Search Results - "Marzabadi, M R"

Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis by David, D J, Klemenhagen, K C, Holick, K A, Saxe, M D, Mendez, I, Santarelli, L, Craig, D A, Zhong, H, Swanson, C J, Hegde, L G, Ping, X I, Dong, D, Marzabadi, M R, Gerald, C P, Hen, R

“…Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide that plays a role in the modulation of food intake and mood. In rodents, the actions of MCH…”
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Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist by Forray, Carlos, Borowsky, Beth, Durkin, Margaret M, Ogozalek, Kristine, Marzabadi, Mohammad R, DeLeon, John, Heurich, Rainer, Lichtblau, Harvey, Shaposhnik, Zoya, Daniewska, Irena, Blackburn, Thomas P, Branchek, Theresa A, Gerald, Christophe, Vaysse, Pierre J

“…Melanin concentrating hormone (MCH) is an orexigenic hypothalamic neuropeptide, which plays an important role in the complex regulation of energy balance and…”
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Design and synthesis of novel dihydropyridine alpha-1A antagonists by Marzabadi, Mohammad R., Xingfang Hong, Nagarathnam, Dhanapalan, ShouWu Miao, Chiu, George, Wong, Wai C., Wetzel, John M., Fang, James, Forray, Carlos, Chen, Tsing B., O'Malley, Stacey S., Chang, Raymond S.L., Gluchowski, Charles

“…A series of analogs of SNAP 5150 containing heteroatoms at C 2 or C 6 positions is described. Herein, we report that the presence of alkyl substituted…”
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Effect of ferric iron and desferrioxamine on lipofuscin accumulation in cultured rat heart myocytes by Marzabadi, M R, Sohal, R S, Brunk, U T

“…The general objective of this study was to examine the role of oxidative stress and transition metal catalysis in lipofuscinogenesis in postmitotic cells…”
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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones by Nagarathnam, D, Miao, S W, Lagu, B, Chiu, G, Fang, J, Murali Dhar, T G, Zhang, J, Tyagarajan, S, Marzabadi, M R, Zhang, F, Wong, W C, Sun, W, Tian, D, Wetzel, J M, Forray, C, Chang, R S, Broten, T P, Ransom, R W, Schorn, T W, Chen, T B, O'Malley, S, Kling, P, Schneck, K, Bendesky, R, Harrell, C M

“…Dihydropyrimidinones such as compound 12 exhibited high binding affinity and subtype selectivity for the cloned human alpha(1a) receptor. Systematic…”
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Indenoindole depresses lipofuscin formation in cultured neonatal rat myocardial cells by Marzabadi, Massoud R., Jones, Charles, Rydström, Jan

“…Lipofuscin accumulation in cultured rat myocardial cells is considered an index of intra-lysosomal oxidative reactions and was registered by autofluorescence…”
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Water and ion distributions in myocytes cultured under oxidative stress mimic changes found in the process of aging by von Zglinicki, T, Marzabadi, M R, Roomans, G M

“…Element concentrations and local water content were measured in cytoplasm, nuclei, mitochondria and lipofuscin granula (LG) of isolated cardiac myocytes of the…”
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Steady-state kinetic evaluation of the reverse reaction for Escherichia coli 5-enolpyruvoylshikimate-3-phosphate synthase by Gruys, K J, Marzabadi, M R, Pansegrau, P D, Sikorski, J A

“…Recently it has been found that the kinetic mechanism for Escherichia coli 5-enolpyruvoylshikimate-3-phosphate synthase (EPSPS) in the forward direction is…”
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Heavy metals and lipofuscinogenesis. A study on myocardial cells cultured under varying oxidative stress by Marzabadi, M R, Jones, C B

“…The aim of this study was to examine the influence on lipofuscinogenesis of a number of transition and non-transition heavy metals in cultured post-mitotic…”
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Mechanisms of lipofuscinogenesis: effect of the inhibition of lysosomal proteinases and lipases under varying concentrations of ambient oxygen in cultured rat neonatal myocardial cells by Marzabadi, M R, Sohal, R S, Brunk, U T

“…The objective of this study was to analyse the relative roles of oxidative stress and lysosomal lytic enzymes in lipofuscin formation in cultured neonatal rat…”
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Effect of ethanol on lipofuscin accumulation in cultured rat cardiac myocytes by Sohal, R S, Marzabadi, M R, Brunk, U T

“…The objective of this study was to determine the effect of ethanol on in vitro life span, rate of contraction and lipofuscin content of neonatal rat cardiac…”
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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety by Murali Dhar, T G, Nagarathnam, D, Marzabadi, M R, Lagu, B, Wong, W C, Chiu, G, Tyagarajan, S, Miao, S W, Zhang, F, Sun, W, Tian, D, Shen, Q, Zhang, J, Wetzel, J M, Forray, C, Chang, R S, Broten, T P, Schorn, T W, Chen, T B, O'Malley, S, Ransom, R, Schneck, K, Bendesky, R, Harrell, C M, Vyas, K P

“…We have previously described compound 1a as a high-affinity subtype selective alpha(1a) antagonist. In vitro and in vivo evaluation of compound 1a showed its…”
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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains by Lagu, B, Tian, D, Nagarathnam, D, Marzabadi, M R, Wong, W C, Miao, S W, Zhang, F, Sun, W, Chiu, G, Fang, J, Forray, C, Chang, R S, Ransom, R W, Chen, T B, O'Malley, S, Zhang, K, Vyas, K P, Gluchowski, C

“…Dihydropyrimidinones, such as 1, represent a novel class of alpha(1a) adrenoceptor antagonists with potential for the treatment of benign prostatic hyperplasia…”
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Effect of alpha-tocopherol and some metal chelators on lipofuscin accumulation in cultured neonatal rat cardiac myocytes by Marzabadi, M R, Sohal, R S, Brunk, U T

“…The objective of this study was to test further the hypothesis that oxidative stress is a major causal factor in lipofuscin formation. We have previously shown…”
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Spermine prevent iron accumulation and depress lipofuscin accumulation in cultured myocardial cells by Marzabadi, Massoud R., Løvaas, Erik

“…The present work demonstrates that spermine prevents aging in cultured myocytes exposed to oxidative stress. It is found that physiological levels of spermine…”
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Effect of ambient oxygen concentration on lipofuscin accumulation in cultured rat heart myocytes--a novel in vitro model of lipofuscinogenesis by Sohal, R S, Marzabadi, M R, Galaris, D, Brunk, U T

“…The objective of this study was to elucidate the factors involved in the accumulation of lipofuscin in post-mitotic cells. The hypothesis that oxidative stress…”
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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series by Wong, W C, Sun, W, Lagu, B, Tian, D, Marzabadi, M R, Zhang, F, Nagarathnam, D, Miao, S W, Wetzel, J M, Peng, J, Forray, C, Chang, R S, Chen, T B, Ransom, R, O'Malley, S, Broten, T P, Kling, P, Vyas, K P, Zhang, K, Gluchowski, C

“…We have previously disclosed dihydropyridines such as 1a,b as selective alpha(1a) antagonists as a potential treatment for benign prostatic hyperplasia (BPH)…”
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Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist by Borowsky, B, Durkin, M.M, Ogozalek, K, Marzabadi, M.R, DeLeon, J, Heurich, R, Lichtblau, H, Shaposhnik, Z, Daniewska, I, Blackburn, T.P, Branchek, T.A, Gerald, C, Vaysse, P.J, Forray, C

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An EPSP Synthase Inhibitor Joining Shikimate 3-Phosphate with Glyphosate:  Synthesis and Ligand Binding Studies by Marzabadi, Mohammad R., Gruys, Kenneth J., Pansegrau, Paul D., Walker, Mark C., Yuen, Henry K., Sikorski, James A.

“…A novel EPSP synthase inhibitor 4 has been designed and synthesized to probe the configurational details of glyphosate recognition in its herbicidal ternary…”
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ClO2 oxidation of amines: synthetic utility and a biomimetic synthesis of elaeocarpidine by CHIEN-KUANG CHEN, HORTMANN, A. G, MARZABADI, M. R

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