Search Results - "Marzo, Vincenzo"

New approaches and challenges to targeting the endocannabinoid system by Di Marzo, Vincenzo

“…Dysregulation of the endocannabinoid system has been implicated in numerous diseases, particularly pain, psychiatric and neurological disorders, but…”
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Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight by Di Marzo, Vincenzo

“…This Perspective discusses concepts in endocannabinoid signaling that have come to light with the recent development of pharmacological and genetic tools for…”
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The effect of cannabichromene on adult neural stem/progenitor cells by Shinjyo, Noriko, Di Marzo, Vincenzo

“…Apart from the psychotropic compound Δ9-tetrahydrocannabinol (THC), evidence suggests that other non-psychotropic phytocannabinoids are also of potential…”
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Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis by Everard, Amandine, Plovier, Hubert, Rastelli, Marialetizia, Van Hul, Matthias, de Wouters d’Oplinter, Alice, Geurts, Lucie, Druart, Céline, Robine, Sylvie, Delzenne, Nathalie M., Muccioli, Giulio G., de Vos, Willem M., Luquet, Serge, Flamand, Nicolas, Di Marzo, Vincenzo, Cani, Patrice D.

“…Variations in N -acylethanolamines (NAE) levels are associated with obesity and metabolic comorbidities. Their role in the gut remains unclear. Therefore, we…”
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Endocannabinoids and energy homeostasis: An update by Cristino, Luigia, Becker, Thorsten, Di Marzo, Vincenzo

“…The endocannabinoid system (ECS) is a widespread intercellular signaling system that plays a critical role in energy homeostasis, meant as the precise matching…”
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Cannabinoids and the expanded endocannabinoid system in neurological disorders by Cristino, Luigia, Bisogno, Tiziana, Di Marzo, Vincenzo

“…Anecdotal evidence that cannabis preparations have medical benefits together with the discovery of the psychotropic plant cannabinoid Δ 9 -tetrahydrocannabinol…”
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An introduction to the endocannabinoid system: from the early to the latest concepts by De Petrocellis, Luciano, Di Marzo, Vincenzo, PhD

“…A rather complex and pleiotropic endogenous signalling system was discovered in the late 1990s, starting from studies on the mechanism of action of Δ9…”
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Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years by Maccarrone, Mauro, Di Marzo, Vincenzo, Gertsch, Jürg, Grether, Uwe, Howlett, Allyn C, Hua, Tian, Makriyannis, Alexandros, Piomelli, Daniele, Ueda, Natsuo, van der Stelt, Mario

“…The cannabis derivative marijuana is the most widely used recreational drug in the Western world and is consumed by an estimated 83 million individuals (∼3% of…”
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The Endocannabinoid System in Energy Homeostasis and the Etiopathology of Metabolic Disorders by Silvestri, Cristoforo, Di Marzo, Vincenzo

“…Endocannabinoids and cannabinoid CB1 receptors are known to play a generalized role in energy homeostasis. However, clinical trials with the first generation…”
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New role for the anandamide metabolite prostaglandin F2α ethanolamide: Rolling preadipocyte proliferation by Boubertakh, Besma, Courtemanche, Olivier, Marsolais, David, Di Marzo, Vincenzo, Silvestri, Cristoforo

“…White adipose tissue regulation is key to metabolic health, yet still perplexing. The chief endocannabinoid anandamide metabolite, prostaglandin F2α…”
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The endocannabinoid system and its therapeutic exploitation by Marzo, Vincenzo Di, Bifulco, Maurizio, Petrocellis, Luciano De

“…The term 'endocannabinoid' - originally coined in the mid-1990s after the discovery of membrane receptors for the psychoactive principle in Cannabis,…”
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NMR Spectroscopic Method to Identify and Classify Thiol-Trapping Agents: Revival of Michael Acceptors for Drug Discovery by Avonto, Cristina, Taglialatela-Scafati, Orazio, Pollastro, Federica, Minassi, Alberto, Di Marzo, Vincenzo, De Petrocellis, Luciano, Appendino, Giovanni

“…Speed trap: Cysteamine reacts in DMSO with electrophilic double bonds to afford Michael adducts (see scheme), whereas no trapping reaction takes place in…”
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Bisphenol A Induces Fatty Liver by an Endocannabinoid-Mediated Positive Feedback Loop by Martella, Andrea, Silvestri, Cristoforo, Maradonna, Francesca, Gioacchini, Giorgia, Allarà, Marco, Radaelli, Giuseppe, Overby, Darryl R, Di Marzo, Vincenzo, Carnevali, Oliana

“…The xenoestrogen bisphenol A (BPA) is a widespread plasticizer detectable within several ecosystems. BPA is considered a metabolic disruptor, affecting…”
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From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology by Ligresti, Alessia, De Petrocellis, Luciano, Di Marzo, Vincenzo

“…Apart from having been used and misused for at least four millennia for, among others, recreational and medicinal purposes, the cannabis plant and its most…”
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Adolescent exposure to THC in female rats disrupts developmental changes in the prefrontal cortex by Rubino, Tiziana, Prini, Pamela, Piscitelli, Fabiana, Zamberletti, Erica, Trusel, Massimo, Melis, Miriam, Sagheddu, Claudia, Ligresti, Alessia, Tonini, Raffaella, Di Marzo, Vincenzo, Parolaro, Daniela

“…Abstract Current concepts suggest that exposure to THC during adolescence may act as a risk factor for the development of psychiatric disorders later in life…”
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TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications by Starowicz, Katarzyna, Cristino, Luigia, Di Marzo, Vincenzo

“…Increasing evidence exists to support the presence of functional transient receptor potential vanilloid type 1 (TRPV1) channels in the brain, where these…”
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The endocannabinoid system: Its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation by Di Marzo, Vincenzo

“…The endocannabinoid signalling system includes: (1) at least two G-protein-coupled receptors, known as the cannabinoid CB 1 and CB 2 receptors and discovered…”
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Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease by Borrelli, Francesca, Fasolino, Ines, Romano, Barbara, Capasso, Raffaele, Maiello, Francesco, Coppola, Diana, Orlando, Pierangelo, Battista, Giovanni, Pagano, Ester, Di Marzo, Vincenzo, Izzo, Angelo A.

“…Inflammatory bowel disease (IBD) is an incurable disease which affects millions of people in industrialized countries. Anecdotal and scientific evidence…”
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The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations by Petrosino, Stefania, Di Marzo, Vincenzo

“…Palmitoylethanolamide (PEA) has emerged as a potential nutraceutical, because this compound is naturally produced in many plant and animal food sources, as…”
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Circulating endocannabinoidome signatures of disease activity in amyotrophic lateral sclerosis by Dubbioso, Raffaele, Iannotti, Fabio Arturo, Senerchia, Gianmaria, Verde, Roberta, Iuzzolino, Valentina Virginia, Spisto, Myriam, Fasolino, Ines, Manganelli, Fiore, Di Marzo, Vincenzo, Piscitelli, Fabiana

“…Background and purpose Preclinical studies of amyotrophic lateral sclerosis (ALS) have shown altered endocannabinoid (eCB) signalling that may contribute to…”
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