Search Results - "Maruta, Hiroshi"

Chemical evolution for taming the ‘pathogenic kinase’ PAK1 by Maruta, Hiroshi, Kittaka, Atsushi

“…•PAK1 is the major ‘pathogenic’ kinase.•Several potent PAK1 blockers developed are introduced for treatment of a wide variety of PAK1-dependent diseases…”
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Rapamycin vs TORin-1 or Gleevec vs Nilotinib: Simple chemical evolution that converts PAK1-blockers to TOR-blockers or vice versa? by Maruta, Hiroshi, He, Hong

“…Both PAK1 (RAC/CDC42-activating kinase 1) and TOR (Target of Rapamycin) are among the major oncogenic/ageing kinases. However, they play the opposite role in…”
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From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy by Maruta, Hiroshi, Ahn, Mok-Ryeon

“…PAK family kinases are RAC/CDC42-activated kinases that were first found in a soil amoeba 4 decades ago, and 2 decades later, were discovered in mammals as…”
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Probiotic microbes: Are their anti-melanogenicity and longevity promoting activities closely linked through the major "pathogenic" kinase PAK1? by Maruta, Hiroshi, Ahn, Mok-Ryeon

“…PAK1-deficient mutant of C. elegans lives 60% longer than the wild-type. Interestingly, PAK1-deficient mutant of melanocytes produces less melanin (only a half…”
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1,2,3-Triazolyl ester of Ketorolac: A “Click Chemistry”-based highly potent PAK1-blocking cancer-killer by Nguyen, Binh Cao Quan, Takahashi, Hideaki, Uto, Yoshihiro, Shahinozzaman, M.d., Tawata, Shinkichi, Maruta, Hiroshi

“…An old anti-inflammatory/analgesic drug called Toradol is a racemic form of Ketorolac (50% R-form and 50% S-form) that blocks the oncogenic RAC-PAK1-COX-2…”
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Artepillin C and Other Herbal PAK1‐blockers: Effects on Hair Cell Proliferation and Related PAK1‐dependent Biological Function in Cell Culture by Nguyen, Binh Cao Quan, Taira, Nozomi, Maruta, Hiroshi, Tawata, Shinkichi

“…PAK1 (RAC/CDC42‐activated kinase 1) is the major oncogenic kinase, and a number of herbal PAK1‐blockers such as propolis and curcumin have been shown to be…”
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PAK1-blockers: Potential Therapeutics against COVID-19 by Maruta, Hiroshi, He, Hong

“…PAK1 (RAC/CDC42-activated kinase 1) is the major “pathogenic” kinase whose abnormal activation causes a wide variety of diseases/disorders including cancers,…”
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Frondoside A from sea cucumber and nymphaeols from Okinawa propolis: Natural anti-cancer agents that selectively inhibit PAK1 in vitro by Nguyen, Binh Cao Quan, Yoshimura, Kazuki, Kumazawa, Shigenori, Tawata, Shinkichi, Maruta, Hiroshi

“…A sulfated saponin called "Frondoside A" (FRA) from sea cucumber and ingredients from Okinawa propolis (OP) have been previously shown to suppress the…”
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Alert Regarding Cisplatin-induced Severe Adverse Events in Cancer Patients with Xeroderma Pigmentosum by Sumiyoshi, Makoto, Soda, Hiroshi, Sadanaga, Noriaki, Taniguchi, Hirokazu, Ikeda, Takaya, Maruta, Hiroshi, Dotsu, Yosuke, Ogawara, Daiki, Fukuda, Yuichi, Mukae, Hiroshi

“…Xeroderma pigmentosum (XP) is a genetic disease in which DNA repair mechanisms are impaired. Cisplatin (CDDP) exerts cytotoxic effects by forming mainly…”
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1,2,3-Triazolyl esterization of PAK1-blocking propolis ingredients, artepillin C (ARC) and caffeic acid (CA), for boosting their anti-cancer/anti-PAK1 activities along with cell-permeability by Takahashi, Hideaki, Nguyen, Binh Cao Quan, Uto, Yoshihiro, Shahinozzaman, Md, Tawata, Shinkichi, Maruta, Hiroshi

“…Artepillin C (ARC) and caffeic acid (CA) are among the major anti-cancer ingredients of propolis, and block the oncogenic/melanogenic/ageing kinase PAK1…”
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Effective neurofibromatosis therapeutics blocking the oncogenic kinase PAK1 by Maruta, Hiroshi

“…Neurofibromatosis (NF) is a family of genetic diseases which are caused by dysfunction of either NF1 gene or NF2 gene. One in 3,000 people suffer from this…”
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1,2,3-Triazolyl ester of ketorolac (15K), a potent PAK1 blocker, inhibits both growth and metastasis of orthotopic human pancreatic cancer xenografts in mice by Hennig, Rene, Albawardi, Alia, Almarzooqi, Saeeda, Haneefa, Shoja, Imbaraj, Edward, Zaaba, Nur Elena, Nemmar, Abderrahim, Subramanya, Sandeep, Maruta, Hiroshi, Adrian, Thomas E.

“…More than 90% of human pancreatic cancers carry the oncogenic mutant of Ki-RAS and their growth depends on its downstream kinase PAK1, mainly because PAK1…”
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Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice by Messerli, Shanta M, Ahn, Mok-Ryeon, Kunimasa, Kazuhiro, Yanagihara, Miyako, Tatefuji, Tomoki, Hashimoto, Ken, Mautner, Victor, Uto, Yoshihiro, Hori, Hitoshi, Kumazawa, Shigenori, Kaji, Kazuhiko, Ohta, Toshiro, Maruta, Hiroshi

“…There are mainly three types of propolis whose major anticancer ingredients are entirely different: (1) CAPE (caffeic acid phenethyl ester)-based propolis in…”
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1,2,3-Triazolyl ester of ketorolac (15K): Boosting both heat-endurance and lifespan of C. elegans by down-regulating PAK1 at nM levels by Nguyen, Binh C., Kim, Sung-A, Won, Seong-Min, Park, Sang-Kyu, Uto, Yoshihiro, Maruta, Hiroshi

“…PAK1 (RAC/CDC42-activated kinase 1) is the major oncogenic/ageing kinase, and its dysfunction extends the healthy lifespan of C. elegans by activating HSP16…”
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PAK1-deficiency/down-regulation reduces brood size, activates HSP16.2 gene and extends lifespan in Caenorhabditis elegans by Yanase, Sumino, Luo, Yuan, Maruta, Hiroshi

“…There is an increasing evidence that the oncogenic kinase PAK1 is responsible not only for malignant transformation, but also for several other diseases such…”
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Both triazolyl ester of ketorolac (15K) and YM155 inhibit the embryonic angiogenesis in ovo (fertilized eggs) via their common PAK1-survivin/VEGF signaling pathway by Ahn, Mok-Ryeon, Bae, Ji-Yeon, Jeong, Da-Hye, Takahashi, Hideaki, Uto, Yoshihiro, Maruta, Hiroshi

“…15 K is 1,2, 3-triazolyl ester of ketorolac, an old pain-killer, that blocks PAK1 by its R-form and inhibits COX-2 by its S-form. Mainly due to a robust…”
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Herbal Therapeutics that Block the Oncogenic Kinase PAK1: A Practical Approach towards PAK1‐dependent Diseases and Longevity by Maruta, Hiroshi

“…Over 35 years research on PAKs, RAC/CDC42(p21)‐activated kinases, comes of age, and in particular PAK1 has been well known to be responsible for a variety of…”
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Combination of immunoprecipitation (IP)-ATP_Glo kinase assay and melanogenesis for the assessment of potent and safe PAK1-blockers in cell culture by Nguyen, Binh Cao Quan, Tu, Pham Thi Be, Tawata, Shinkichi, Maruta, Hiroshi

“…Cucurbitacin I (CBI) is a triterpene from a bitter melon called Goya grown in Okinawa, Japan, and directly inhibits both the Tyr-kinase JAK2 and the G protein…”
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The serum/PDGF-dependent "melanogenic" role of the minute level of the oncogenic kinase PAK1 in melanoma cells proven by the highly sensitive kinase assay by Tu, Pham Thi Be, Nguyen, Binh Cao Quan, Tawata, Shinkichi, Yun, Cheong-Yong, Kim, Eung Gook, Maruta, Hiroshi

“…We previously demonstrated that the oncogenic kinase PAK4, which both melanomas and normal melanocytes express at a very high level, is essential for their…”
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Signal therapy of human pancreatic cancer and NF1 -deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors) by Hirokawa, Yumiko, Levitzki, Alexander, Lessene, Guillaume, Baell, Jonathan, Xiao, Yi, Zhu, Hongjian, Maruta, Hiroshi

“…Abstract The majority of cancers are caused by mutations of a few signal transducers such as the GTPase RAS, the kinase Src and the tumor suppressor p53. Thus,…”
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