Search Results - "Masashi Sakurai"

A pilot clinical study of the therapeutic antibody against canine PD-1 for advanced spontaneous cancers in dogs by Igase, Masaya, Nemoto, Yuki, Itamoto, Kazuhito, Tani, Kenji, Nakaichi, Munekazu, Sakurai, Masashi, Sakai, Yusuke, Noguchi, Shunsuke, Kato, Masahiro, Tsukui, Toshihiro, Mizuno, Takuya

“…Inhibition of programmed death 1 (PD-1), expressed on activated T cells, can break through immune resistance and elicit durable responses in human melanoma as…”
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Establishment of new mouse model for allergic dermatitis showing severe fibrosis by YAMADA, Yusuke, YOSHIZAKI, Kyoko, SAKURAI, Masashi, MORIMOTO, Masahiro

“…Allergic dermatitis (AD) is a skin disease characterized by a chronic inflammation caused by immune dysregulation. In the histopathology of patients with AD,…”
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Age-related alterations in protein phosphatase 2A methylation levels in brains of cynomolgus monkeys: a pilot study by Ando, Sana, Sakurai, Masashi, Shibutani, Shusaku, Kimura, Nobuyuki, Shimozawa, Nobuhiro, Yasutomi, Yasuhiro, Yabe, Ryotaro, Ohama, Takashi, Sato, Koichi

“…The abnormal activity of PP2A, a dominant member of type 2A serine/threonine protein phosphatase, has been implicated in the development of Alzheimer's disease…”
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Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder by Sakurai, Masashi, Yamamoto, Yasuko, Kanayama, Noriyo, Hasegawa, Masaya, Mouri, Akihiro, Takemura, Masao, Matsunami, Hidetoshi, Miyauchi, Tomoya, Tokura, Tatsuya, Kimura, Hiroyuki, Ito, Mikiko, Umemura, Eri, (Boku), Aiji Sato, Nagashima, Wataru, Tonoike, Takashi, Kurita, Kenichi, Ozaki, Norio, Nabeshima, Toshitaka, Saito, Kuniaki

“…Previous reports have shown that during chronic inflammation, the tryptophan (TRP)-kynurenine (KYN) pathway plays a pivotal role in the onset of depression…”
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Minocycline prevents depression‐like behavior in streptozotocin‐induced diabetic mice by Sakurai, Masashi, Iwasa, Ryoi, Sakai, Yusuke, Morimoto, Masahiro

“…Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia. Diabetic patients are known to have a higher prevalence and a higher risk of…”
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Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis by Enjoji, Shuhei, Yabe, Ryotaro, Tsuji, Shunya, Yoshimura, Kazuhiro, Kawasaki, Hideyoshi, Sakurai, Masashi, Sakai, Yusuke, Takenouchi, Hiroko, Yoshino, Shigefumi, Hazama, Shoichi, Nagano, Hiroaki, Oshima, Hiroko, Oshima, Masanobu, Vitek, Michael P, Matsuura, Tetsuya, Hippo, Yoshitaka, Usui, Tatsuya, Ohama, Takashi, Sato, Koichi

“…Gastric cancer is the fifth most common malignancy and the third leading cause of cancer-related deaths worldwide. Chemotherapies against gastric cancer often…”
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Alteration of specific cytokine expression patterns in patients with breast cancer by Kawaguchi, Kosuke, Sakurai, Masashi, Yamamoto, Yasuko, Suzuki, Eiji, Tsuda, Moe, Kataoka, Tatsuki R., Hirata, Masahiro, Nishie, Mariko, Nojiri, Takashi, Kumazoe, Motofumi, Saito, Kuniaki, Toi, Masakazu

“…Systemic inflammation has been associated with aggressive tumor growth, invasion, and metastasis. Here we performed a comprehensive analysis of 26 kinds of…”
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Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture by Usui, Tatsuya, Sakurai, Masashi, Umata, Koji, Elbadawy, Mohamed, Ohama, Takashi, Yamawaki, Hideyuki, Hazama, Shoichi, Takenouchi, Hiroko, Nakajima, Masao, Tsunedomi, Ryouichi, Suzuki, Nobuaki, Nagano, Hiroaki, Sato, Koichi, Kaneda, Masahiro, Sasaki, Kazuaki

“…Colorectal cancer is one of the most common causes of cancer death worldwide. In patients with metastatic colorectal cancer, combination treatment with several…”
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Establishment of a dog primary prostate cancer organoid using the urine cancer stem cells by Usui, Tatsuya, Sakurai, Masashi, Nishikawa, Shimpei, Umata, Koji, Nemoto, Yuki, Haraguchi, Tomoya, Itamoto, Kazuhito, Mizuno, Takuya, Noguchi, Shunsuke, Mori, Takashi, Iwai, Satomi, Nakagawa, Takayuki, Yamawaki, Hideyuki, Ohama, Takashi, Sato, Koichi

“…Dog spontaneously develop prostate cancer (PC) like humans. Because most dogs with PC have a poor prognosis, they could be used as a translational model for…”
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FKBP52 and FKBP51 differentially regulate the stability of estrogen receptor in breast cancer by Habara, Makoto, Sato, Yuki, Goshima, Takahiro, Sakurai, Masashi, Imai, Hiroyuki, Shimizu, Hideyuki, Katayama, Yuta, Hanaki, Shunsuke, Masaki, Takahiro, Morimoto, Masahiro, Nishikawa, Sayaka, Toyama, Tatsuya, Shimada, Midori

“…Estrogen receptor α (ERα) is a transcription factor that induces cell proliferation and exhibits increased expression in a large subset of breast cancers. The…”
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Cross-reactivity of anti-human programmed cell death ligand 1 (PD-L1) monoclonal antibody, clone 28-8 against feline PD-L1 by NISHIBORI, Shoma, SAKURAI, Masashi, KAGAWA, Yumiko, UCHIDA, Kazuyuki, NAKAGAWA, Takayuki, IGASE, Masaya, MIZUNO, Takuya

“…Immunotherapy is a breakthrough in human cancer therapy and has become a major concern in veterinary oncology. However, in cats, many unclear points of the…”
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Nippostrongylus brasiliensis infection inhibits hippocampal neurogenesis in mice by Sakurai, Masashi, Kurachi, Junya, Sakai, Yusuke, Morimoto, Masahiro

“…The brain has long been considered a site of “immune privilege”; however, recent evidence indicates the presence of brain–immune interactions in physiological…”
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Histopathological Characterization of Cases of Spontaneous Fatal Feline Severe Fever with Thrombocytopenia Syndrome, Japan by Sakai, Yusuke, Kuwabara, Yuko, Ishijima, Keita, Kagimoto, Saya, Mura, Serina, Tatemoto, Kango, Kuwata, Ryusei, Yonemitsu, Kenzo, Minami, Shohei, Kuroda, Yudai, Baba, Kenji, Okuda, Masaru, Shimoda, Hiroshi, Sakurai, Masashi, Morimoto, Masahiro, Maeda, Ken

“…Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tickborne infectious disease caused by SFTS virus (SFTSV). We report 7 cases of spontaneous…”
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Mycobacterial infection induces eosinophilia and production of α-defensin by eosinophils in mice by KHATUN, Afia, SAKURAI, Masashi, SAKAI, Yusuke, TACHIBANA, Masato, OHARA, Naoya, MORIMOTO, Masahiro

“…It has been well known in humans that eosinophil infiltration into the site of inflammation and eosinophilia occur in mycobacterial infections. However, the…”
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Demonstration of the Clathrin- and Caveolin-Mediated Endocytosis at the Maternal–Fetal Barrier in Mouse Placenta after Intravenous Administration of Gold Nanoparticles by RATTANAPINYOPITUK, Kasem, SHIMADA, Akinori, MORITA, Takehito, SAKURAI, Masashi, ASANO, Atsushi, HASEGAWA, Tatsuya, INOUE, Kenichiro, TAKANO, Hirohisa

“…Exposure to nanoparticles during pregnancy is a public concern, because nanoparticles may pass from the mother to the fetus across the placenta. The purpose of…”
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Enhanced neurogenesis and possible synaptic reorganization in the piriform cortex of adult rat following kainic acid‐induced status epilepticus by Sakurai, Masashi, Suzuki, Hiroko, Tomita, Nagi, Sunden, Yuji, Shimada, Akinori, Miyata, Hajime, Morita, Takehito

“…Epileptic seizure has been reported to enhance adult neurogenesis and induce aberrant synaptic reorganization in the human dentate gyrus in the hippocampal…”
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Proof-of-concept study of the caninized anti-canine programmed death 1 antibody in dogs with advanced non-oral malignant melanoma solid tumors by Igase, Masaya, Inanaga, Sakuya, Nishibori, Shoma, Itamoto, Kazuhito, Sunahara, Hiroshi, Nemoto, Yuki, Tani, Kenji, Horikirizono, Hiro, Nakaichi, Munekazu, Baba, Kenji, Kambayashi, Satoshi, Okuda, Masaru, Sakai, Yusuke, Sakurai, Masashi, Kato, Masahiro, Tsukui, Toshihiro, Mizuno, Takuya

“…The anti-programmed death 1 (PD-1) antibody has led to durable clinical responses in a wide variety of human tumors. We have previously developed the caninized…”
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Detection of α-defensin in eosinophils in helminth-infected mouse model by KHATUN, Afia, SAKURAI, Masashi, OKADA, Kazuki, SAKAI, Yusuke, MORIMOTO, Masahiro

“…α-defensin is a potent antimicrobial peptide secreted from intestinal mucosal epithelial cells, such as Paneth cells, and affects not only bacteria but also…”
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Neurolymphomatosis in a cat by SAKURAI, Masashi, AZUMA, Kazushi, NAGAI, Arata, FUJIOKA, Toru, SUNDEN, Yuji, SHIMADA, Akinori, MORITA, Takehito

“…A 9-year-old male mixed breed cat showed chronic progressive neurological symptoms, which are represented by ataxia and seizures. At necropsy, spinal roots and…”
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Lethal severe fever with thrombocytopenia syndrome virus infection causes systemic germinal centre failure and massive T cell apoptosis in cats by Sakai, Yusuke, Mura, Serina, Kuwabara, Yuko, Kagimoto, Saya, Sakurai, Masashi, Morimoto, Masahiro, Park, Eun-Sil, Shimojima, Masayuki, Nagata, Noriyo, Ami, Yasushi, Yoshikawa, Tomoki, Iwata-Yoshikawa, Naoko, Fukushi, Shuetsu, Watanabe, Shumpei, Kurosu, Takeshi, Okutani, Akiko, Kimura, Masanobu, Imaoka, Koichi, Saijo, Masayuki, Morikawa, Shigeru, Suzuki, Tadaki, Maeda, Ken

“…Severe fever with thrombocytopenia syndrome (SFTS) is a fatal viral disease characterized by high fever, thrombocytopenia, leukopenia, and multi-organ…”
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