Search Results - "Mascarenhas, Desmond"

Immodulin peptides influence musculoskeletal homeostasis by linking extracellular cues to macrophage and myoblast nuclear receptors by Mascarenhas, Desmond D.

“…Immodulins are synthetic peptides derived from the C-terminal domains of insulin-like growth factor binding proteins (IGFBPs). Immodulins from the 3/5/6 (but…”
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Covalent modification of nephrilin peptide with valproic acid increases its efficacy as a therapeutic in burn trauma by Mascarenhas, Desmond D., Ravikumar, Puja, Amento, Edward P.

“…•Immodulin peptides act as homeostatic rheostats in trauma models.•Immodulins may modify the maturation, differentiation or polarity of monocytes.•Valproic…”
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Epigenetic memory of oxidative stress : does nephrilin exert its protective effects via Rac1? by Mascarenhas, Desmond D, Herndon, David N, Arany, Istvan

“…Notes nephrilin peptide, a designed inhibitor of Rictor complex (mTORC2), exerts pleiotropic protective effects in metabolic, xenobiotic and traumatic stress…”
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Transcriptional re-programming in rat central nervous system two weeks after burn trauma: the impact of nephrilin treatment on the expression of oxidative stress-related genes by Mascarenhas, Desmond D

“…Introduction: Survivors of severe burns suffer lifetime neuroinflammatory consequences manifested by higher incidence of major depression and neurodegenerative…”
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Genetic and Cultural Reconstruction of the Migration of an Ancient Lineage by Sanghera, Dharambir K., Aston, Christopher E., Raina, Anupuma, Mascarenhas, Desmond D.

“…A rare R1a1 Y-haplogroup (Y-HG) L657 clade subtype designated as LPKSTR is found in most male members of a clan of “founder” families within the Goud Saraswat…”
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N-modulin peptides attenuate respiratory distress in a scald-endotoxemia model by Mascarenhas, Desmond D., Ravikumar, Puja, Amento, Edward P.

“…•Burn trauma compromises organ function, glycemic control and immune system.•No approved therapeutic agent exists for these severe systemic effects.•In rodent…”
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Women, innovation, and literature by Mascarenhas, Desmond D, Veer, Sally

“…Background: Avant-garde literature may influence the evolution of social attitudes and meanings. Women purchase the bulk of literary fiction products in the…”
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Insulin-like Growth Factor-independent Effects Mediated by a C-terminal Metal-binding Domain of Insulin-like Growth Factor Binding Protein-3 by Singh, Baljit, Charkowicz, Dona, Mascarenhas, Desmond

“…Insulin-like growth factors (IGFs) play a central role in the integration of proliferative and survival responses of most mammalian cell types. IGF-binding…”
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A nuclear complex of rictor and insulin receptor substrate-2 is associated with albuminuria in diabetic mice by Singh, Baljit K, Singh, Amoolya, Mascarenhas, Desmond D

“…Signaling events associated with diabetic nephropathy are not well understood. Triangulation of events triggered by unrelated bioactive peptides nephrilin and…”
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Effects of the nephrilin peptide on post-burn glycemic control, renal function, fat and lean body mass, and wound healing by Mascarenhas, Desmond D, Ayadi, Amina El, Wetzel, Michael, Prasai, Anesh, Mifflin, Randy, Jay, Jayson, Herndon, David N, Finnerty, Celeste C

“…The mechanisms underlying the effects of severe burn trauma are not well understood. We previously demonstrated the ability of nephrilin peptide (an…”
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Bioactive peptides control receptor for advanced glycated end product-induced elevation of kidney insulin receptor substrate 2 and reduce albuminuria in diabetic mice by Singh, Baljit K, Mascarenhas, Desmond D

“…Sixteen-week-old db/db mice exhibit significantly elevated blood glucose and albuminuria. Kidney mesangial cell matrix expansion and collagen IV synthesis…”
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Nephrilin peptide modulates a neuroimmune stress response in rodent models of burn trauma and sepsis by Mascarenhas, Desmond D, Elayadi, Amina, Singh, Baljit K, Prasai, Anesh, Hegde, Sachin D, Herndon, David N, Finnerty, Celeste C

“…Sepsis occurs three times more often in burns than in other types of trauma, suggesting an overlap or synergy between underlying immune mechanisms in burn…”
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Positive effects of ferric iron on the systemic efficacy of nephrilin peptide in burn trauma by Mascarenhas, Desmond D, El Ayadi, Amina, Ravikumar, Puja, Kang, Gyeong Jin, Langer, Tammy, Moreno, Carlos, Amento, Edward P

“…Introduction: Nephrilin peptide is a designed inhibitor of Rictor complex (also known as mTORC2), an evolutionarily conserved assembly believed to modulate…”
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Genetically transformed maize plants from protoplasts by Rhodes, C.A, Pierce, D.A, Mettler, I.J, Mascarenhas, D, Detmer, J.J

“…Genetically transformed maize plants were obtained from protoplasts treated with recombinant DNA. Protoplasts that were digested from embryogenic cell…”
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Insulin-Like Growth Factor-I Receptor Signaling and Resistance to Trastuzumab (Herceptin) by Lu, Yuhong, Zi, Xiaolin, Zhao, Yunhua, Mascarenhas, Desmond, Pollak, Michael

“…Background: Trastuzumab (Herceptin), an anti-HER2/neu receptor monoclonal antibody that inhibits growth of ErbB2-overexpressing breast cancer, is used to treat…”
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Epigenetic memory of oxidative stress: does nephrilin exert its protective effects via Racl? by Mascarenhas, Desmond D, Herndon, David N, Arany, Istvan

“…Aim: Nephrilin peptide, a designed inhibitor of Rictor complex (mTORC2), exerts pleiotropic protective effects in metabolic, xenobiotic and traumatic stress…”
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Mammalian target of rapamycin complex 2 regulates inflammatory response to stress by Mascarenhas, Desmond, Routt, Sheri, Singh, Baljit K.

“…Objective and design To explore the role of mammalian target of rapamycin 2 (mTORC2) in the activation of inflammatory and oxidative responses in rodent models…”
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Expression of Eukaryotic Proteins in Soluble Form inEscherichia coli by Zhang, Yang, Olsen, David R., Nguyen, Kimyen B., Olson, Pamela S., Rhodes, Eric T., Mascarenhas, Desmond

“…At the optimum temperature for its growth (37°C),Escherichia colitends to accumulate heterologous proteins in insoluble form. Fusion protein technology has…”
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Regional culture and adaptive behavior of physicians by Mascarenhas, Desmond, Singh, Amoolya H.

“…We examine the possibility that regional differentiation of occupations may shed light on how professional behavior adapts to environmental change. Based on…”
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Ribonucleic Acid Polymerase II Binding Subunit 3 (Rpb3), a Potential Nuclear Target of Insulin-Like Growth Factor Binding Protein-3 by Oufattole, Mohammed, Lin, Sally Wan-Jung, Liu, Bingrong, Mascarenhas, Desmond, Cohen, Pinchas, Rodgers, Buel D

“…IGF-binding protein (IGFBP)-3 has intrinsic antiproliferative and proapoptotic functions that are independent of IGF binding and may involve nuclear…”
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