Search Results - "Marzabadi, Mohammad R."

Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist by Forray, Carlos, Borowsky, Beth, Durkin, Margaret M, Ogozalek, Kristine, Marzabadi, Mohammad R, DeLeon, John, Heurich, Rainer, Lichtblau, Harvey, Shaposhnik, Zoya, Daniewska, Irena, Blackburn, Thomas P, Branchek, Theresa A, Gerald, Christophe, Vaysse, Pierre J

“…Melanin concentrating hormone (MCH) is an orexigenic hypothalamic neuropeptide, which plays an important role in the complex regulation of energy balance and…”
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Discovery of Lu AA33810: A highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder by Packiarajan, Mathivanan, Marzabadi, Mohammad R., Desai, Mahesh, Lu, Yalei, Noble, Stewart A., Wong, Wai C., Jubian, Vrej, Chandrasena, Gamini, Wolinsky, Toni D., Zhong, Hualing, Walker, Mary W., Wiborg, Ove, Andersen, Kim

“…The structure–activity relationship of a series of tricyclic-sulfonamide compounds 11–32 culminating in the discovery of…”
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5-(2′-Pyridyl)-2-aminothiazoles: Alkyl amino sulfonamides and sulfamides as potent NPY₅ antagonists by Packiarajan, Mathivanan, Coate, Heather, Desai, Mahesh, Jimenez, Hermogenes N, Reinhard, Emily J, Jubian, Vrej J, Marzabadi, Mohammad R, Chandrasena, Gamini, Wolinski, Toni C, Walker, Mary W, Andersen, Kim

“…Synthesis, SAR and physico-chemical properties of an alkyl aminothiazole series 8 and 16 are described. 2-Pyridylaminothiazole based compounds such as 8c and…”
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N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists by Wu, Lingyun, Lu, Kai, Desai, Mahesh, Packiarajan, Mathivanan, Joshi, Amita, Marzabadi, Mohammad R., Jubian, Vrej, Andersen, Kim, Chandrasena, Gamini, Boyle, Noel J., Walker, Mary W.

“…Subtype specific ligands are needed to evaluate the therapeutic potential of modulating the brain’s neuropeptide Y system. The benzothiazepine glycinamide 1a…”
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Intramolecular anodic olefin coupling reactions: a useful method for carbon-carbon bond formation by Hudson, Christine M, Marzabadi, Mohammad R, Moeller, Kevin D, New, Dallas G

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Synthesis and SAR Investigations for Novel Melanin-Concentrating Hormone 1 Receptor (MCH1) Antagonists Part 1. The Discovery of Arylacetamides as Viable Replacements for the Dihydropyrimidinone Moiety of an HTS Hit by Jiang, Yu, Chen, Chien-An, Lu, Kai, Daniewska, Irena, De Leon, John, Kong, Ron, Forray, Carlos, Li, Boshan, Hegde, Laxminarayan G, Wolinsky, Toni D, Craig, Douglas A, Wetzel, John M, Andersen, Kim, Marzabadi, Mohammad R

“…Melanin-concentrating hormone (MCH) is involved in the regulation of feeding, water balance, energy metabolism, general arousal and attention state, memory,…”
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Synthesis and SAR Investigations for Novel Melanin-Concentrating Hormone 1 Receptor (MCH1) Antagonists Part 2:  A Hybrid Strategy Combining Key Fragments of HTS Hits by Chen, Chien-An, Jiang, Yu, Lu, Kai, Daniewska, Irena, Mazza, Christine G, Negron, Leonardo, Forray, Carlos, Parola, Tony, Li, Boshan, Hegde, Laxminarayan G, Wolinsky, Toni D, Craig, Douglas A, Kong, Ron, Wetzel, John M, Andersen, Kim, Marzabadi, Mohammad R

“…A novel series of melanin-concentrating hormone (MCH1) receptor antagonists based on combining key fragments from the high-throughput screening (HTS) hits…”
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The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity by Walker, Mary W, Wolinsky, Toni D, Jubian, Vrej, Chandrasena, Gamini, Zhong, Huailing, Huang, Xinyan, Miller, Silke, Hegde, Laxminarayan G, Marsteller, Douglas A, Marzabadi, Mohammad R, Papp, Mariusz, Overstreet, David H, Gerald, Christophe P G, Craig, Douglas A

“…Neuropeptide Y (NPY) regulates physiological processes via receptor subtypes (Y(1), Y(2), Y(4), Y(5), and y(6)). The Y(5) receptor is well known for its role…”
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Anodic amide oxidations in the presence of electron-rich phenyl rings: evidence for an intramolecular electron-transfer mechanism by Moeller, Kevin D, Wang, Po W, Tarazi, Sharif, Marzabadi, Mohammad R, Wong, Poh Lee

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Design and Synthesis of Novel α1a Adrenoceptor-Selective Dihydropyridine Antagonists for the Treatment of Benign Prostatic Hyperplasia by Nagarathnam, Dhanapalan, Wetzel, John M, Miao, Shou Wu, Marzabadi, Mohammad R, Chiu, George, Wong, Wai C, Hong, Xingfang, Fang, James, Forray, Carlos, Branchek, Theresa A, Heydorn, William E, Chang, Raymond S. L, Broten, Theodore, Schorn, Terry W, Gluchowski, Charles

“…We report the synthesis and evaluation of novel α1a adrenoceptor subtype-selective antagonists. Systematic modification of the lipophilic…”
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Oxidative organic electrochemistry: a novel intramolecular coupling of electron-rich olefins by Moeller, Kevin D, Marzabadi, Mohammad R, New, Dallas G, Chiang, Michael Y, Keith, Shari

“…Oxidative cyclization reactions are of interest because they allow for the generation of carbon-carbon bonds and the formation of rings without a loss in the…”
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Chlorine dioxide oxidation of amines: synthetic utility and a biomimetic synthesis of elaeocarpidine by Chen, Chien Kuang, Hortmann, Alfred G, Marzabadi, Mohammad R

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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 3. Approaches To Eliminate Opioid Agonist Metabolites by Using Substituted Phenylpiperazine Side Chains by Lagu, Bharat, Tian, Dake, Nagarathnam, Dhanapalan, Marzabadi, Mohammad R, Wong, Wai C, Miao, Shou W, Zhang, Fengqi, Sun, Wanying, Chiu, George, Fang, James, Forray, Carlos, Chang, Raymond S. L, Ransom, Richard W, Chen, Tsing B, O'Malley, Stacey, Zhang, Kanyin, Vyas, Kamlesh P, Gluchowski, Charles

“…Dihydropyrimidinones, such as 1, represent a novel class of α1a adrenoceptor antagonists with potential for the treatment of benign prostatic hyperplasia (BPH)…”
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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 4. Structure−Activity Relationship in the Dihydropyrimidine Series by Wong, Wai C, Sun, Wanying, Lagu, Bharat, Tian, Dake, Marzabadi, Mohammad R, Zhang, Fengqi, Nagarathnam, Dhanapalan, Miao, Shou W, Wetzel, John M, Peng, Jian, Forray, Carlos, Chang, Raymond S. L, Chen, Tsing B, Ransom, Richard, O'Malley, Stacey, Broten, Theodore P, Kling, Paul, Vyas, Kamlesh P, Zhang, Kanyin, Gluchowski, Charles

“…We have previously disclosed dihydropyridines such as 1a,b as selective α1a antagonists as a potential treatment for benign prostatic hyperplasia (BPH). The…”
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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 1. Structure−Activity Relationship in Dihydropyrimidinones by Nagarathnam, Dhanapalan, Miao, Shou Wu, Lagu, Bharat, Chiu, George, Fang, James, Murali Dhar, T. G, Zhang, Jack, Tyagarajan, Sriram, Marzabadi, Mohammad R, Zhang, Fengqi, Wong, Wai C, Sun, Wanying, Tian, Dake, Wetzel, John M, Forray, Carlos, Chang, Raymond S. L, Broten, Theodore P, Ransom, Richard W, Schorn, Terry W, Chen, Tsing B, O'Malley, Stacey, Kling, Paul, Schneck, Kathryn, Bendesky, Robert, Harrell, Charles M, Vyas, Kamlesh P, Gluchowski, Charles

“…Dihydropyrimidinones such as compound 12 exhibited high binding affinity and subtype selectivity for the cloned human α1a receptor. Systematic modifications of…”
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Identification of a Dihydropyridine as a Potent α1a Adrenoceptor-Selective Antagonist That Inhibits Phenylephrine-Induced Contraction of the Human Prostate by Wong, Wai C, Chiu, George, Wetzel, John M, Marzabadi, Mohammad R, Nagarathnam, Dhanapalan, Wang, Diana, Fang, James, Miao, Shou Wu, Hong, Xingfang, Forray, Carlos, Vaysse, Pierre J.-J, Branchek, Theresa A, Gluchowski, Charles, Tang, Rui, Lepor, Herbert

“…A number of novel dihydropyridine derivatives based upon…”
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5-(2'-Pyridyl)-2-aminothiazoles: Alkyl amino sulfonamides and sulfamides as potent NPY sub(5 antagonists) by Packiarajan, Mathivanan, Coate, Heather, Desai, Mahesh, Jimenez, Hermogenes N, Reinhard, Emily J, Jubian, Vrej J, Marzabadi, Mohammad R, Chandrasena, Gamini, Wolinski, Toni C, Walker, Mary W, Andersen, Kim

“…Synthesis, SAR and physico-chemical properties of an alkyl aminothiazole series 8 and 16 are described. 2-Pyridylaminothiazole based compounds such as 8c and…”
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5-(2′-Pyridyl)-2-aminothiazoles: Alkyl amino sulfonamides and sulfamides as potent NPY 5 antagonists by Packiarajan, Mathivanan, Coate, Heather, Desai, Mahesh, Jimenez, Hermogenes N., Reinhard, Emily J., Jubian, Vrej J., Marzabadi, Mohammad R., Chandrasena, Gamini, Wolinski, Toni C., Walker, Mary W., Andersen, Kim

“…Synthesis, SAR and physico-chemical properties of an alkyl aminothiazole series 8 and 16 are described. 2-Pyridylaminothiazole based compounds such as 8c and…”
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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones by Nagarathnam, D, Miao, S W, Lagu, B, Chiu, G, Fang, J, Murali Dhar, T G, Zhang, J, Tyagarajan, S, Marzabadi, M R, Zhang, F, Wong, W C, Sun, W, Tian, D, Wetzel, J M, Forray, C, Chang, R S, Broten, T P, Ransom, R W, Schorn, T W, Chen, T B, O'Malley, S, Kling, P, Schneck, K, Bendesky, R, Harrell, C M

“…Dihydropyrimidinones such as compound 12 exhibited high binding affinity and subtype selectivity for the cloned human alpha(1a) receptor. Systematic…”
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5-(2'-Pyridyl)-2-aminothiazoles: alkyl amino sulfonamides and sulfamides as potent NPY(5) antagonists by Packiarajan, Mathivanan, Coate, Heather, Desai, Mahesh, Jimenez, Hermogenes N, Reinhard, Emily J, Jubian, Vrej J, Marzabadi, Mohammad R, Chandrasena, Gamini, Wolinski, Toni C, Walker, Mary W, Andersen, Kim

“…Synthesis, SAR and physico-chemical properties of an alkyl aminothiazole series 8 and 16 are described. 2-Pyridylaminothiazole based compounds such as 8c and…”
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