Search Results - "Masaya Ono"

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy by Gao, Yang, Nihira, Naoe Taira, Bu, Xia, Chu, Chen, Zhang, Jinfang, Kolodziejczyk, Aleksandra, Fan, Yizeng, Chan, Ngai Ting, Ma, Leina, Liu, Jing, Wang, Dong, Dai, Xiaoming, Liu, Huadong, Ono, Masaya, Nakanishi, Akira, Inuzuka, Hiroyuki, North, Brian J., Huang, Yu-Han, Sharma, Samanta, Geng, Yan, Xu, Wei, Liu, X. Shirley, Li, Lei, Miki, Yoshio, Sicinski, Piotr, Freeman, Gordon J., Wei, Wenyi

“…Immunotherapies that target programmed cell death protein 1 (PD-1) and its ligand PD-L1 as well as cytotoxic T-lymphocyte-associated protein 4 (CTLA4) have…”
Get full text

N‐acetyloxfenicine strongly induces mitohormesis in mice as well as in insects by Matsumura, Takashi, Ono, Masaya, Osada, Satoshi, Matsuhisa, Fumikazu, Ochiai, Masanori, Hayakawa, Yoichi

“…Mitohormesis defines the increase in fitness induced by adaptive responses to mild mitochondrial stress. Here, we show that N‐acetyloxfenicine (NAO) exerted…”
Get full text

The survival and proliferation of osteosarcoma cells are dependent on the mitochondrial BIG3‐PHB2 complex formation by Toki, Shunichi, Yoshimaru, Tetsuro, Matsushita, Yosuke, Aihara, Hitoshi, Ono, Masaya, Tsuneyama, Koichi, Sairyo, Koichi, Katagiri, Toyomasa

“…Previous studies reported the critical role of the brefeldin A–inhibited guanine nucleotide exchange protein 3–prohibitin 2 (BIG3‐PHB2) complex in modulating…”
Get full text

A DDX31/Mutant-p53/EGFR Axis Promotes Multistep Progression of Muscle-Invasive Bladder Cancer by Daizumoto, Kei, Yoshimaru, Tetsuro, Matsushita, Yosuke, Fukawa, Tomoya, Uehara, Hisanori, Ono, Masaya, Komatsu, Masato, Kanayama, Hiro-Omi, Katagiri, Toyomasa

“…The p53 and EGFR pathways are frequently altered in bladder cancer, yet their contributions to its progression remain elusive. Here we report that DEAD box…”
Get full text

The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis by Yoshida, Saishu, Aoki, Katsuhiko, Fujiwara, Ken, Nakakura, Takashi, Kawamura, Akira, Yamada, Kohji, Ono, Masaya, Yogosawa, Satomi, Yoshida, Kiyotsugu

“…Mammalian Hedgehog (Hh) signaling plays key roles in embryogenesis and uniquely requires primary cilia. Functional analyses of several ciliogenesis-related…”
Get full text

Plk1 phosphorylation of CAP-H2 triggers chromosome condensation by condensin II at the early phase of mitosis by Kagami, Yuya, Ono, Masaya, Yoshida, Kiyotsugu

“…Condensin complexes play crucial roles in chromosome condensation that is a fundamental process to establish the “rod-like” shape of chromosome structure in…”
Get full text

The suppressive effect of bacterial-feeding nematodes on hemocyte spreading of Galleria mellonella by Ono, Masaya, Hayakawa, Yoichi, Hama, Yoichiro, Yoshiga, Toyoshi

“…Insect parasitic nematodes have developed a mechanism to escape from the cellular immunity of their insect hosts for successful parasitism. However, the…”
Get full text

Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B + vesicle pathway in liver cancer by Yamada, Kohji, Motohashi, Saya, Oikawa, Tsunekazu, Tago, Naoko, Koizumi, Rei, Ono, Masaya, Tachibana, Toshiaki, Yoshida, Ayano, Yoshida, Saishu, Shimoda, Masayuki, Oka, Masahiro, Yoneda, Yoshihiro, Yoshida, Kiyotsugu

“…Protein secretion in cancer cells defines tumor survival and progression by orchestrating the microenvironment. Studies suggest the occurrence of active…”
Get full text

Ex vivo observation of insect hemocyte behavior against beads and nematodes in the presence of insect plasma by Ono, Masaya, Arimatsu, Chisato, Yoshiga, Toyoshi

“…Recognition of foreign targets by insect hemocytes is a crucial first step for insect immunity against invading multicellular organisms in the hemocoel. To…”
Get full text

Lamin is essential for nuclear localization of the GPI synthesis enzyme PIG-B and GPI-anchored protein production in Drosophila by Yamamoto-Hino, Miki, Kawaguchi, Kohei, Ono, Masaya, Furukawa, Kazuhiro, Goto, Satoshi

“…Membrane lipid biosynthesis is a complex process that occurs in various intracellular compartments. In , phosphatidylinositol glycan-B (PIG-B), which catalyzes…”
Get full text

Proteomic analysis of fatty liver induced by starvation of medaka fish larvae by Ikeda, Tomoyo, Ishikawa, Tokiro, Ninagawa, Satoshi, Okada, Tetsuya, Ono, Masaya, Mori, Kazutoshi

“…When medaka fish (Oryzias latipes) larvae are grown in the absence of exogenous nutrition, the liver becomes dark and positive to Oil Red O staining from 7…”
Get full text

Utility of the Emergency Severity Index by Accuracy of Interrater Agreement by Expert Triage Nurses in a Simulated Scenario in Japan: A Randomized Controlled Trial by Takaoka, Koichi, Ooya, Kensuke, Ono, Masaya, Kakeda, Takahiro

“…The Emergency Severity Index (ESI) is a highly reliable and valid triage scale that is widely used in emergency departments in not only English language…”
Get full text

Upregulation of IGF2R evades lysosomal dysfunction-induced apoptosis of cervical cancer cells via transport of cathepsins by Takeda, Takashi, Komatsu, Masayuki, Chiwaki, Fumiko, Komatsuzaki, Rie, Nakamura, Kanako, Tsuji, Kosuke, Kobayashi, Yusuke, Tominaga, Eiichiro, Ono, Masaya, Banno, Kouji, Aoki, Daisuke, Sasaki, Hiroki

“…Cervical cancer is the most common gynecological malignancy in the world; however, the survival rates of advanced-stage and recurrent cervical cancer patients…”
Get full text

ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation by Atsumi, Yuko, Minakawa, Yusuke, Ono, Masaya, Dobashi, Sachiko, Shinohe, Keitaro, Shinohara, Akira, Takeda, Shunichi, Takagi, Masatoshi, Takamatsu, Nobuhiko, Nakagama, Hitoshi, Teraoka, Hirobumi, Yoshioka, Ken-ichi

“…In response to DNA double-strand breaks (DSBs), H2AX is rapidly phosphorylated at Ser139 to promote DSB repair. Here we show that H2AX is rapidly stabilized in…”
Get full text

NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression by Ohata, Hirokazu, Shiokawa, Daisuke, Obata, Yuuki, Sato, Ai, Sakai, Hiroaki, Fukami, Mayu, Hara, Wakako, Taniguchi, Hirokazu, Ono, Masaya, Nakagama, Hitoshi, Okamoto, Koji

“…Cancer stem cells (CSCs) are associated with the refractory nature of cancer, and elucidating the targetable pathways for CSCs is crucial for devising…”
Get full text

Comparison of cellular encapsulation with nematodes in two lepidopteran insects by Ono, Masaya, Arimatsu, Chisato, Kakinoki, Ayane, Matsunaga, Kazusa, Yoshiga, Toyoshi

“…Encapsulation is an effective cellular immunity feature in insects, but the mechanism by which hemocytes recognize and encapsulate invading nematodes remains…”
Get full text

Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2 by Torii, Satoru, Arakawa, Satoko, Sato, Shigeto, Ishikawa, Kei‐ichi, Taniguchi, Daisuke, Sakurai, Hajime Tajima, Honda, Shinya, Hiraoka, Yuuichi, Ono, Masaya, Akamatsu, Wado, Hattori, Nobutaka, Shimizu, Shigeomi

“…Parkinson's disease (PD) is a common neurodegenerative disorder that results from the loss of dopaminergic neurons. Mutations in…”
Get full text

Traf2- and Nck-Interacting Kinase Is Essential for Wnt Signaling and Colorectal Cancer Growth by SHITASHIGE, Miki, SATOW, Reiko, JIGAMI, Takafumi, AOKI, Kazunori, HONDA, Kazufumi, SHIBATA, Tatsuhiro, ONO, Masaya, HIROHASHI, Setsuo, YAMADA, Tesshi

“…T-cell factor-4 (TCF4) is a transcription factor essential for maintaining the undifferentiated status and self-renewal of intestinal epithelial cells. It has…”
Get full text

Nuclear receptor/Wnt beta-catenin interactions are regulated via differential CBP/p300 coactivator usage by Ono, Masaya, Lai, Keane K Y, Wu, Kaijin, Nguyen, Cu, Lin, David P, Murali, Ramachandran, Kahn, Michael

“…Over 400 million years ago, the evolution of vertebrates gave rise to a life cycle in which the organism began to live longer particularly as an adult. To…”
Get full text

Proteomic approaches to the discovery of cancer biomarkers for early detection and personalized medicine by Honda, Kazufumi, Ono, Masaya, Shitashige, Miki, Masuda, Mari, Kamita, Masahiro, Miura, Nami, Yamada, Tesshi

“…Cancer biomarkers for the early detection of malignancies and selection of therapeutic strategies have been requested in the clinical field. Accurate and…”
Get full text