Search Results - "Mascia, Francesca"

The Epidermal Growth Factor Receptor System in Skin Repair and Inflammation by Pastore, Saveria, Mascia, Francesca, Mariani, Valentina, Girolomoni, Giampiero

“…The epidermal growth factor (EGF) family comprises multiple mediators such as transforming growth factor-α, amphiregulin, heparin binding-EGF, and epiregulin,…”
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Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy by Mascia, Francesca, Lam, Gary, Keith, Christopher, Garber, Caroline, Steinberg, Seth M, Kohn, Elise, Yuspa, Stuart H

“…Cancer patients treated with anti-EGFR (epidermal growth factor receptor) drugs often develop a dose-limiting pruritic rash of unknown etiology. The aims of…”
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In search of autophagy biomarkers in breast cancer: Receptor status and drug agnostic transcriptional changes during autophagy flux in cell lines by Mascia, Francesca, Mazo, Ilya, Alterovitz, Wei-Lun, Karagiannis, Konstantinos, Wu, Wells W, Shen, Rong-Fong, Beaver, Julia A, Rao, V Ashutosh

“…Autophagy drives drug resistance and drug-induced cancer cell cytotoxicity. Targeting the autophagy process could greatly improve chemotherapy outcomes. The…”
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Cell autonomous or systemic EGFR blockade alters the immune‐environment in squamous cell carcinomas by Mascia, Francesca, Schloemann, Derek T., Cataisson, Christophe, McKinnon, Katherine M., Krymskaya, Ludmila, Wolcott, Karen M., Yuspa, Stuart H.

“…Targeting mutations and amplifications in the EGFR has been successful precision therapy for cancers of the lung, oral cavity and gastrointestinal track…”
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Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21 by Mercurio, Laura, Lulli, Daniela, Mascia, Francesca, Dellambra, Elena, Scarponi, Claudia, Morelli, Martina, Valente, Carola, Carbone, Maria Luigia, Pallotta, Sabatino, Girolomoni, Giampiero, Albanesi, Cristina, Pastore, Saveria, Madonna, Stefania

“…Psoriasis is a chronic Th1/Th17 lymphocytes-mediated inflammatory skin disease, in which epidermal keratinocytes exhibit a peculiar senescent state, resistance…”
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Transcriptomic analysis of pancreatic adenocarcinoma specimens obtained from Black and White patients by Biel, Thomas G, Petrovskaya, Svetlana, Mascia, Francesca, Ju, Tongzhong, Fashoyin-Aje, Lola, Herremans, Kelly M, Riner, Andrea N, Underwood, Patrick W, Gerber, Michael H, Donoghue, Martha, Trevino, Jose G, Rao, V Ashutosh

“…In pancreatic cancer clinical trials, Black patients are under-represented while having higher morbidity and mortality rates as compared to other racial…”
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Blockade of the EGF Receptor Induces a Deranged Chemokine Expression in Keratinocytes Leading to Enhanced Skin Inflammation by Mascia, Francesca, Mariani, Valentina, Girolomoni, Giampiero, Pastore, Saveria

“…During inflammatory skin disorders such as psoriasis, atopic dermatitis, and allergic contact dermatitis, epidermal keratinocytes overexpress large amounts of…”
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ERK1/2 Regulates Epidermal Chemokine Expression and Skin Inflammation by Pastore, Saveria, Mascia, Francesca, Mariotti, Feliciana, Dattilo, Cristina, Mariani, Valentina, Girolomoni, Giampiero

“…Resident cell populations of the skin contribute to the inflammatory response by producing an array of chemokines, which attract leukocytes from the…”
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Gene from a psoriasis susceptibility locus primes the skin for inflammation by Wolf, Ronald, Mascia, Francesca, Dharamsi, Alif, Howard, O M Zack, Cataisson, Christophe, Bliskovski, Val, Winston, Jason, Feigenbaum, Lionel, Lichti, Ulrike, Ruzicka, Thomas, Chavakis, Triantafyllos, Yuspa, Stuart H

“…Psoriasis is a common complex genetic disease characterized by hyperplasia and inflammation in the skin; however, the relative contributions of epidermal cells…”
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The Black Box Illuminated: Signals and Signaling by Mascia, Francesca, Denning, Mitchell, Kopan, Raphael, Yuspa, Stuart H.

“…Unraveling the signaling pathways that transmit information from the cell surface to the nucleus has been a major accomplishment of modern cell and molecular…”
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EGFR Regulates the Expression of Keratinocyte-Derived Granulocyte/Macrophage Colony-Stimulating Factor In Vitro and In Vivo by Mascia, Francesca, Cataisson, Christophe, Lee, Tang-Cheng, Threadgill, David, Mariani, Valentina, Amerio, Paolo, Chandrasekhara, Chinmayi, Souto Adeva, Gema, Girolomoni, Giampiero, Yuspa, Stuart H., Pastore, Saveria

“…Recent advances in the knowledge of the EGFR pathway have revealed its contribution to distinct immune/inflammatory functions of the epidermis. The purpose of…”
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Doxorubicin-induced cardiotoxicity is suppressed by estrous-staged treatment and exogenous 17β-estradiol in female tumor-bearing spontaneously hypertensive rats by Pokrzywinski, Kaytee L, Biel, Thomas G, Rosen, Elliot T, Bonanno, Julia L, Aryal, Baikuntha, Mascia, Francesca, Moshkelani, Delaram, Mog, Steven, Rao, V Ashutosh

“…Doxorubicin (DOX), an anthracycline therapeutic, is widely used to treat a variety of cancer types and known to induce cardiomyopathy in a time and…”
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Stimulation of Purinergic Receptors Modulates Chemokine Expression in Human Keratinocytes by Pastore, Saveria, Mascia, Francesca, Gulinelli, Sara, Forchap, Sylvia, Dattilo, Cristina, Adinolfi, Elena, Girolomoni, Giampiero, Virgilio, Francesco Di, Ferrari, Davide

“…ATP is abundantly released from stressed or damaged cells in response to mechanical stimulation, bacteria, or noxious agents. In this study, we have…”
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Positive regulation of GABAB receptors dually coupled to cyclic AMP by the allosteric agent CGP7930 by ONALI, Pierluigi, MASCIA, Francesca M, OLIANAS, Maria C

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Regulatory role of nitric oxide on monocyte-derived dendritic cell functions by Corinti, Silvia, Pastore, Saveria, Mascia, Francesca, Girolomoni, Giampiero

“…Nitric oxide (NO) has an established role in the defense against bacterial infections and exerts multiple modulatory activities on both inflammatory and immune…”
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GDNF family ligand receptor components Ret and GFRalpha-1 in the human trigeminal ganglion and sensory nuclei by Quartu, Marina, Serra, Maria Pina, Mascia, Francesca, Boi, Marianna, Lai, Maria Letizia, Spano, Alessia, Del Fiacco, Marina

“…The occurrence of Ret and GFRalpha-1 receptors is shown by immunohistochemistry in the human trigeminal sensory system at pre-, postnatal and adult age…”
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Abstract 466: Role of miR-15b-3p in mitoquinone induced autophagy of breast cancer cells by Mascia, Francesca, Pokrzywinski, Kaytee, Rao, Ashutosh

“…Abstract Mitoquinone, a redox-active mitochondrially targeted ubiquinone, activates autophagy more potently in breast cancer cells (MDA-MB-231) than in normal…”
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Abstract 2093: Drug induced autophagy and transcriptional gene expression signatures in breast cancer cell lines by Mascia, Francesca, Karagiannis, Kostantinos, Wu, Wells W., Shen, Rong-Fong, Rao, Ashutosh

“…Abstract Cancer cells can bypass the desired cell death response to chemotherapy through cytoprotective autophagy. In support of this hypothesis, drug…”
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Abstract 2917: Therapeutic targeting of the mitochondria: An evaluation of the transcriptional link between the antioxidant response and autophagy by Pokrzywinski, Kaytee L., Mascia, Francesca, Rao, V. Ashutosh

“…Abstract Mitoquinone (MitoQ), a mitochondrially targeted chemotherapy induces autophagy via excess reactive oxygen species (ROS) production. Elevations in ROS…”
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Infective Endocarditis or Anca Associated Vasculitis: The Importance of a Correct Differential Diagnosis by Bonisoli, Giulio-Luigi, Maiolini, Federica, Croce, Jacopo, Bassanello, Eleonora, Mascia, Francesca, Friso, Simonetta, Tinazzi, Elisa

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