Search Results - "Mascanfroni, Iván D."

Expanding the Universe of Cytokines and Pattern Recognition Receptors: Galectins and Glycans in Innate Immunity by Cerliani, Juan P., Stowell, Sean R., Mascanfroni, Iván D., Arthur, Connie M., Cummings, Richard D., Rabinovich, Gabriel A.

“…Effective immunity relies on the recognition of pathogens and tumors by innate immune cells through diverse pattern recognition receptors (PRRs) that lead to…”
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Antitumor Responses Stimulated by Dendritic Cells Are Improved by Triiodothyronine Binding to the Thyroid Hormone Receptor β by Alamino, Vanina A, Mascanfroni, Iván D, Montesinos, María M, Gigena, Nicolás, Donadio, Ana C, Blidner, Ada G, Milotich, Sonia I, Cheng, Sheue-Yann, Masini-Repiso, Ana M, Rabinovich, Gabriel A, Pellizas, Claudia G

“…Bidirectional cross-talk between the neuroendocrine and immune systems orchestrates immune responses in both physiologic and pathologic settings. In this…”
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17β-Estradiol modulates the prolactin secretion induced by TRH through membrane estrogen receptors via PI3K/Akt in female rat anterior pituitary cell culture by Sosa, Liliana d V, Gutiérrez, Silvina, Petiti, Juan P, Palmeri, Claudia M, Mascanfroni, Iván D, Soaje, Marta, De Paul, Ana L, Torres, Alicia I

“…Considering that estradiol is a major modulator of prolactin (PRL) secretion, the aim of the present study was to analyze the role of membrane estradiol…”
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Nuclear Factor (NF)-κB-dependent Thyroid Hormone Receptor β1 Expression Controls Dendritic Cell Function via Akt Signaling by Mascanfroni, Iván D., del Mar Montesinos, María, Alamino, Vanina A., Susperreguy, Sebastián, Nicola, Juan P., Ilarregui, Juan M., Masini-Repiso, Ana M., Rabinovich, Gabriel A., Pellizas, Claudia G.

“…Despite considerable progress in our understanding of the interplay between immune and endocrine systems, the role of thyroid hormones and their receptors in…”
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Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: Mechanisms and biomedical applications by Mascanfroni, Iván D., Cerliani, Juan P., Dergan-Dylon, Sebastián, Croci, Diego O., Ilarregui, Juan M., Rabinovich, Gabriel A.

“…In spite of their central role in orchestrating immunity, dendritic cells (DCs) can also limit harmful reactions and promote immune tolerance by inducing T…”
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Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors by Croci, Diego O., Cerliani, Juan P., Dalotto-Moreno, Tomas, Méndez-Huergo, Santiago P., Mascanfroni, Ivan D., Dergan-Dylon, Sebastián, Toscano, Marta A., Caramelo, Julio J., García-Vallejo, Juan J., Ouyang, Jing, Mesri, Enrique A., Junttila, Melissa R., Bais, Carlos, Shipp, Margaret A., Salatino, Mariana, Rabinovich, Gabriel A.

“…The clinical benefit conferred by vascular endothelial growth factors (VEGF)-targeted therapies is variable, and tumors from treated patients eventually…”
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Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor by Rothhammer, Veit, Mascanfroni, Ivan D, Bunse, Lukas, Takenaka, Maisa C, Kenison, Jessica E, Mayo, Lior, Chao, Chun-Cheih, Patel, Bonny, Yan, Raymond, Blain, Manon, Alvarez, Jorge I, Kébir, Hania, Anandasabapathy, Niroshana, Izquierdo, Guillermo, Jung, Steffen, Obholzer, Nikolaus, Pochet, Nathalie, Clish, Clary B, Prinz, Marco, Prat, Alexandre, Antel, Jack, Quintana, Francisco J

“…After upregulation of AHR in astrocytes by type I interferons, commensal-microbe-derived metabolites of dietary tryptophan act on astrocytes to suppress CNS…”
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Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses by Farez, Mauricio F., Mascanfroni, Ivan D., Méndez-Huergo, Santiago P., Yeste, Ada, Murugaiyan, Gopal, Garo, Lucien P., Balbuena Aguirre, María E., Patel, Bonny, Ysrraelit, María C., Zhu, Chen, Kuchroo, Vijay K., Rabinovich, Gabriel A., Quintana, Francisco J., Correale, Jorge

“…Seasonal changes in disease activity have been observed in multiple sclerosis, an autoimmune disorder that affects the CNS. These epidemiological observations…”
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Galectin-1 Deactivates Classically Activated Microglia and Protects from Inflammation-Induced Neurodegeneration by Starossom, Sarah C., Mascanfroni, Ivan D., Imitola, Jaime, Cao, Li, Raddassi, Khadir, Hernandez, Silvia F., Bassil, Ribal, Croci, Diego O., Cerliani, Juan P., Delacour, Delphine, Wang, Yue, Elyaman, Wassim, Khoury, Samia J., Rabinovich, Gabriel A.

“…Inflammation-mediated neurodegeneration occurs in the acute and the chronic phases of multiple sclerosis (MS) and its animal model, experimental autoimmune…”
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Endogenous thyrocyte-produced nitric oxide inhibits iodide uptake and thyroid-specific gene expression in FRTL-5 thyroid cells by Fozzatti, Laura, Vélez, María L, Lucero, Ariel M, Nicola, Juan P, Mascanfroni, Iván D, Macció, Daniela R, Pellizas, Claudia G, Roth, Germán A, Masini-Repiso, Ana M

“…Nitric oxide (NO) is a free radical that mediates a wide array of cell functions. It is generated from l-arginine by NO-synthase (NOS). Expression of NOS…”
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Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation by Mayo, Lior, Trauger, Sunia A, Blain, Manon, Nadeau, Meghan, Patel, Bonny, Alvarez, Jorge I, Mascanfroni, Ivan D, Yeste, Ada, Kivisäkk, Pia, Kallas, Keith, Ellezam, Benjamin, Bakshi, Rohit, Prat, Alexandre, Antel, Jack P, Weiner, Howard L, Quintana, Francisco J

“…In multiple sclerosis and experimental autoimmune encephalomyelitis, astrocytes produce lactosylceramide, a glycolipid that promotes astrocyte and microglial…”
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Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function by Shouval, Dror S., Biswas, Amlan, Goettel, Jeremy A., McCann, Katelyn, Conaway, Evan, Redhu, Naresh S., Mascanfroni, Ivan D., Al Adham, Ziad, Lavoie, Sydney, Ibourk, Mouna, Nguyen, Deanna D., Samsom, Janneke N., Escher, Johanna C., Somech, Raz, Weiss, Batia, Beier, Rita, Conklin, Laurie S., Ebens, Christen L., Santos, Fernanda G.M.S., Ferreira, Alexandre R., Sherlock, Mary, Bhan, Atul K., Müller, Werner, Mora, J. Rodrigo, Quintana, Francisco J., Klein, Christoph, Muise, Aleixo M., Horwitz, Bruce H., Snapper, Scott B.

“…Intact interleukin-10 receptor (IL-10R) signaling on effector and T regulatory (Treg) cells are each independently required to maintain immune tolerance. Here…”
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Dexamethasone counteracts the immunostimulatory effects of triiodothyronine (T3) on dendritic cells by Montesinos, María M., Alamino, Vanina A., Mascanfroni, Iván D., Susperreguy, Sebastián, Gigena, Nicolás, Masini-Repiso, Ana M., Rabinovich, Gabriel A., Pellizas, Claudia G.

“…► Effect of dexamethasone (Dex) on triiodothyronine (T3) action in dendritic cells (DC). ► Dex inhibits the immunostimulatory capacity of T3-matured DC. ► Dex…”
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17β-Estradiol stimulates the translocation of endogenous estrogen receptor α at the plasma membrane of normal anterior pituitary cells by Gutiérrez, Silvina, Sosa, Liliana d V., Petiti, Juan P., Mukdsi, Jorge H., Mascanfroni, Iván D., Pellizas, Claudia G., De Paul, Ana L., Cambiasso, María J., Torres, Alicia I.

“…► We show that about 8% of anterior pituitary cells expressed ERα in the plasmalemma. ► Short exposition to E2 and ERα agonist, PPT, increases the membrane ERα…”
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Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α by Mascanfroni, Ivan D, Takenaka, Maisa C, Yeste, Ada, Patel, Bonny, Wu, Yan, Kenison, Jessica E, Siddiqui, Shafiuddin, Basso, Alexandre S, Otterbein, Leo E, Pardoll, Drew M, Pan, Fan, Priel, Avner, Clish, Clary B, Robson, Simon C, Quintana, Francisco J

“…Metabolic changes induced by hypoxia and extracellular ATP, acting through the transcription factors HIF1-α and AHR, regulate the differentiation of type 1…”
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Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39 by Takenaka, Maisa C., Gabriely, Galina, Rothhammer, Veit, Mascanfroni, Ivan D., Wheeler, Michael A., Chao, Chun-Cheih, Gutiérrez-Vázquez, Cristina, Kenison, Jessica, Tjon, Emily C., Barroso, Andreia, Vandeventer, Tyler, de Lima, Kalil Alves, Rothweiler, Sonja, Mayo, Lior, Ghannam, Soufiene, Zandee, Stephanie, Healy, Luke, Sherr, David, Farez, Mauricio F., Prat, Alexandre, Antel, Jack, Reardon, David A., Zhang, Hailei, Robson, Simon C., Getz, Gad, Weiner, Howard L., Quintana, Francisco J.

“…Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls…”
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IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39 by Mascanfroni, Ivan D, Yeste, Ada, Vieira, Silvio M, Burns, Evan J, Patel, Bonny, Sloma, Ido, Wu, Yan, Mayo, Lior, Ben-Hamo, Rotem, Efroni, Sol, Kuchroo, Vijay K, Robson, Simon C, Quintana, Francisco J

“…The immunoregulatory effect of IL-27 is thought to act mainly on T cells. Quintana and colleagues show that IL-27 also converts conventional DCs into…”
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IL-21 induces IL-22 production in CD4+ T cells by Yeste, Ada, Mascanfroni, Ivan D., Nadeau, Meghan, Burns, Evan J., Tukpah, Ann-Marcia, Santiago, Andrezza, Wu, Chuan, Patel, Bonny, Kumar, Deepak, Quintana, Francisco J

“…Interleukin (IL)-22 produced by innate lymphoid cells (ILCs) and CD4+ T cells plays an important role in host defence and mucosal homeostasis, thus it is…”
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Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency by Shouval, Dror S, Biswas, Amlan, Kang, Yu Hui, Griffith, Alexandra E, Konnikova, Liza, Mascanfroni, Ivan D, Redhu, Naresh S, Frei, Sandra M, Field, Michael, Doty, Andria L, Goldsmith, Jeffrey D, Bhan, Atul K, Loizides, Anthony, Weiss, Batia, Yerushalmi, Baruch, Yanagi, Tadahiro, Lui, Xiuli, Quintana, Francisco J, Muise, Aleixo M, Klein, Christoph, Horwitz, Bruce H, Glover, Sarah C, Bousvaros, Athos, Snapper, Scott B

“…Interleukin 10 receptor (IL10R)−deficient mice develop spontaneous colitis and, similarly, patients with loss-of-function mutations in IL10R develop severe…”
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Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2 by Yeste, Ada, Takenaka, Maisa C, Mascanfroni, Ivan D, Nadeau, Meghan, Kenison, Jessica E, Patel, Bonny, Tukpah, Ann-Marcia, Babon, Jenny Aurielle B, DeNicola, Megan, Kent, Sally C, Pozo, David, Quintana, Francisco J

“…Type 1 diabetes (T1D) is a T cell-dependent autoimmune disease that is characterized by the destruction of insulin-producing β cells in the pancreas. The…”
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