Search Results - "Mascio, Giada"

N-Acetylcysteine causes analgesia in a mouse model of painful diabetic neuropathy by Notartomaso, Serena, Scarselli, Pamela, Mascio, Giada, Liberatore, Francesca, Mazzon, Emanuela, Mammana, Santa, Gugliandolo, Agnese, Cruccu, Giorgio, Bruno, Valeria, Nicoletti, Ferdinando, Battaglia, Giuseppe

“…N-Acetylcysteine, one of the most prescribed antioxidant drugs, enhances pain threshold in rodents and humans by activating mGlu2 metabotropic glutamate…”
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Perineuronal nets are under the control of type-5 metabotropic glutamate receptors in the developing somatosensory cortex by Mascio, Giada, Bucci, Domenico, Notartomaso, Serena, Liberatore, Francesca, Antenucci, Nico, Scarselli, Pamela, Imbriglio, Tiziana, Caruso, Stefano, Gradini, Roberto, Cannella, Milena, Di Menna, Luisa, Bruno, Valeria, Battaglia, Giuseppe, Nicoletti, Ferdinando

“…mGlu5 metabotropic glutamate receptors are highly functional in the early postnatal life, and regulate developmental plasticity of parvalbumin-positive (PV + )…”
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Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain by Notartomaso, Serena, Mascio, Giada, Bernabucci, Matteo, Zappulla, Cristina, Scarselli, Pamela, Cannella, Milena, Imbriglio, Tiziana, Gradini, Roberto, Battaglia, Giuseppe, Bruno, Valeria, Nicoletti, Ferdinando

“…Background L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate…”
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Light-Induced Activation of a Specific Type-5 Metabotropic Glutamate Receptor Antagonist in the Ventrobasal Thalamus Causes Analgesia in a Mouse Model of Breakthrough Cancer Pain by Notartomaso, Serena, Antenucci, Nico, Liberatore, Francesca, Mascio, Giada, Boccadamo Pompili, Stefano Vito, Font, Joan, Scioli, Mariarosaria, Luongo, Livio, Arcella, Antonietta, Gradini, Roberto, Llebaria, Amadeu, Nicoletti, Ferdinando

“…Breakthrough cancer pain (BTcP) refers to a sudden and transient exacerbation of pain, which develops in patients treated with opioid analgesics. Fast-onset…”
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Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia by Nicoletti, Ferdinando, Orlando, Rosamaria, Di Menna, Luisa, Cannella, Milena, Notartomaso, Serena, Mascio, Giada, Iacovelli, Luisa, Matrisciano, Francesco, Fazio, Francesco, Caraci, Filippo, Copani, Agata, Battaglia, Giuseppe, Bruno, Valeria

“…Metabotropic glutamate (mGlu) receptors are considered as candidate drug targets for the treatment of schizophrenia. These receptors form a family of eight…”
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Genetic Deletion of mGlu3 Metabotropic Glutamate Receptors Amplifies Ischemic Brain Damage and Associated Neuroinflammation in Mice by Mastroiacovo, Federica, Zinni, Manuela, Mascio, Giada, Bruno, Valeria, Battaglia, Giuseppe, Pansiot, Julien, Imbriglio, Tiziana, Mairesse, Jerome, Baud, Olivier, Nicoletti, Ferdinando

“…Backgroud: Type-3 metabotropic glutamate (mGlu3) receptors are found in both neurons and glial cells and regulate synaptic transmission, astrocyte function,…”
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Analgesic Activity of Cinnabarinic Acid in Models of Inflammatory and Neuropathic Pain by Notartomaso, Serena, Boccella, Serena, Antenucci, N., Ricciardi, Flavia, Fazio, Francesco, Liberatore, F., Scarselli, P., Scioli, M., Mascio, Giada, Bruno, V., Battaglia, Giuseppe, Nicoletti, Ferdinando, Maione, Sabatino, Luongo, Livio

“…Cinnabarinic acid (CA) is a trace kynurenine metabolite, which activates both type-4 metabotropic glutamate (mGlu4) and arylic hydrocarbon (Ah) receptors. We…”
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mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors by Notartomaso, Serena, Nakao, Harumi, Mascio, Giada, Scarselli, Pamela, Cannella, Milena, Zappulla, Cristina, Madonna, Michele, Motolese, Marta, Gradini, Roberto, Liberatore, Francesca, Zonta, Micaela, Carmignoto, Giorgio, Battaglia, Giuseppe, Bruno, Valeria, Watanabe, Masahiko, Aiba, Atsu, Nicoletti, Ferdinando

“…In cerebellar Purkinje cells (PCs) type-1 metabotropic glutamate (mGlu1) receptors play a key role in motor learning and drive the refinement of synaptic…”
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Targeting mGlu1 Receptors in the Treatment of Motor and Cognitive Dysfunctions in Mice Modeling Type 1 Spinocerebellar Ataxia by Liberatore, Francesca, Antenucci, Nico, Tortolani, Daniel, Mascio, Giada, Fanti, Federico, Sergi, Manuel, Battaglia, Giuseppe, Bruno, Valeria, Nicoletti, Ferdinando, Maccarrone, Mauro, Notartomaso, Serena

“…Type 1 spinocerebellar ataxia (SCA1) is a progressive neurodegenerative disorder with no effective treatment to date. Using mice modeling SCA1, it has been…”
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Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1 by Notartomaso, Serena, Zappulla, Cristina, Biagioni, Francesca, Cannella, Milena, Bucci, Domenico, Mascio, Giada, Scarselli, Pamela, Fazio, Francesco, Weisz, Filippo, Lionetto, Luana, Simmaco, Maurizio, Gradini, Roberto, Battaglia, Giuseppe, Signore, Michele, Puliti, Aldamaria, Nicoletti, Ferdinando

“…Spinocerebellar ataxia type 1 (SCA1) is a genetic disorder characterized by severe ataxia associated with progressive loss of cerebellar Purkinje cells. The…”
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Hypertension Induces Brain β-Amyloid Accumulation, Cognitive Impairment, and Memory Deterioration Through Activation of Receptor for Advanced Glycation End Products in Brain Vasculature by Carnevale, Daniela, Mascio, Giada, DʼAndrea, Ivana, Fardella, Valentina, Bell, Robert D, Branchi, Igor, Pallante, Fabio, Zlokovic, Berislav, Yan, Shirley ShiDu, Lembo, Giuseppe

“…Although epidemiological data associate hypertension with a strong predisposition to develop Alzheimer disease, no mechanistic explanation exists so far. We…”
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A Progressive Build-up of Perineuronal Nets in the Somatosensory Cortex Is Associated with the Development of Chronic Pain in Mice by Mascio, Giada, Notartomaso, Serena, Martinello, Katiuscia, Liberatore, Francesca, Bucci, Domenico, Imbriglio, Tiziana, Cannella, Milena, Antenucci, Nico, Scarselli, Pamela, Lattanzi, Roberta, Bruno, Valeria, Nicoletti, Ferdinando, Fucile, Sergio, Battaglia, Giuseppe

“…Chronic pain is sustained by a maladaptive form of neuronal plasticity occurring in all stations of the pain neuraxis, including cortical regions of the pain…”
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The Trace Kynurenine, Cinnabarinic Acid, Displays Potent Antipsychotic-Like Activity in Mice and Its Levels Are Reduced in the Prefrontal Cortex of Individuals Affected by Schizophrenia by Ulivieri, Martina, Wierońska, Joanna Monika, Lionetto, Luana, Martinello, Katiuscia, Cieslik, Paulina, Chocyk, Agnieszka, Curto, Martina, Di Menna, Luisa, Iacovelli, Luisa, Traficante, Anna, Liberatore, Francesca, Mascio, Giada, Antenucci, Nico, Giannino, Giuseppe, Vergassola, Matteo, Pittaluga, Anna, Bruno, Valeria, Battaglia, Giuseppe, Fucile, Sergio, Simmaco, Maurizio, Nicoletti, Ferdinando, Pilc, Andrzej, Fazio, Francesco

“…Abstract Cinnabarinic acid (CA) is a kynurenine metabolite that activates mGlu4 metabotropic glutamate receptors. Using a highly sensitive ultra-performance…”
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Pharmacological activation of mGlu5 receptors with the positive allosteric modulator VU0360172, modulates thalamic GABAergic transmission by Celli, Roberta, Wall, Mark J., Santolini, Ines, Vergassola, Matteo, Di Menna, Luisa, Mascio, Giada, Cannella, Milena, van Luijtelaar, Gilles, Pittaluga, Anna, Ciruela, Francisco, Bruno, Valeria, Nicoletti, Ferdinando, Ngomba, Richard T.

“…Previous studies have shown that injection of the mGlu5 receptor positive allosteric modulator (PAM) VU0360172 into either the thalamus or somatosensory cortex…”
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Repeated episodes of transient reduction of oxygen exposure simulating aircraft cabin conditions enhance resilience to stress in mice by Ginerete, Roxana Paula, Mascio, Giada, Liberatore, Francesca, Bucci, Domenico, Antenucci, Nico, Di Pietro, Paola, Cannella, Milena, Imbriglio, Tiziana, Notartomaso, Serena, Nicoletti, Ferdinando, Bruno, Valeria, Battaglia, Giuseppe

“…Pilots and crew of domestic flights are exposed to transient periods of mild reductions of partial pressure of inspired oxygen each day, and this might have…”
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Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration by Liberatore, Francesca, Bucci, Domenico, Mascio, Giada, Madonna, Michele, Di Pietro, Paola, Beneventano, Martina, Puliti, Alda Maria, Battaglia, Giuseppe, Bruno, Valeria, Nicoletti, Ferdinando, Romano, Maria Rosaria

“…•We used the monosodium glutamate model in mice to examine the role of mGlu1 receptors in retinal neurodegeneration.•Systemic pharmacological blockade of mGlu1…”
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Common and Rare Variants in TMEM175 Gene Concur to the Pathogenesis of Parkinson’s Disease in Italian Patients by Palomba, Nicole Piera, Fortunato, Giorgio, Pepe, Giuseppe, Modugno, Nicola, Pietracupa, Sara, Damiano, Immacolata, Mascio, Giada, Carrillo, Federica, Di Giovannantonio, Luca Giovanni, Ianiro, Laura, Martinello, Katiuscia, Volpato, Viola, Desiato, Vincenzo, Acri, Riccardo, Storto, Marianna, Nicoletti, Ferdinando, Webber, Caleb, Simeone, Antonio, Fucile, Sergio, Maglione, Vittorio, Esposito, Teresa

“…Parkinson’s disease (PD) represents the most common neurodegenerative movement disorder. We recently identified 16 novel genes associated with PD. In this…”
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X-ray multiscale 3D neuroimaging to quantify cellular aging and neurodegeneration postmortem in a model of Alzheimer’s disease by Barbone, Giacomo E., Bravin, Alberto, Mittone, Alberto, Pacureanu, Alexandra, Mascio, Giada, Di Pietro, Paola, Kraiger, Markus J., Eckermann, Marina, Romano, Mariele, Hrabě de Angelis, Martin, Cloetens, Peter, Bruno, Valeria, Battaglia, Giuseppe, Coan, Paola

“…Purpose Modern neuroimaging lacks the tools necessary for whole-brain, anatomically dense neuronal damage screening. An ideal approach would include unbiased…”
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Role of neuroinflammation in hypertension-induced brain amyloid pathology by Carnevale, Daniela, Mascio, Giada, Ajmone-Cat, Maria Antonietta, D'Andrea, Ivana, Cifelli, Giuseppe, Madonna, Michele, Cocozza, Germana, Frati, Alessandro, Carullo, Pierluigi, Carnevale, Lorenzo, Alleva, Enrico, Branchi, Igor, Lembo, Giuseppe, Minghetti, Luisa

“…Abstract Hypertension and sporadic Alzheimer's disease (AD) have been associated but clear pathophysiological links have not yet been demonstrated…”
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Expression of the K+/Cl− cotransporter, KCC2, in cerebellar Purkinje cells is regulated by group-I metabotropic glutamate receptors by Notartomaso, Serena, Mascio, Giada, Scarselli, Pamela, Martinello, Katiuscia, Fucile, Sergio, Gradini, Roberto, Bruno, Valeria, Battaglia, Giuseppe, Nicoletti, Ferdinando

“…The neuronal K+/Cl− symporter, KCC2, shapes synaptic responses mediated by Cl−-permeant GABAA receptors. Moving from the evidence that excitatory…”
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