Search Results - "Mary Lynne Hedley"

Formulations containing poly(lactide-co-glycolide) and plasmid DNA expression vectors by Hedley, Mary Lynne

“…DNA expression vectors have the potential to be useful therapeutics for a wide variety of applications. However, development has been hindered by the lack of…”
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Phase 3 trial results for rolapitant, a novel NK-1 receptor antagonist, in the prevention of chemotherapy-induced nausea and vomiting (CINV) in subjects receiving highly emetogenic chemotherapy (HEC) by Rapoport, Bernardo Leon, Poma, Allen, Hedley, Mary Lynne, Martell, Robert E., Navari, Rudolph M.

“…Abstract only…”
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Phase 1 positron emission tomography (PET) study of the receptor occupancy of rolapitant, a novel NK-1 receptor antagonist by Poma, Allen, Christensen, Jennifer, Davis, Jennifer, Kansra, Vikram, Martell, Robert E., Hedley, Mary Lynne

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Efficacy and safety of rolapitant, a novel NK-1 receptor antagonist, for the prevention of chemotherapy-induced nausea and vomiting in subjects receiving highly emetogenic chemotherapy by Fein, Luis Enrique, Poma, Allen, Hedley, Mary Lynne

“…Abstract only 9077 Background: Management of chemotherapy-induced nausea and vomiting (CINV) improves quality of life and increases the likelihood that…”
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ZYC101a for Treatment of High-Grade Cervical Intraepithelial Neoplasia: A Randomized Controlled Trial by Garcia, Francisco, Petry, Karl Ulrich, Muderspach, Laila, Gold, Michael A, Braly, Patricia, Crum, Christopher P, Magill, Marianne, Silverman, Michael, Urban, Robert G, Hedley, Mary Lynne, Beach, Kathleen J

“…OBJECTIVE:The objective of this study was to assess the safety and efficacy of a novel therapeutic, ZYC101a, for the treatment of women with histologically…”
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Phase 3 trial results for rolapitant, a novel NK-1 receptor antagonist, in the prevention of chemotherapy-induced nausea and vomiting (CINV) in subjects receiving moderately emetogenic chemotherapy (MEC) by Schnadig, Ian D., Modiano, Manuel R., Poma, Allen, Hedley, Mary Lynne, Martell, Robert E., Schwartzberg, Lee Steven

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Immunization with a poly (lactide co-glycolide) encapsulated plasmid DNA expressing antigenic regions of HPV 16 and 18 results in an increase in the precursor frequency of T cells that respond to epitopes from HPV 16, 18, 6 and 11 by Matijevic, Mark, Hedley, Mary Lynne, Urban, Robert G., Chicz, Roman M., Lajoie, Christa, Luby, Thomas M.

“…► Immunization with amolimogene induces T cells specific to HPV in HSIL subjects. ► Amolimogene expresses T cell epitopes from E6/E7 proteins of HPV types 16…”
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1109. Targeting CYP1B1 with a Therapeutic Cancer Vaccine: Results of Preclinical and Clinical Studies by Lynne Hedley, Mary

“…Injection of microparticle encapsulated DNA has been shown to elicit immune responses to the plasmid-encoded antigens, and the use of this technology in a…”
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Consecutive low doses of cyclophosphamide preferentially target T regs and potentiate T cell responses induced by DNA PLG microparticle immunization by Barbon, Christine M., Yang, Min, Wands, Gregory D., Ramesh, Radha, Slusher, Barbara S., Hedley, Mary Lynne, Luby, Thomas M.

“…Cyclophosphamide in combination with immunotherapeutic approaches preferentially impinges on T reg activity and allows for robust generation of T cell…”
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Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: A Phase I study of ZYC101 by KLENCKE, Barbara, MATIJEVIC, Mark, JAY, Naomi, DA COSTA, Maria, PALEFSKY, Joel M, URBAN, Robert G, LATHEY, Janet L, HEDLEY, Mary Lynne, BERRY, Michael, THATCHER, Joe, WEINBERG, Vivian, WILSON, Jennifer, DARRAGH, Teresa

“…High-grade dysplasia induced by high-risk types of human papillomavirus (HPV) precedes invasive cancer in anal squamous epithelium just as it does in the…”
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Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responses by Hedley, Mary Lynne, Curley, Joanne, Urban, Robert

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In vivo electroporation enhances the potency of poly-lactide co-glycolide (PLG) plasmid DNA immunization by Barbon, Christine M, Baker, Lisa, Lajoie, Christa, Ramstedt, Urban, Hedley, Mary Lynne, Luby, Thomas M

“…Abstract Immunization with plasmid DNA that has been encapsulated in poly lactide-co-glycolide (PLG) microparticles targets the plasmid DNA to antigen…”
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Immunotherapy of human cervical high-grade cervical intraepithelial neoplasia with microparticle-delivered human papillomavirus 16 E7 plasmid DNA by Sheets, Ellen E., Urban, Robert G., Crum, Christopher P., Hedley, Mary Lynne, Politch, Joseph A., Gold, Michael A., Muderspach, Laila I., Cole, Geoffrey A., Crowley-Nowick, Peggy A.

“…Objective: The purpose of this study was to evaluate the safety of the administration of a bacterial expression plasmid encoding a 13 amino acid sequence that…”
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Consecutive low doses of cyclophosphamide preferentially target Tregs and potentiate T cell responses induced by DNA PLG microparticle immunization by Barbon, Christine M, Yang, Min, Wands, Gregory D, Ramesh, Radha, Slusher, Barbara S, Hedley, Mary Lynne, Luby, Thomas M

“…Cyclophosphamide in combination with immunotherapeutic approaches preferentially impinges on T(reg) activity and allows for robust generation of T cell…”
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Gene delivery with in-situ crosslinking polymer networks generates long-term systemic protein expression by Roy, Krishnendu, Wang, Daqing, Hedley, Mary Lynne, Barman, Shikha P

“…Two polyethylene oxide-based delivery systems comprised of reacting PEG polymers were designed for the delivery of DNA expression vectors. The polymers are…”
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Gene therapy of chronic inflammatory disease: Challenges of Turning Nucleic Acids into Therapeutics by HEDLEY, Mary Lynne

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The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2 by Amrein, H, Hedley, M L, Maniatis, T

“…We have investigated the function of different structural domains of the Drosophila splicing regulator Transformer 2 (Tra2). We find that the ribonucleoprotein…”
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Repeated immunization with plasmid DNA formulated in poly(lactide-co-glycolide) microparticles is well tolerated and stimulates durable T cell responses to the tumor-associated antigen cytochrome P450 1B1 by Luby, Thomas M, Cole, Geoffrey, Baker, Lisa, Kornher, J.Steven, Ramstedt, Urban, Hedley, Mary Lynne

“…Injection of microparticle-encapsulated DNA elicits immune responses to plasmid-encoded antigens in mice and humans. Cytochrome P450 CYP1B1 (CYP1B1) is a…”
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Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro by Hedley, M L, Maniatis, T

“…Somatic sex determination in Drosophila involves a hierarchy of regulated alternative pre-mRNA processing. Female-specific splicing and/or polyadenylation of…”
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Gene therapy of chronic inflammatory disease by Hedley, Mary Lynne

“…Immune mediated inflammation that culminates in severe tissue necrosis is the hallmark of diseases that result from an inappropriate response to antigen. The…”
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