Search Results - "Marutle, A"

Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue by RUIQING NI, GILLBERG, Per-Göran, BERGFORS, Assar, MARUTLE, Amelia, NORDBERG, Agneta

“…Imaging fibrillar amyloid-β deposition in the human brain in vivo by positron emission tomography has improved our understanding of the time course of…”
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Comparison of Aβ levels in the brain of familial and sporadic Alzheimer's disease by Hellström-Lindahl, E., Viitanen, M., Marutle, A.

“…Mutations in presenilin (PS) and amyloid precursor protein (APP) genes are a predominant cause for early-onset familial Alzheimer disease (AD). Although these…”
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P.1.002 Drug interaction between fibrillar amyloid β and alpha7 nicotinic receptor in Alzheimer brain by Ni, R, Marutle, A, Nordberg, A

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Practical issues in stem cell therapy for Alzheimer's disease by Sugaya, K, Kwak, Y D, Ohmitsu, O, Marutle, A, Greig, N H, Choumrina, E

“…We have demonstrated that aged animals show significant improvements in cognitive function and neurogenesis after brain transplantation of human neural stem…”
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P.1.022 Amyloid aggregation is critical for the interaction with neuronal nicotinic acetylcholine receptors (nAChRs) – implications for neuroprotection in Alzheimer's disease by Lilja, A.M, Porras, O, Storelli, E, Nordberg, A, Marutle, A

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S.04.05 Interactions of oligomeric and fibrillar b-amyloid with a7 neuronal nicotinic receptors and synaptic targets in Alzheimer's disease by Lilja, A, Porras, O, Storelli, E, Nordberg, A, Marutle, A

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Stem cell strategies for Alzheimer's disease therapy by Sugaya, K, Alvarez, A, Marutle, A, Kwak, Y D, Choumkina, E

“…We have found much evidence that the brain is capable of regenerating neurons after maturation. In our previous study, human neural stem cells (HNSCs)…”
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Neuronal nicotinic receptor deficits in Alzheimer patients with the Swedish amyloid precursor protein 670/671 mutation by MARUTLE, A, WARPMAN, U, BOGDANOVIC, N, LANNFELT, L, NORDBERG, A

“…The influence of beta-amyloid on cholinergic neurotransmission was studied by measuring alterations in nicotinic acetylcholine receptors (nAChRs) in autopsy…”
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Modulation of α7 nicotinic acetylcholine receptor and fibrillar amyloid-β interactions in Alzheimer's disease brain by Ni, Ruiqing, Marutle, Amelia, Nordberg, Agneta

“…The nicotinic receptors (nAChRs), which play a critical role in cognitive function, are impaired early in the course of Alzheimer's disease (AD). We have…”
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Glial Asthenia and Functional Paralysis: A New Perspective on Neurodegeneration and Alzheimer’s Disease by Verkhratsky, Alexei, Marutle, Amelia, Rodríguez-Arellano, J. J., Nordberg, Agneta

“…Neuroglia are represented by several population of cells heterogeneous in structure and function that provide for the homeostasis of the brain and the spinal…”
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Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity by Bao, Fuxiang, Wicklund, Linn, Lacor, Pascale N, Klein, William L, Nordberg, Agneta, Marutle, Amelia

“…Abstract In this study, we examined the relationship between various β-amyloid (Aβ) oligomer assemblies in autopsy brain with the levels of fibrillar Aβ and…”
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Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease by NADIR, Ahmadul, MARUTLE, Amelia, GONZALEZ, Daniel, SCHÖLL, Michael, ALMKVIST, Ove, MOUSAVI, Malahat, MUSTAFIZ, Tamanna, DARREH-SHORI, Taher, NENNESMO, Inger, NORDBERG, Agneta

“…The accumulation of β-amyloid in the brain is an early event in Alzheimer's disease. This study presents the first patient with Alzheimer's disease who…”
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Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation by Shafaati, Marjan, Marutle, Amelia, Pettersson, Hanna, Lövgren-Sandblom, Anita, Olin, Maria, Pikuleva, Irina, Winblad, Bengt, Nordberg, Agneta, Björkhem, Ingemar

“…There is a significant flux of the neurotoxic oxysterol 27-hydroxycholesterol (27OHC) from the circulation across the blood-brain barrier. Because there is a…”
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Fibrillar β‐amyloid 1‐42 alters cytokine secretion, cholinergic signalling and neuronal differentiation by Malmsten, Linn, Vijayaraghavan, Swetha, Hovatta, Outi, Marutle, Amelia, Darreh‐Shori, Taher

“…Adult neurogenesis is impaired by inflammatory processes, which are linked to altered cholinergic signalling and cognitive decline in Alzheimer's disease. In…”
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Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell‐derived neurons by Nilbratt, Mats, Porras, Omar, Marutle, Amelia, Hovatta, Outi, Nordberg, Agneta

“…Cholinergic neurotransmission is essential for many important functions in the brain, including cognitive mechanisms. Here we demonstrate that human embryonic…”
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Functional interactions of fibrillar and oligomeric amyloid-β with alpha7 nicotinic receptors in Alzheimer's disease by Lilja, Anna M, Porras, Omar, Storelli, Elisa, Nordberg, Agneta, Marutle, Amelia

“…Amyloid-β (Aβ) peptides in the brain of patients with Alzheimer's disease (AD) assemble into various aggregation forms that differ in size, structure, and…”
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Visualization of regional tau deposits using (3)H-THK5117 in Alzheimer brain tissue by Lemoine, Laetitia, Saint-Aubert, Laure, Marutle, Amelia, Antoni, Gunnar, Eriksson, Jonas P, Ghetti, Bernardino, Okamura, Nobuyuki, Nennesmo, Inger, Gillberg, Per-Göran, Nordberg, Agneta

“… The accumulation of neurofibrillary tangles, composed of aggregated hyperphosphorylated tau protein, starts spreading early in specific regions in the course…”
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Neurotrophic and neuroprotective actions of (-)- and (+)-phenserine, candidate drugs for Alzheimer's disease by Lilja, Anna M, Luo, Yu, Yu, Qian-sheng, Röjdner, Jennie, Li, Yazhou, Marini, Ann M, Marutle, Amelia, Nordberg, Agneta, Greig, Nigel H

“…Neuronal dysfunction and demise together with a reduction in neurogenesis are cardinal features of Alzheimer's disease (AD) induced by a combination of…”
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Neural Stem Cell Transplant-Induced Effect on Neurogenesis and Cognition in Alzheimer Tg2576 Mice Is Inhibited by Concomitant Treatment with Amyloid-Lowering or Cholinergic α7 Nicotinic Receptor Drugs by Lilja, Anna M, Malmsten, Linn, Röjdner, Jennie, Voytenko, Larysa, Verkhratsky, Alexei, Ögren, Sven Ove, Nordberg, Agneta, Marutle, Amelia

“…Stimulating regeneration in the brain has the potential to rescue neuronal networks and counteract progressive pathological changes in Alzheimer's disease…”
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Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study by Rodriguez-Vieitez, Elena, Ni, Ruiqing, Gulyás, Balázs, Tóth, Miklós, Häggkvist, Jenny, Halldin, Christer, Voytenko, Larysa, Marutle, Amelia, Nordberg, Agneta

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