Search Results - "Maruyama, Kazuo"

Intracellular targeting delivery of liposomal drugs to solid tumors based on EPR effects by Maruyama, Kazuo

“…The success of an effective drug delivery system using liposomes for solid tumor targeting based on EPR effects is highly dependent on both size ranging from…”
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Lipid-based microbubbles and ultrasound for therapeutic application by Omata, Daiki, Unga, Johan, Suzuki, Ryo, Maruyama, Kazuo

“…Microbubbles with diagnostic ultrasound have had a long history of use in the medical field. In recent years, the therapeutic application of the combination of…”
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Effects of encapsulated gas on stability of lipid-based microbubbles and ultrasound-triggered drug delivery by Omata, Daiki, Maruyama, Tamotsu, Unga, Johan, Hagiwara, Fumiko, Munakata, Lisa, Kageyama, Saori, Shima, Tadamitsu, Suzuki, Yuno, Maruyama, Kazuo, Suzuki, Ryo

“…The combination of Ultrasound (US) and US contrast agent (microbubbles, MBs), which is gas stabilized by a shell such as phospholipids or proteins, has…”
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Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery by Omata, Daiki, Munakata, Lisa, Maruyama, Kazuo, Suzuki, Ryo

“…Ultrasound and microbubbles, an ultrasound contrast agent, have recently increased attention to developing novel drug delivery systems. Ultrasound exposure can…”
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Preparation of Angiopep-2 Peptide-Modified Bubble Liposomes for Delivery to the Brain by Endo-Takahashi, Yoko, Ooaku, Kotomi, Ishida, Kazuma, Suzuki, Ryo, Maruyama, Kazuo, Negishi, Yoichi

“…In the development of therapeutic approaches for central nervous system diseases, a significant obstacle is efficient drug delivery across the blood–brain…”
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The Application of the in-Situ Hyperthermia Emission from Acoustic Nanodroplets for Theranostic Dual-Imaging and Antitumor Modalities by Abdalkader, Rodi, Unga, Johan, Maruyama, Kazuo, Yamashita, Fumiyoshi, Hashida, Mitsuru

“…In this study, we have developed a theranostic nanocarrier that can emit heat upon the exposure to ultrasound (US) irradiation as well as the generation of a…”
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Evaluation of the Theranostic Potential of Perfluorohexane-Based Acoustic Nanodroplets by Abdalkader, Rodi, Unga, Johan, Yamashita, Fumiyoshi, Maruyama, Kazuo, Hashida, Mitsuru

“…In this study, we have prepared perfluorohexane (PFH)-based acoustic nanodroplets (PFH-NDs) and evaluated their theranostic characteristics. Nile Red (NR) was…”
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Enhanced antitumor activity of combined lipid bubble ultrasound and anticancer drugs in gynecological cervical cancers by Yamaguchi, Kohei, Matsumoto, Yoko, Suzuki, Ryo, Nishida, Haruka, Omata, Daiki, Inaba, Hirofumi, Kukita, Asako, Tanikawa, Michihiro, Sone, Kenbun, Oda, Katsutoshi, Osuga, Yutaka, Maruyama, Kazuo, Fujii, Tomoyuki

“…Chemotherapy plays an important role in the treatment of patients with gynecological cancers. Delivering anticancer drugs effectively to tumor cells with just…”
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Multifunctional liposomes having target specificity, temperature-triggered release, and near-infrared fluorescence imaging for tumor-specific chemotherapy by Kono, Kenji, Takashima, Munenobu, Yuba, Eiji, Harada, Atsushi, Hiramatsu, Yoshie, Kitagawa, Hiroyuki, Otani, Takayuki, Maruyama, Kazuo, Aoshima, Sadahito

“…We designed functional liposomes with target specificity, temperature-triggered drug release, and near-infrared fluorescence imaging. We prepared the liposomes…”
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Development of Dendritic Cell-Based Immunotherapy Targeting Tumor Blood Vessels in a Mouse Model of Lung Metastasis by Nomura, Tetsuya, Yamakawa, Makie, Shimaoka, Takuto, Hirai, Takamasa, Koizumi, Naoya, Maruyama, Kazuo, Utoguchi, Naoki

“…Tumor blood vessels supply cancer tissues with oxygen and nutrients, and it was therefore believed that inhibition of angiogenesis would induce tumor…”
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Epidermal growth factor receptor-targeted sonoporation with microbubbles enhances therapeutic efficacy in a squamous cell carcinoma model by Hirabayashi, Fumika, Iwanaga, Kenjiro, Okinaga, Toshinori, Takahashi, Osamu, Ariyoshi, Wataru, Suzuki, Ryo, Sugii, Mutsumi, Maruyama, Kazuo, Tominaga, Kazuhiro, Nishihara, Tatsuji

“…Sonoporation is a drug and gene delivery system using ultrasonication that allows the intracellular delivery of foreign molecules that cannot enter cells under…”
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Ultrasound and microbubble-mediated drug delivery and immunotherapy by Omata, Daiki, Munakata, Lisa, Maruyama, Kazuo, Suzuki, Ryo

“…Ultrasound induces the oscillation and collapse of microbubbles such as those of an ultrasound contrast agent, where these behaviors generate mechanical and…”
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The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension by Morikawa, Masato, Mitani, Yoshihide, Holmborn, Katarina, Kato, Taichi, Koinuma, Daizo, Maruyama, Junko, Vasilaki, Eleftheria, Sawada, Hirofumi, Kobayashi, Mai, Ozawa, Takayuki, Morishita, Yasuyuki, Bessho, Yasumasa, Maeda, Shingo, Ledin, Johan, Aburatani, Hiroyuki, Kageyama, Ryoichiro, Maruyama, Kazuo, Heldin, Carl-Henrik, Miyazono, Kohei

“…Dysregulated bone morphogenetic protein (BMP) signaling in endothelial cells (ECs) is implicated in vascular diseases such as pulmonary arterial hypertension…”
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Brain Delivery of Cisplatin Using Microbubbles in Combination with Ultrasound as an Effective Therapy for Glioblastoma by Hagiwara, Fumiko, Omata, Daiki, Munakata, Lisa, Kageyama, Saori, Maruyama, Kazuo, Kudo, Nobuki, Suzuki, Ryo

“…Glioblastoma is a highly invasive and fatal disease. Temozolomide, a blood–brain barrier (BBB)-penetrant therapeutic agent currently used for glioblastoma,…”
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Scale-up production, characterization and toxicity of a freeze-dried lipid-stabilized microbubble formulation for ultrasound imaging and therapy by Unga, Johan, Kageyama, Saori, Suzuki, Ryo, Omata, Daiki, Maruyama, Kazuo

“…Microbubble formulations have a long history for enhancement of ultrasound (US) imaging and recently also for therapeutic applications. Previously, a series of…”
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Evaluation of the potential of doxorubicin loaded microbubbles as a theranostic modality using a murine tumor model by Abdalkader, Rodi, Kawakami, Shigeru, Unga, Johan, Suzuki, Ryo, Maruyama, Kazuo, Yamashita, Fumiyoshi, Hashida, Mitsuru

“…[Display omitted] In this study, a novel phospholipid-based microbubble formulation containing doxorubicin and perfluoropropane gas (DLMB) was developed. The…”
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Effective anti-tumor activity of oxaliplatin encapsulated in transferrin–PEG-liposome by Suzuki, Ryo, Takizawa, Tomoko, Kuwata, Yasuhiro, Mutoh, Mahito, Ishiguro, Nobuyuki, Utoguchi, Naoki, Shinohara, Atsuko, Eriguchi, Masazumi, Yanagie, Hironobu, Maruyama, Kazuo

“…Oxaliplatin ( trans- l-diaminocyclohexane oxalatoplatinum, l-OHP) is a novel cisplatin derivative that can improve the side effects of cisplatin such as…”
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Development of Ultrasound Theranostics for Cancer by Suzuki, Ryo, Maruyama, Kazuo

“…Theranostics is a term used to describe the combination of diagnostic and therapeutic functions in a single agent. Ultrasound, for example, is a good tool for…”
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Lipid bubbles combined with low-intensity ultrasound enhance the intratumoral accumulation and antitumor effect of pegylated liposomal doxorubicin in vivo by Yokoe, Inoru, Omata, Daiki, Unga, Johan, Suzuki, Ryo, Maruyama, Kazuo, Okamoto, Yoshiharu, Osaki, Tomohiro

“…Pegylated liposomal doxorubicin (PLD) is a representative nanomedicine that has improved tumor selectivity and safety profile. However, the therapeutic…”
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Experimental study of ultrasound retention of bubble-surrounded cells under various conditions of acoustic field and flow velocity by Chikaarashi, Takumi, Watanabe, Shunya, Miyamoto, Yoshitaka, Omata, Daiki, Maruyama, Kazuo, Suzuki, Ryo, Masuda, Kohji

“…Abstract We confirmed that bubble-surrounded cells (BSCs) contained in flow were retained on the walls of an artificial blood vessel by forming an acoustic…”
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