Search Results - "Masato Kubo"

Innate and adaptive type 2 immunity in lung allergic inflammation by Kubo, Masato

“…Summary Allergic inflammation is a type 2 immune disorder classically characterized by high levels of immunoglobulin E (IgE) and the development of Th2 cells…”
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Mast cells and basophils in allergic inflammation by Kubo, Masato

“…•Mast cells and basophils have similar morphological characteristics and express the high-affinity FceRI on their cell surface.•Genetically engineered deletion…”
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The role of IL-4 derived from follicular helper T (TFH) cells and type 2 helper T (TH2) cells by Kubo, Masato

“…Abstract IL-4 is known to be the quintessential regulatory cytokine, playing a role in a vast number of immune and non-immune functions. This cytokine is…”
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Diurnal Rhythmicity Programs of Microbiota and Transcriptional Oscillation of Circadian Regulator, NFIL3 by Kubo, Masato

“…Circadian rhythms are a very exquisite mechanism to influence on transcriptional levels and physiological activities of various molecules that affect cell…”
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T follicular helper and TH2 cells in allergic responses by Kubo, Masato

“…IL-4 is a cytokine commonly secreted by TH2 and follicular helper T (TFH) cells after antigenic sensitization. TH2 cells have been thought to be the major…”
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The intestinal microbiota regulates body composition through NFIL3 and the circadian clock by Wang, Yuhao, Kuang, Zheng, Yu, Xiaofei, Ruhn, Kelly A., Kubo, Masato, Hooper, Lora V.

“…The intestinal microbiota has been identified as an environmental factor that markedly affects energy storage and body-fat accumulation in mammals, yet the…”
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Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin–basophil axis by Noti, Mario, PhD, Kim, Brian S., MD, Siracusa, Mark C., PhD, Rak, Gregory D., VMD, PhD, Kubo, Masato, PhD, Moghaddam, Amin E., MD, Sattentau, Quentin A., PhD, Comeau, Michael R., BSc, Spergel, Jonathan M., MD, PhD, Artis, David, PhD

“…Background Exposure to food allergens through a disrupted skin barrier has been recognized as a potential factor in the increasing prevalence of food allergy…”
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T follicular helper and T H 2 cells in allergic responses by Kubo, Masato

“…IL-4 is a cytokine commonly secreted by T 2 and follicular helper T (T ) cells after antigenic sensitization. T 2 cells have been thought to be the major…”
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Basophil-Derived Interleukin-4 Controls the Function of Natural Helper Cells, a Member of ILC2s, in Lung Inflammation by Motomura, Yasutaka, Morita, Hideaki, Moro, Kazuyo, Nakae, Susumu, Artis, David, Endo, Takaho A., Kuroki, Yoko, Ohara, Osamu, Koyasu, Shigeo, Kubo, Masato

“…Allergic asthma is an inflammatory disease characterized by lung eosinophilia controlled by type 2 cytokines. Cysteine proteases are potent triggers…”
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Basophil-derived IL-4 promotes epicutaneous antigen sensitization concomitant with the development of food allergy by Hussain, Maryam, MSc, Borcard, Loïc, MSc, Walsh, Kevin P., PhD, Pena Rodriguez, Maria, BSc, Mueller, Christoph, PhD, Kim, Brian S., MD, Kubo, Masato, PhD, Artis, David, PhD, Noti, Mario, PhD

“…Background Exaggerated thymic stromal lymphopoietin (TSLP) production and infiltration of basophils are associated with the pathogenesis of atopic dermatitis…”
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Memory CD8 T cells are vulnerable to chronic IFN-γ signals but not to CD4 T cell deficiency in MHCII-deficient mice by Setoguchi, Ruka, Sengiku, Tomoya, Kono, Hiroki, Kawakami, Eiryo, Kubo, Masato, Yamamoto, Tadashi, Hori, Shohei

“…The mechanisms by which the number of memory CD8 T cells is stably maintained remains incompletely understood. It has been postulated that maintaining them…”
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Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells by Miyauchi, Kosuke, Adachi, Yu, Tonouchi, Keisuke, Yajima, Taiki, Harada, Yasuyo, Fukuyama, Hidehiro, Deno, Senka, Iwakura, Yoichiro, Yoshimura, Akihiko, Hasegawa, Hideki, Yugi, Katsuyuki, Fujii, Shin-ichiro, Ohara, Osamu, Takahashi, Yoshimasa, Kubo, Masato

“…Influenza viruses are a major public health problem. Vaccines are the best available countermeasure to induce effective immunity against infection with…”
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Tumor-infiltrating CD62L+PD-1-CD8 T cells retain proliferative potential via Bcl6 expression and replenish effector T cells within the tumor by Gong, Yu, Suzuki, Toshihiro, Kozono, Haruo, Kubo, Masato, Nakano, Naoko

“…Tumor antigen–primed CD8 T cells differentiate into effector T cells that kill tumor cells rapidly, whereas durable responses of CD8 T cells are required to…”
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Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy by Kondo, Taisuke, Morita, Rimpei, Okuzono, Yuumi, Nakatsukasa, Hiroko, Sekiya, Takashi, Chikuma, Shunsuke, Shichita, Takashi, Kanamori, Mitsuhiro, Kubo, Masato, Koga, Keiko, Miyazaki, Takahiro, Kassai, Yoshiaki, Yoshimura, Akihiko

“…Adoptive T-cell immunotherapy is a promising approach to cancer therapy. Stem cell memory T (T SCM ) cells have been proposed as a class of long-lived and…”
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Basophils promote innate lymphoid cell responses in inflamed skin by Kim, Brian S, Wang, Kelvin, Siracusa, Mark C, Saenz, Steven A, Brestoff, Jonathan R, Monticelli, Laurel A, Noti, Mario, Tait Wojno, Elia D, Fung, Thomas C, Kubo, Masato, Artis, David

“…Type 2 inflammation underlies allergic diseases such as atopic dermatitis, which is characterized by the accumulation of basophils and group 2 innate lymphoid…”
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Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity by Tanaka, Shinya, Ise, Wataru, Inoue, Takeshi, Ito, Ayako, Ono, Chisato, Shima, Yoshihito, Sakakibara, Shuhei, Nakayama, Manabu, Fujii, Kentaro, Miura, Ikuo, Sharif, Jafar, Koseki, Haruhiko, Koni, Pandelakis A., Raman, Indu, Li, Quan-Zhen, Kubo, Masato, Fujiki, Katsunori, Nakato, Ryuichiro, Shirahige, Katsuhiko, Araki, Hiromitsu, Miura, Fumihito, Ito, Takashi, Kawakami, Eiryo, Baba, Yoshihiro, Kurosaki, Tomohiro

“…A contribution of epigenetic modifications to B cell tolerance has been proposed but not directly tested. Here we report that deficiency of ten–eleven…”
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Mathematical modeling of atopic dermatitis reveals “double-switch” mechanisms underlying 4 common disease phenotypes by Domínguez-Hüttinger, Elisa, PhD, Christodoulides, Panayiotis, MEng, Miyauchi, Kosuke, PhD, Irvine, Alan D., MD, DSc, Okada-Hatakeyama, Mariko, PhD, Kubo, Masato, PhD, Tanaka, Reiko J., PhD

“…Background The skin barrier acts as the first line of defense against constant exposure to biological, microbial, physical, and chemical environmental…”
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IL-17A as an Inducer for Th2 Immune Responses in Murine Atopic Dermatitis Models by Nakajima, Saeko, Kitoh, Akihiko, Egawa, Gyohei, Natsuaki, Yohei, Nakamizo, Satoshi, Moniaga, Catharina Sagita, Otsuka, Atsushi, Honda, Tetsuya, Hanakawa, Sho, Amano, Wataru, Iwakura, Yoichiro, Nakae, Susumu, Kubo, Masato, Miyachi, Yoshiki, Kabashima, Kenji

“…Atopic dermatitis (AD) is generally regarded as a type 2 helper T (Th2)-mediated inflammatory skin disease. Although the number of IL-17A-producing cells is…”
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Critical role of p38 and GATA3 in natural helper cell function by Furusawa, Jun-ichi, Moro, Kazuyo, Motomura, Yasutaka, Okamoto, Kazuo, Zhu, Jinfang, Takayanagi, Hiroshi, Kubo, Masato, Koyasu, Shigeo

“…Natural helper (NH) cells, a member of Lin(-)IL-2R(+)IL-7R(+)IL-25R(+)IL-33R(+)GATA3(+) group 2 innate lymphoid cell subset, are characterized by the…”
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The role of B cells in COVID-19 infection and vaccination by Chen, Shiru, Guan, Fei, Candotti, Fabio, Benlagha, Kamel, Camara, Niels Olsen Saraiva, Herrada, Andres A., James, Louisa K., Lei, Jiahui, Miller, Heather, Kubo, Masato, Ning, Qin, Liu, Chaohong

“…B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the…”
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