintensities (WMH) and investigate correlations with…”
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Enhancement of automated blood flow estimates (ENABLE) from arterial spin‐labeled MRI
Published in Journal of magnetic resonance imaging (01-03-2018)“…Purpose To validate a multiparametric automated algorithm—ENhancement of Automated Blood fLow Estimates (ENABLE)—that identifies useful and poor arterial…”
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Neuroimaging Advances in Parkinson's Disease and Atypical Parkinsonian Syndromes
Published in Frontiers in neurology (15-10-2020)“…Parkinson's disease (PD) and atypical Parkinsonian syndromes are progressive heterogeneous neurodegenerative diseases that share clinical characteristic of…”
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Beta amyloid deposition and cognitive decline in Parkinson’s disease: a study of the PPMI cohort
Published in Molecular brain (13-09-2022)“…Abstract The accumulation of beta amyloid in the brain has a complex and poorly understood impact on the progression of Parkinson’s disease pathology and much…”
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The use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in Alzheimer's disease: the importance of blood-brain barrier penetration and APOE ε4 carrier status
Published in Alzheimer's research & therapy (11-02-2021)“…The antihypertensive angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACE-Is) have similar indications and mechanisms of…”
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