Search Results - "Marx, Samira"

Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2 by Ostendorf, Thomas, Zillinger, Thomas, Andryka, Katarzyna, Schlee-Guimaraes, Thais Marina, Schmitz, Saskia, Marx, Samira, Bayrak, Kübra, Linke, Rebecca, Salgert, Sarah, Wegner, Julia, Grasser, Tatjana, Bauersachs, Sonja, Soltesz, Leon, Hübner, Marc P., Nastaly, Maximilian, Coch, Christoph, Kettwig, Matthias, Roehl, Ingo, Henneke, Marco, Hoerauf, Achim, Barchet, Winfried, Gärtner, Jutta, Schlee, Martin, Hartmann, Gunther, Bartok, Eva

“…Human toll-like receptor 8 (TLR8) activation induces a potent T helper-1 (Th1) cell response critical for defense against intracellular pathogens, including…”
Get full text

RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection by Marx, Samira, Kümmerer, Beate M., Grützner, Christian, Kato, Hiroki, Schlee, Martin, Renn, Marcel, Bartok, Eva, Hartmann, Gunther

“…The SARS-CoV-2 pandemic has underscored the need for rapidly usable prophylactic and antiviral treatments against emerging viruses. The targeted stimulation of…”
Get full text

RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation by Engel, Christina, Brügmann, Grethe, Lambing, Silke, Mühlenbeck, Larissa H, Marx, Samira, Hagen, Christian, Horváth, Dorottya, Goldeck, Marion, Ludwig, Janos, Herzner, Anna-Maria, Drijfhout, Jan W, Wenzel, Daniela, Coch, Christoph, Tüting, Thomas, Schlee, Martin, Hornung, Veit, Hartmann, Gunther, Van den Boorn, Jasper G

“…A hypoxic tumor microenvironment is linked to poor prognosis. It promotes tumor cell dedifferentiation and metastasis and desensitizes tumor cells to type-I…”
Get more information

Immune sensing of synthetic, bacterial and protozoan RNA by TLR8 requires coordinated processing of RNA substrates by RNaseT2 and RNase2 by Bartok, Eva Sarah, Ostendorf, Thomas, Zillinger, Thomas, Andryka, Katarzyna, Guimaraes, Thais Marina, Schmitz, Saskia, Marx, Samira, Bayrak, Kübra, Linke, Rebecca, Salgert, Sarah, Grasser, Tatjana, Baersachs, Sonja, Hübner, Marc, Soltesz, Leon, Kettwig, Matthias, Nastaly, Maximilian, Roehl, Ingo, Henneke, Marco, Barchet, Winfried, Gärtner, Jutta, Schlee, Martin, Hartmann, Gunther

“…Abstract Human TLR8 is an essential sensor of bacterial RNA which induces proinflammatory and Th1 cytokines. Crystallography revealed that TLR8 binds both…”
Get full text

Rescue of T-cell function during persistent pulmonary adenoviral infection by Toll-like receptor 9 activation by Holland, Tristan, Wohlleber, Dirk, Marx, Samira, Kreutzberg, Thomas, Vento-Asturias, Salvador, Schmitt-Mbamunyo, Christine, Welz, Meike, Janas, Marianne, Komander, Karl, Eickhoff, Sarah, Brewitz, Anna, Hasenberg, Mike, Männ, Linda, Gunzer, Matthias, Wilhelm, Christoph, Kastenmüller, Wolfgang, Knolle, Percy, Abdullah, Zeinab, Kurts, Christian, Garbi, Natalio

“…To establish a novel murine model of pulmonary adenoviral persistence, we performed intratracheal inoculation with AdLGO, a recombinant adenovirus coding for…”
Get full text