Search Results - "Maruyama, Itaru"

Effects of the combination of vibegron and imidafenacin on bladder function in urethane-anesthetized rats by Yamazaki, Takanobu, Maruyama, Itaru

“…The combination of a β3-adrenoceptor agonist and an antimuscarinic agent was revealed to be more effective than monotherapy for patients with overactive…”
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Vibegron shows high selectivity and potent agonist activity for β3-adrenoceptors, irrespective of receptor density by Yamamoto, Shota, Kusabuka, Hotaka, Matsuzawa, Akane, Maruyama, Itaru, Yamazaki, Takanobu

“…β3-Adrenoceptor (AR) agonists are used to treat patients with an overactive bladder (OAB). Clinical proof-of-concept data have been obtained for the β3-AR…”
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Effects of ritobegron (KUC-7483), a novel selective β3-adrenoceptor agonist, on bladder function in cynomolgus monkey by Maruyama, Itaru, Tatemichi, Satoshi, Goi, Yoshiaki, Maruyama, Kazuyasu, Hoyano, Yuji, Yamazaki, Yoshinobu, Kusama, Hiroshi

“…We evaluated the pharmacological profile of ritobegron [KUC-7483; (-)-ethyl…”
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Bladder selectivity of the novel β3-agonist ritobegron (KUC-7483) explored by in vitro and in vivo studies in the rat by Maruyama, Itaru, Goi, Yoshiaki, Tatemichi, Satoshi, Maruyama, Kazuyasu, Hoyano, Yuji, Yamazaki, Yoshinobu, Kusama, Hiroshi

“…We performed in vitro and in vivo experiments to evaluate the pharmacological profile of ritobegron and its effects on the bladder in rats. β 3 -AR selectivity…”
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Effects of ritobegron (KUC-7483), a novel β3-adrenoceptor agonist, on both rat bladder function following partial bladder outlet obstruction and on rat salivary secretion: a comparison with the effects of tolterodine by Maruyama, Itaru, Yonekubo, Saori, Tatemichi, Satoshi, Maruyama, Kazuyasu, Hoyano, Yuji, Yamazaki, Yoshinobu, Kusama, Hiroshi

“…The objective of this study was to investigate the effects of the β3-adrenoceptor (AR) agonist ritobegron on rat bladder function following partial bladder…”
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Uroselectivity in male dogs of silodosin (KMD-3213), a novel drug for the obstructive component of benign prostatic hyperplasia by Tatemichi, Satoshi, Tomiyama, Yoshitaka, Maruyama, Itaru, Kobayashi, Shinya, Kobayashi, Kumi, Maezawa, Ayaka, Kobayashi, Mamoru, Yamazaki, Yoshinobu, Shibata, Nobuo

“…Aims Our main aim was to compare the prostatic selectivity of silodosin with that of other α1‐adrenoceptor (AR) antagonists. Methods We examined…”
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Vibegron shows high selectivity and potent agonist activity for [beta]3-adrenoceptors, irrespective of receptor density by Yamamoto, Shota, Kusabuka, Hotaka, Matsuzawa, Akane, Maruyama, Itaru, Yamazaki, Takanobu

“…[beta]3-Adrenoceptor (AR) agonists are used to treat patients with an overactive bladder (OAB). Clinical proof-of-concept data have been obtained for the…”
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Effects of mitiglinide and sulfonylureas in isolated canine coronary arteries and perfused rat hearts by Maruyama, Itaru, Tomiyama, Yoshitaka, Maruyama, Kazuyasu, Ojima, Kazuma, Kobayashi, Kumi, Kobayashi, Mamoru, Yamazaki, Yoshinobu, Kojima, Masami, Shibata, Nobuo

“…Our aim was to compare the cardiovascular effects of mitiglinide ((+)-monocalcium bis[( 2S,3a,7a- cis)-α-benzylhexahydro-γ-oxo-2-isoindolinebutyrate]…”
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Vibegron inhibits enhanced spontaneous contractions induced by anoxia/reoxygenation in isolated whole bladder from rats by Ikeda, Makoto, Nakada, Akihiro, Abukawa, Hayato, Yamazaki, Takanobu, Maruyama, Itaru

“…It has been recently proposed that repeated bladder ischemia/reperfusion induced by chronic pelvic ischemia may lead to detrusor overactivity, followed by…”
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Effects of vibegron, a novel β3-adrenoceptor agonist, and its combination with imidafenacin or silodosin in a rat with partial bladder outlet obstruction by Maruyama, Itaru, Yamamoto, Shota, Tsuchioka, Kumi, Yamazaki, Takanobu

“…Urgency is regarded as a core symptom of overactive bladder (OAB) and may correspond to detrusor overactivity (DO). One of the causes of OAB in men is bladder…”
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Effects of Silodosin (KMD-3213) on Phenylephrine-induced Increase in Intraurethral Pressure and Blood Pressure in Rats—Study of the Selectivity for Lower Urinary Tract by TATEMICHI, Satoshi, KOBAYASHI, Kumi, MARUYAMA, Itaru, KOBAYASHI, Mamoru, YAMAZAKI, Yoshinobu, SHIBATA, Nobuo

“…The effects of silodosin, an α1A-adrenoceptor (AR) antagonist, and of other α1-AR antagonists on the phenylephrine (PE)-induced increase in intraurethral…”
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Duration of Action of Silodosin (KMD-3213) against Phenylephrine-induced Increase in Intraurethral Pressure in Rats by KOBAYASHI, Mamoru, TATEMICHI, Satoshi, KOBAYASHI, Kumi, IMAMURA, Takahiro, MARUYAMA, Itaru, YAMAZAKI, Yoshinobu, SHIBATA, Nobuo

“…The duration of action of Silodosin (KMD-3213) against the phenylephrine-induced increase in intraurethral pressure in urethane-anesthetized rats was compared…”
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Effects of vibegron, a novel β 3 -adrenoceptor agonist, and its combination with imidafenacin or silodosin in a rat with partial bladder outlet obstruction by Maruyama, Itaru, Yamamoto, Shota, Tsuchioka, Kumi, Yamazaki, Takanobu

“…Urgency is regarded as a core symptom of overactive bladder (OAB) and may correspond to detrusor overactivity (DO). One of the causes of OAB in men is bladder…”
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Silodosin, an α(1A)-Adrenoceptor Antagonist, May Ameliorate Ischemia-Induced Bladder Denervation and Detrusor Dysfunction by Improving Bladder Blood Flow by Goi, Yoshiaki, Tomiyama, Yoshitaka, Maruyama, Itaru, Tatemichi, Satoshi, Maruyama, Kazuyasu, Kobayashi, Mamoru, Nomiya, Masanori, Yamaguchi, Osamu

“…This study was performed to investigate the detailed mechanism underlying the effects of the selective α(1A)-adrenoceptor antagonist, silodosin, on bladder…”
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ラットのフェニレフリン誘発尿道内圧上昇及び血圧に対するシロドシン(KMD-3213)の作用 : 下部尿路選択性の検討(<特集>シロドシン) by 立道, 聡, 小林, 久美, 丸山, 格, 小林, 護, 山崎, 芳伸, 柴田, 信男

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ラットのフェニレフリン誘発尿道内圧上昇に対するシロドシン(KMD-3213)の作用持続性(<特集>シロドシン) by 小林, 護, 立道, 聡, 小林, 久美, 今村, 卓広, 丸山, 格, 山崎, 芳伸, 柴田, 信男

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Effects of Silodosin (KMD-3213) on Phenylephrine-induced Increase in Intraurethral Pressure and Blood Pressure in Rats : Study of the Selectivity for Lower Urinary Tract by TATEMICHI, Satoshi, KOBAYASHI, Kumi, MARUYAMA, Itaru, KOBAYASHI, Mamoru, YAMAZAKI, Yoshinobu, SHIBATA, Nobuo

“…The effects of silodosin, an α_ -adrenoceptor (AR) antagonist, and of other α_1-AR antagonists on the phenylephrine (PE)-induced increase in intraurethral…”
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Duration of Action of Silodosin (KMD-3213) against Phenylephrine-induced Increase in Intraurethral Pressure in Rats by KOBAYASHI, Mamoru, TATEMICHI, Satoshi, KOBAYASHI, Kumi, IMAMURA, Takahiro, MARUYAMA, Itaru, YAMAZAKI, Yoshinobu, SHIBATA, Nobuo

“…The duration of action of Silodosin (KMD-3213) against the phenylephrine-induced increase in intraurethral pressure in urethane-anesthetized rats was compared…”
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Effects of ritobegron (KUC-7483), a novel β3-adrenoceptor agonist, on both rat bladder function following partial bladder outlet obstruction and on rat salivary secretion: a comparison with the effects of tolterodine by Maruyama, Itaru, Yonekubo, Saori, Tatemichi, Satoshi, Maruyama, Kazuyasu, Hoyano, Yuji, Yamazaki, Yoshinobu, Kusama, Hiroshi

“…The objective of this study was to investigate the effects of the β3-adrenoceptor (AR) agonist ritobegron on rat bladder function following partial bladder…”
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Are glycine receptors involved in micturition reflex ? by Itaru Maruyama, Yuichi Okabe, Tetsuya Shirasaki, Hitoshi Ishibashi, Kazuo Takahama

“…Much remains open about central mechanisms of micturition reflex, although it is regulated by the micturition centers in the brain stem and spinal cord. In…”
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