Search Results - "Mary N Teruel"

Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling by Niewiadomski, Pawel, Kong, Jennifer H, Ahrends, Robert, Ma, Yan, Humke, Eric W, Khan, Sohini, Teruel, Mary N, Novitch, Bennett G, Rohatgi, Rajat

“…Gli proteins are transcriptional effectors of the Hedgehog (Hh) pathway in both normal development and cancer. We describe a program of multisite…”
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Early enforcement of cell identity by a functional component of the terminally differentiated state by Bahrami-Nejad, Zahra, Zhang, Zhi-Bo, Tholen, Stefan, Sharma, Sanjeev, Rabiee, Atefeh, Zhao, Michael L, Kraemer, Fredric B, Teruel, Mary N

“…How progenitor cells can attain a distinct differentiated cell identity is a challenging problem given the fluctuating signaling environment in which cells…”
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Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility by Stowers, Ryan S., Shcherbina, Anna, Israeli, Johnny, Gruber, Joshua J., Chang, Julie, Nam, Sungmin, Rabiee, Atefeh, Teruel, Mary N., Snyder, Michael P., Kundaje, Anshul, Chaudhuri, Ovijit

“…In breast cancer, the increased stiffness of the extracellular matrix is a key driver of malignancy. Yet little is known about the epigenomic changes that…”
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Consecutive Positive Feedback Loops Create a Bistable Switch that Controls Preadipocyte-to-Adipocyte Conversion by Park, Byung Ouk, Ahrends, Robert, Teruel, Mary N.

“…Adipogenesis, or the conversion of proliferating preadipocytes into nondividing adipocytes, is an important part of the vertebrate weight-maintenance program…”
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Molecular Competition in G1 Controls When Cells Simultaneously Commit to Terminally Differentiate and Exit the Cell Cycle by Zhao, Michael L., Rabiee, Atefeh, Kovary, Kyle M., Bahrami-Nejad, Zahra, Taylor, Brooks, Teruel, Mary N.

“…Terminal differentiation is essential for the development and maintenance of tissues in all multi-cellular organisms and is associated with permanent exit from…”
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The proteome of cholesteryl-ester-enriched versus triacylglycerol-enriched lipid droplets by Khor, Victor K, Ahrends, Robert, Lin, Ye, Shen, Wen-Jun, Adams, Christopher M, Roseman, Ann Nomoto, Cortez, Yuan, Teruel, Mary N, Azhar, Salman, Kraemer, Fredric B

“…Within cells, lipids are stored in the form of lipid droplets (LDs), consisting of a neutral lipid core, surrounded by a phospholipid monolayer and an outer…”
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Rab10, a Target of the AS160 Rab GAP, Is Required for Insulin-Stimulated Translocation of GLUT4 to the Adipocyte Plasma Membrane by Sano, Hiroyuki, Eguez, Lorena, Teruel, Mary N., Fukuda, Mitsunori, Chuang, Tuan D., Chavez, Jose A., Lienhard, Gustav E., McGraw, Timothy E.

“…GLUT4 trafficking to the plasma membrane of muscle and fat cells is regulated by insulin. An important component of insulin-regulated GLUT4 distribution is the…”
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The E3 Ubiquitin Ligase UBE3C Enhances Proteasome Processivity by Ubiquitinating Partially Proteolyzed Substrates by Chu, Bernard W., Kovary, Kyle M., Guillaume, Johan, Chen, Ling-chun, Teruel, Mary N., Wandless, Thomas J.

“…To maintain protein homeostasis, cells must balance protein synthesis with protein degradation. Accumulation of misfolded or partially degraded proteins can…”
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Comprehensive Identification of PIP3-Regulated PH Domains from C. elegans to H. sapiens by Model Prediction and Live Imaging by Park, Wei Sun, Do Heo, Won, Whalen, James H., O'Rourke, Nancy A., Bryan, Heather M., Meyer, Tobias, Teruel, Mary N.

“…Phosphoinositide 3-kinase (PI3K) and its product phosphatidylinositol(3,4,5)-trisphosphate (PIP3) control cell growth, migration, and other processes by…”
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Expression variation and covariation impair analog and enable binary signaling control by Kovary, Kyle M, Taylor, Brooks, Zhao, Michael L, Teruel, Mary N

“…Due to noise in the synthesis and degradation of proteins, the concentrations of individual vertebrate signaling proteins were estimated to vary with a…”
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Parallel adaptive feedback enhances reliability of the Ca2+signaling system by Abell, Ellen, Ahrends, Robert, Bandara, Samuel, Park, Byung Ouk, Teruel, Mary N.

“…Despite large cell-to-cell variations in the concentrations of individual signaling proteins, cells transmit signals correctly. This phenomenon raises the…”
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Neuropilins are positive regulators of Hedgehog signal transduction by Hillman, R Tyler, Feng, Brian Y, Ni, Jun, Woo, Wei-Meng, Milenkovic, Ljiljana, Hayden Gephart, Melanie G, Teruel, Mary N, Oro, Anthony E, Chen, James K, Scott, Matthew P

“…The Hedgehog (Hh) pathway is essential for vertebrate embryogenesis, and excessive Hh target gene activation can cause cancer in humans. Here we show that…”
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Using SRM-MS to quantify nuclear protein abundance differences between adipose tissue depots of insulin-resistant mice by Ota, Asuka, Kovary, Kyle M., Wu, Olivia H., Ahrends, Robert, Shen, Wen-Jun, Costa, Maria J., Feldman, Brian J., Kraemer, Fredric B., Teruel, Mary N.

“…Insulin resistance (IR) underlies metabolic disease. Visceral, but not subcutaneous, white adipose tissue (WAT) has been linked to the development of IR,…”
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Cortisol and cardiometabolic disease: a target for advancing health equity by Ortiz, Robin, Kluwe, Bjorn, Lazarus, Sophie, Teruel, Mary N., Joseph, Joshua J.

“…Stress, in both intrinsic psychosocial and extrinsic physical environmental forms, can impact the development of, and outcomes in, cardiovascular disease (CVD)…”
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The circadian clock mediates daily bursts of cell differentiation by periodically restricting cell-differentiation commitment by Zhang, Zhi-Bo, Sinha, Joydeb, Bahrami-Nejad, Zahra, Teruel, Mary N

“…Most mammalian cells have an intrinsic circadian clock that coordinates metabolic activity with the daily rest and wake cycle. The circadian clock is known to…”
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Green Fluorescent Protein (GFP)-Tagged Cysteine-Rich Domains from Protein Kinase C as Fluorescent Indicators for Diacylglycerol Signaling in Living Cells by Oancea, Elena, Teruel, Mary N., Andrew F. G. Quest, Meyer, Tobias

“…Cysteine-rich domains (Cys-domains) are ∼50-amino acid-long protein domains that complex two zinc ions and include a consensus sequence with six cysteine and…”
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A Transcriptional Circuit Filters Oscillating Circadian Hormonal Inputs to Regulate Fat Cell Differentiation by Bahrami-Nejad, Zahra, Zhao, Michael L., Tholen, Stefan, Hunerdosse, Devon, Tkach, Karen E., van Schie, Sabine, Chung, Mingyu, Teruel, Mary N.

“…Glucocorticoid and other adipogenic hormones are secreted in mammals in circadian oscillations. Loss of this circadian oscillation pattern correlates with…”
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Controlling low rates of cell differentiation through noise and ultrahigh feedback by Ahrends, Robert, Ota, Asuka, Kovary, Kyle M., Kudo, Takamasa, Park, Byung Ouk, Teruel, Mary N.

“…Mammalian tissue size is maintained by slow replacement of de-differentiating and dying cells. For adipocytes, key regulators of glucose and lipid metabolism,…”
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Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide by Shi, Zhen, Fujii, Kotaro, Kovary, Kyle M., Genuth, Naomi R., Röst, Hannes L., Teruel, Mary N., Barna, Maria

“…Emerging studies have linked the ribosome to more selective control of gene regulation. However, an outstanding question is whether ribosome heterogeneity at…”
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Flattening of circadian glucocorticoid oscillations drives acute hyperinsulinemia and adipocyte hypertrophy by Tholen, Stefan, Patel, Roma, Agas, Agnieszka, Kovary, Kyle M, Rabiee, Atefeh, Nicholls, Hayley T, Bielczyk-Maczyńska, Ewa, Yang, Wenting, Kraemer, Fredric B, Teruel, Mary N

“…Disruption of circadian glucocorticoid oscillations in Cushing's disease and chronic stress results in obesity and adipocyte hypertrophy, which is believed to…”
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