Search Results - "Masai, Hisao"

TT-pocket/HIRAN: binding to 3′-terminus of DNA for recognition and processing of stalled replication forks by Masai, Hisao

“…Abstract Stalled replication forks need to be swiftly detected and protected from collapse and the cause for fork stall be removed to restore the active…”
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Building up the machinery for DNA replication by Masai, Hisao

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Regulation of HP1 protein by phosphorylation during transcriptional repression and cell cycle by Oki, Masaya, Masai, Hisao

“…Abstract HP1 (heterochromatin protein 1), a key factor for the formation of heterochromatin, binds to the methylated lysine 9 of histone H3 (H3K9me) and…”
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Claspin is Required for Growth Recovery from Serum Starvation through Regulating the PI3K-PDK1-mTOR Pathway in Mammalian Cells by Yang, Chi-Chun, Masai, Hisao

“…Claspin plays multiple important roles in regulation of DNA replication as a mediator for the cellular response to replication stress, an integral replication…”
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A Personal Reflection on the Replicon Theory: From R1 Plasmid to Replication Timing Regulation in Human Cells by Masai, Hisao

“…Fifty years after the Replicon Theory was originally presented, detailed mechanistic insight into prokaryotic replicons has been obtained and rapid progress is…”
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Oligomer formation and G-quadruplex binding by purified murine Rif1 protein, a key organizer of higher-order chromatin architecture by Moriyama, Kenji, Yoshizawa-Sugata, Naoko, Masai, Hisao

“…Rap1-interacting protein 1 (Rif1) regulates telomere length in budding yeast. We previously reported that, in metazoans and fission yeast, Rif1 also plays…”
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Rif1 regulates the replication timing domains on the human genome by Yamazaki, Satoshi, Ishii, Aii, Kanoh, Yutaka, Oda, Masako, Nishito, Yasumasa, Masai, Hisao

“…DNA replication is spatially and temporally regulated during S‐phase. DNA replication timing is established in early‐G1‐phase at a point referred to as timing…”
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Eukaryotic chromosome DNA replication: where, when, and how? by Masai, Hisao, Matsumoto, Seiji, You, Zhiying, Yoshizawa-Sugata, Naoko, Oda, Masako

“…DNA replication is central to cell proliferation. Studies in the past six decades since the proposal of a semiconservative mode of DNA replication have…”
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Assembly, Activation, and Helicase Actions of MCM2-7: Transition from Inactive MCM2-7 Double Hexamers to Active Replication Forks by You, Zhiying, Masai, Hisao

“…In this review, we summarize the processes of the assembly of multi-protein replisomes at the origins of replication. Replication licensing, the loading of…”
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Rif1 is a global regulator of timing of replication origin firing in fission yeast by Hayano, Motoshi, Kanoh, Yutaka, Matsumoto, Seiji, Renard-Guillet, Claire, Shirahige, Katsuhiko, Masai, Hisao

“…One of the long-standing questions in eukaryotic DNA replication is the mechanisms that determine where and when a particular segment of the genome is…”
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Cdc7 activates replication checkpoint by phosphorylating the Chk1-binding domain of Claspin in human cells by Yang, Chi-Chun, Kato, Hiroyuki, Shindo, Mayumi, Masai, Hisao

“…Replication checkpoint is essential for maintaining genome integrity in response to various replication stresses as well as during the normal growth. The…”
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Replication timing regulation of eukaryotic replicons: Rif1 as a global regulator of replication timing by Yamazaki, Satoshi, Hayano, Motoshi, Masai, Hisao

“…Origins of DNA replication on eukaryotic genomes have been observed to fire during S phase in a coordinated manner. Studies in yeast indicate that origin…”
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Extracellular DJ-1 induces sterile inflammation in the ischemic brain by Nakamura, Koutarou, Sakai, Seiichiro, Tsuyama, Jun, Nakamura, Akari, Otani, Kento, Kurabayashi, Kumiko, Yogiashi, Yoshiko, Masai, Hisao, Shichita, Takashi

“…Inflammation is implicated in the onset and progression of various diseases, including cerebral pathologies. Here, we report that DJ-1, which plays a role…”
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Human Tim/Timeless-interacting Protein, Tipin, Is Required for Efficient Progression of S Phase and DNA Replication Checkpoint by Yoshizawa-Sugata, Naoko, Masai, Hisao

“…Tipin was originally isolated as a protein interacting with Timeless/Tim1/Tim (Tim), which is known to be involved in both circadian rhythm and cell cycle…”
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Both a Unique Motif at the C Terminus and an N-Terminal HEAT Repeat Contribute to G-Quadruplex Binding and Origin Regulation by the Rif1 Protein by Kobayashi, Shunsuke, Fukatsu, Rino, Kanoh, Yutaka, Kakusho, Naoko, Matsumoto, Seiji, Chaen, Shigeru, Masai, Hisao

“…Rif1 is a key factor for spatiotemporal regulation of DNA replication. Rif1 suppresses origin firing in the mid-late replication domains by generating…”
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Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression by Sakaue-Sawano, Asako, Kurokawa, Hiroshi, Morimura, Toshifumi, Hanyu, Aki, Hama, Hiroshi, Osawa, Hatsuki, Kashiwagi, Saori, Fukami, Kiyoko, Miyata, Takaki, Miyoshi, Hiroyuki, Imamura, Takeshi, Ogawa, Masaharu, Masai, Hisao, Miyawaki, Atsushi

“…The cell-cycle transition from G 1 to S phase has been difficult to visualize. We have harnessed antiphase oscillating proteins that mark cell-cycle…”
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Discovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers by Irie, Takayuki, Asami, Tokiko, Sawa, Ayako, Uno, Yuko, Taniyama, Chika, Funakoshi, Yoko, Masai, Hisao, Sawa, Masaaki

“…CDC7, a serine-threonine kinase, plays conserved and important roles in regulation of DNA replication and has been recognized as a potential anticancer target…”
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Regulation and roles of Cdc7 kinase under replication stress by Yamada, Masayuki, Masai, Hisao, Bartek, Jiri

“…Cdc7 (cell division cycle 7) kinase together with its activation subunit ASK (also known as Dbf4) play pivotal roles in DNA replication and contribute also to…”
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Catalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types by Sun, Wendi, Lee, Kian Leong, Poellinger, Lorenz, Masai, Hisao, Kato, Hiroyuki

“…The histone H3K27 demethylase, UTX/KDM6A, plays a critical role in the early development of vertebrates, and mutations are frequently found in various cancers…”
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Epigenetic Regulation of the Blimp-1 Gene (Prdm1) in B Cells Involves Bach2 and Histone Deacetylase 3 by Tanaka, Hiromu, Muto, Akihiko, Shima, Hiroki, Katoh, Yasutake, Sax, Nicolas, Tajima, Shinya, Brydun, Andrey, Ikura, Tsuyoshi, Yoshizawa, Naoko, Masai, Hisao, Hoshikawa, Yutaka, Noda, Tetsuo, Nio, Masaki, Ochiai, Kyoko, Igarashi, Kazuhiko

“…B lymphocyte-induced maturation protein 1 (Blimp-1) encoded by Prdm1 is a master regulator of plasma cell differentiation. The transcription factor Bach2…”
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