Improvement of Psoriasis by Alteration of the Gut Environment by Oral Administration of Fucoidan from Cladosiphon Okamuranus

Psoriasis is a chronic autoimmune inflammatory disease for which there is no cure; it results in skin lesions and has a strong negative impact on patients' quality of life. Fucoidan from is a dietary seaweed fiber with immunostimulatory effects. The present study reports that the administration...

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Bibliographic Details
Published in:	Marine drugs Vol. 18; no. 3; p. 154
Main Authors:	Takahashi, Masanobu, Takahashi, Kento, Abe, Sunao, Yamada, Kosuke, Suzuki, Manami, Masahisa, Mai, Endo, Mari, Abe, Keiko, Inoue, Ryo, Hoshi, Hiroko
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 10-03-2020 MDPI
Subjects:	Adaptor Proteins, Signal Transducing - drug effects Algae Animals Cecum Dermatitis Diet Digestive system Disease Fecal microflora Feces Feces - microbiology Fucoidan Gastrointestinal Microbiome - drug effects Gastrointestinal tract Genomes iga Ileum Immune system Immunity Immunoglobulin A Immunoglobulin A - biosynthesis Immunological diseases Immunostimulants Immunostimulation Inflammatory diseases Intestine Intestine, Small - drug effects Intestine, Small - microbiology Itching Lesions Mice Microbiota Microorganisms Mucin Mucins - biosynthesis Mutants Mutation Oral administration Phaeophyceae - chemistry Polysaccharides - chemistry Polysaccharides - therapeutic use Pruritus Pruritus - drug therapy Pruritus - psychology Psoriasis Psoriasis - drug therapy Psoriasis - psychology Quality of life Scratching Seaweeds Signs and symptoms Skin Skin diseases Skin lesions Symptoms traf3ip2 Tumor necrosis factor Tumor necrosis factor receptors microbiota IgA fucoidan mucin psoriasis Traf3ip2
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Summary:	Psoriasis is a chronic autoimmune inflammatory disease for which there is no cure; it results in skin lesions and has a strong negative impact on patients' quality of life. Fucoidan from is a dietary seaweed fiber with immunostimulatory effects. The present study reports that the administration of fucoidan provided symptomatic relief of facial itching and altered the gut environment in the TNF receptor-associated factor 3-interacting protein 2 ( ) mutant mice ( mice); the mutation was responsible for psoriasis in the mouse model used in this study. A fucoidan diet ameliorated symptoms of psoriasis and decreased facial scratching. In fecal microbiota analysis, the fucoidan diet drastically altered the presence of major intestinal opportunistic microbiota. At the same time, the fucoidan diet increased mucin volume in ileum and feces, and IgA contents in cecum. These results suggest that dietary fucoidan may play a significant role in the prevention of dysfunctional immune diseases by improving the intestinal environment and increasing the production of substances that protect the immune system.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1660-3397 1660-3397
DOI:	10.3390/md18030154