Search Results - "Masaki Tomishima"

Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors by Chino, Ayaka, Seo, Ryushi, Amano, Yasushi, Namatame, Ichiji, Hamaguchi, Wataru, Honbou, Kazuya, Mihara, Takuma, Yamazaki, Mayako, Tomishima, Masaki, Masuda, Naoyuki

“…In this study, we report the identification of potent pyrimidoindazoles as phosphodiesterase10A (PDE10A) inhibitors by using the method of fragment-based drug…”
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Total Synthesis of Chloropeptin II (Complestatin) and Chloropeptin I by Garfunkle, Joie, Kimball, F. Scott, Trzupek, John D., Takizawa, Shinobu, Shimamura, Hiroyuki, Tomishima, Masaki, Boger, Dale L.

“…The first total synthesis of chloropeptin II (1, complestatin) is disclosed. Key elements of the approach include the use of an intramolecular Larock indole…”
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Novel echinocandin antifungals. Part 2: Optimization of the side chain of the natural product FR901379. Discovery of micafungin by Tomishima, Masaki, Ohki, Hidenori, Yamada, Akira, Maki, Katsuyuki, Ikeda, Fumiaki

“…Further optimization of the potent antifungal activity of side chain analogs of the natural product FR901379 led to the discovery of compound 8 (micafungin)…”
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In Vitro Activities of a New Lipopeptide Antifungal Agent, FK463, against a Variety of Clinically Important Fungi by TAWARA, S, IKEDA, F, KAWABATA, K, TAKASUGI, H, SAKANE, K, TANAKA, H, MATSUMOTO, F, KUWAHARA, S, MAKI, K, MORISHITA, Y, OTOMO, K, TERATANI, N, GOTO, T, TOMISHIMA, M, OHKI, H, YAMADA, A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Novel echinocandin antifungals. Part 1: Novel side-chain analogs of the natural product FR901379 by Tomishima, Masaki, Ohki, Hidenori, Yamada, Akira, Maki, Katsuyuki, Ikeda, Fumiaki

“…A series of novel acylated analogs of the novel water-soluble echinocandin FR901379 have been prepared. Compound 3c shows both potent antifungal activity and…”
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Use of a serum-based antifungal susceptibility assay to predict the in vivo efficacy of novel echinocandin compounds by Maki, Katsuyuki, Matsumoto, Satoru, Watabe, Etsuko, Iguchi, Yumi, Tomishima, Masaki, Ohki, Hidenori, Yamada, Akira, Ikeda, Fumiaki, Tawara, Shuichi, Mutoh, Seitaro

“…ABSTRACT In vitro susceptibility assays of antifungal activity do not always accurately predict in vivo efficacy. As well as having a clear clinical…”
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FK463, a novel water-soluble echinocandin lipopeptide: synthesis and antifungal activity by Tomishima, M, Ohki, H, Yamada, A, Takasugi, H, Maki, K, Tawara, S, Tanaka, H

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Determination of Antifungal Activities in Serum Samples from Mice Treated with Different Antifungal Drugs Allows Detection of an Active Metabolite of Itraconazole by Maki, Katsuyuki, Watabe, Etsuko, Iguchi, Yumi, Nakamura, Hideko, Tomishima, Masaki, Ohki, Hidenori, Yamada, Akira, Matsumoto, Satoru, Ikeda, Fumiaki, Tawara, Shuichi, Mutoh, Seitaro

“…To establish an in vitro method of predicting in vivo efficacy of antifungal drugs against Candida albicans and Aspergillus fumigatus, the antifungal…”
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Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability by Chino, Ayaka, Masuda, Naoyuki, Amano, Yasushi, Honbou, Kazuya, Mihara, Takuma, Yamazaki, Mayako, Tomishima, Masaki

“…In this study, we report the identification of potent benzimidazoles as PDE10A inhibitors. We first identified imidazopyridine 1 as a high-throughput screening…”
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Synthesis, SAR study, and biological evaluation of novel 2,3-dihydro-1H-imidazo[1,2-a]benzimidazole derivatives as phosphodiesterase 10A inhibitors by Chino, Ayaka, Honda, Shugo, Morita, Masataka, Yonezawa, Koichi, Hamaguchi, Wataru, Amano, Yasushi, Moriguchi, Hiroyuki, Yamazaki, Mayako, Aota, Masaki, Tomishima, Masaki, Masuda, Naoyuki

“…[Display omitted] Phosphodiesterase 10A (PDE10A) inhibitors were designed and synthesized based on the dihydro-imidazobenzimidazole scaffold. Compound 5a…”
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Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors by Ayaka Chino, Ryushi Seo, Yasushi Amano, Ichiji Namatame, Wataru Hamaguchi, Kazuya Honbou, Takuma Mihara, Mayako Yamazaki, Masaki Tomishima, Naoyuki Masuda

“…In this study, we report the identification of potent pyrimidoindazoles as phosphodiesterase10A (PDE10A) inhibitors by using the method of fragment-based drug…”
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Synthesis and antifungal activity of ASP9726, a novel echinocandin with potent Aspergillus hyphal growth inhibition by Morikawa, Hiroshi, Tomishima, Masaki, Kayakiri, Natsuko, Araki, Takanobu, Barrett, David, Akamatsu, Souichirou, Matsumoto, Satoru, Uchida, Satoko, Nakai, Toru, Takeda, Shinobu, Maki, Katsuyuki

“…The synthesis and antifungal activity of ASP9726, a novel echinocandin with potent Aspergillus hyphal growth inhibition and significantly improved MIC against…”
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FR290581, a novel sordarin derivative: Synthesis and antifungal activity by Hanadate, Tadaatsu, Tomishima, Masaki, Shiraishi, Nobuyuki, Tanabe, Daisuke, Morikawa, Hiroshi, Barrett, David, Matsumoto, Satoru, Ohtomo, Kazumi, Maki, Katsuyuki

“…We have discovered the novel sordarin derivative FR290581, which exhibited superior activity, a good pharmacokinetic profile and good in vivo activity…”
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Synthesis and evaluation of nitro 5-deazaflavins as novel bioreductive antitumor agents by Kawamoto, Tetsuji, Ikeuchi, Yoshihiro, Hiraki, Junko, Eikyu, Yoshiteru, Shimizu, Kazue, Tomishima, Masaki, Bessho, Kiyoshi, Yoneda, Fumio, Mikata, Yuji, Nishida, Mamiko, Ikehara, Kenji, Sasaki, Takuma

“…A series of nitro 5-deazaflavins, 5-deazaflavins possessing a nitro group at C(6)–C(9) position, has been designed and synthesized as a novel class of…”
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Atropisomeric Flavoenzyme Models with a Modified Pyrimidine Ring:  Syntheses, Physical Properties, and Stereochemistry in the Reactions with NAD(P)H Analogs by Ohno, Atsuyoshi, Kunitomo, Jun, Kawai, Yasushi, Kawamoto, Tetsuji, Tomishima, Masaki, Yoneda, Fumio

“…Optically active 5-deazaflavin derivatives (3-aryl-10-(4-tert-butylphenyl)pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione) with an axial chirality at the pyrimidine…”
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Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins by Kawamoto, Tetsuji, Ikeuchi, Yoshihiro, Hiraki, Junko, Eikyu, Yoshiteru, Shimizu, Kazue, Tomishima, Masaki, Bessho, Kiyoshi, Yoneda, Fumio, Mikata, Yuji, Nishida, Mamiko, Ikehara, Kenji

“…Cytotoxicities of nitro 5-deazaflavins were evaluated in vitro towards hypoxic and oxic Chinese hamster cells (V79). 6-Nitro and 8-nitro derivatives were…”
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