Search Results - "Maruotti, Julien"

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells by Wahlin, Karl J., Maruotti, Julien A., Sripathi, Srinivasa R., Ball, John, Angueyra, Juan M., Kim, Catherine, Grebe, Rhonda, Li, Wei, Jones, Bryan W., Zack, Donald J.

“…The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of…”
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Expansion of the CRISPR–Cas9 genome targeting space through the use of H1 promoter-expressed guide RNAs by Ranganathan, Vinod, Wahlin, Karl, Maruotti, Julien, Zack, Donald J.

“…The repurposed CRISPR–Cas9 system has recently emerged as a revolutionary genome-editing tool. Here we report a modification in the expression of the guide RNA…”
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New insights into the role of Cutibacterium acnes-derived extracellular vesicles in inflammatory skin disorders by Cros, Maria Pol, Mir-Pedrol, Júlia, Toloza, Lorena, Knödlseder, Nastassia, Maruotti, Julien, Zouboulis, Christos C., Güell, Marc, Fábrega, Maria-José

“…Cutibacterium acnes ( C. acnes ) is one of the most prevalent bacteria that forms the human skin microbiota. Specific phylotypes of C. acnes have been…”
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Small-molecule–directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells by Maruotti, Julien, Sripathi, Srinivas R., Bharti, Kapil, Fuller, John, Wahlin, Karl J., Ranganathan, Vinod, Sluch, Valentin M., Berlinicke, Cynthia A., Davis, Janine, Kim, Catherine, Zhao, Lijun, Wan, Jun, Qian, Jiang, Corneo, Barbara, Temple, Sally, Dubey, Ramin, Olenyuk, Bogdan Z., Bhutto, Imran, Lutty, Gerard A., Zack, Donald J.

“…Age-related macular degeneration (AMD) is associated with dysfunction and death of retinal pigment epithelial (RPE) cells. Cell-based approaches using RPE-like…”
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Author Correction: New insights into the role of Cutibacterium acnes-derived extracellular vesicles in inflammatory skin disorders by Cros, Maria Pol, Mir-Pedrol, Júlia, Toloza, Lorena, Knödlseder, Nastassia, Maruotti, Julien, Zouboulis, Christos C., Güell, Marc, Fábrega, Maria-José

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Author Correction: New insights into the role of Cutibacterium acnes-derived extracellular vesicles in inflammatory skin disorders by Cros, Maria Pol, Mir-Pedrol, Júlia, Toloza, Lorena, Knödlseder, Nastassia, Maruotti, Julien, Zouboulis, Christos C., Güell, Marc, Fábrega, Maria-José

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A Simple and Scalable Process for the Differentiation of Retinal Pigment Epithelium From Human Pluripotent Stem Cells by Maruotti, Julien, Wahlin, Karl, Gorrell, David, Bhutto, Imran, Lutty, Gerard, Zack, Donald J.

“…This study describes a simple and scalable protocol for the generation of retinal pigment epithelial (RPE) cells from human pluripotent stem cells (hPSCs) that…”
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Transcription Factor SOX9 Plays a Key Role in the Regulation of Visual Cycle Gene Expression in the Retinal Pigment Epithelium by Masuda, Tomohiro, Wahlin, Karl, Wan, Jun, Hu, Jianfei, Maruotti, Julien, Yang, Xue, Iacovelli, Jared, Wolkow, Natalie, Kist, Ralf, Dunaief, Joshua L., Qian, Jiang, Zack, Donald J., Esumi, Noriko

“…The retinal pigment epithelium (RPE) performs specialized functions to support retinal photoreceptors, including regeneration of the visual chromophore…”
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IKKβ Inhibition Attenuates Epithelial Mesenchymal Transition of Human Stem Cell-Derived Retinal Pigment Epithelium by Sripathi, Srinivasa R, Hu, Ming-Wen, Turaga, Ravi Chakra, Mikeasky, Rebekah, Satyanarayana, Ganesh, Cheng, Jie, Duan, Yukan, Maruotti, Julien, Wahlin, Karl J, Berlinicke, Cynthia A, Qian, Jiang, Esumi, Noriko, Zack, Donald J

“…Epithelial-mesenchymal transition (EMT), which is well known for its role in embryonic development, malignant transformation, and tumor progression, has also…”
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Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states by Dirks, René A M, van Mierlo, Guido, Kerstens, Hindrik H D, Bernardo, Andreia S, Kobolák, Julianna, Bock, István, Maruotti, Julien, Pedersen, Roger A, Dinnyés, András, Huynen, Martijn A, Jouneau, Alice, Marks, Hendrik

“…Genomic imprinting, resulting in parent-of-origin specific gene expression, plays a critical role in mammalian development. Here, we apply allele-specific…”
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A high‐throughput screening platform for pigment regulating agents using pluripotent stem cell‐derived melanocytes by Parat, Valentin, Onteniente, Brigitte, Maruotti, Julien

“…In this study, we describe a simple and straightforward assay using induced pluripotent stem cell‐derived melanocytes and high‐throughput flow cytometry, to…”
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Delivery of a sebum modulator by an engineered skin microbe in mice by Knödlseder, Nastassia, Fábrega, María-José, Santos-Moreno, Javier, Manils, Joan, Toloza, Lorena, Marín Vilar, Maria, Fernández, Cristina, Broadbent, Katrina, Maruotti, Julien, Lemenager, Hélène, Carolis, Carlo, Zouboulis, Christos C., Soler, Concepció, Lood, Rolf, Brüggemann, Holger, Güell, Marc

“…Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant…”
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Proteome Landscape of Epithelial-to-Mesenchymal Transition (EMT) of Retinal Pigment Epithelium Shares Commonalities With Malignancy-Associated EMT by Sripathi, Srinivasa R., Hu, Ming-Wen, Turaga, Ravi Chakra, Mertz, Joseph, Liu, Melissa M., Wan, Jun, Maruotti, Julien, Wahlin, Karl J., Berlinicke, Cynthia A., Qian, Jiang, Zack, Donald J.

“…Stress and injury to the retinal pigment epithelium (RPE) often lead to dedifferentiation and epithelial-to-mesenchymal transition (EMT). These processes have…”
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Transcriptome Landscape of Epithelial to Mesenchymal Transition of Human Stem Cell-Derived RPE by Sripathi, Srinivasa R, Hu, Ming-Wen, Liu, Melissa M, Wan, Jun, Cheng, Jie, Duan, Yukan, Mertz, Joseph L, Wahlin, Karl J, Maruotti, Julien, Berlinicke, Cynthia A, Qian, Jiang, Zack, Donald J

“…RPE injury often induces epithelial to mesenchymal transition (EMT). Although RPE-EMT has been implicated in a variety of retinal diseases, including…”
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Generation of highly pure pluripotent stem cell-derived myogenic progenitor cells and myotubes by Bou Akar, Reem, Lama, Chéryane, Aubin, Déborah, Maruotti, Julien, Onteniente, Brigitte, Esteves de Lima, Joana, Relaix, Frédéric

“…Driving efficient and pure skeletal muscle cell differentiation from pluripotent stem cells (PSCs) has been challenging. Here, we report an optimized protocol…”
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Modeling retinal dystrophies using patient-derived induced pluripotent stem cells by Wahlin, Karl J, Maruotti, Julien, Zack, Donald J

“…Retinal degenerative disease involving photoreceptor (PR) cell loss results in permanent vision loss and often blindness. Generation of induced pluripotent…”
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MITF-M, a 'melanocyte-specific' isoform, is expressed in the adult retinal pigment epithelium by Maruotti, Julien, Thein, Thuzar, Zack, Donald J., Esumi, Noriko

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Collagen vitrigels with low‐fibril density enhance human embryonic stem cell‐derived retinal pigment epithelial cell maturation by Wang, Xiaokun, Maruotti, Julien, Majumdar, Shoumyo, Roman, Jose, Mao, Hai‐Quan, Zack, Donald J., Elisseeff, Jennifer H.

“…Structural and biochemical cues of extracellular matrix can substantially influence the differentiation and maturation of cultured retinal pigment epithelial…”
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Efficient derivation of bovine embryonic stem cells needs more than active core pluripotency factors by Maruotti, Julien, Muñoz, Marta, Degrelle, Severine A., Gómez, Enrique, Louet, Claire, Monforte, Carmen Díez, de Longchamp, Priscille Huot, Brochard, Vincent, Hue, Isabelle, Caamaño, José Nestor, Jouneau, Alice

“…Pluripotency can be captured in vitro, providing that the culture environment meets the requirements that avoid differentiation while stimulating self‐renewal…”
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Nuclear Transfer‐Derived Epiblast Stem Cells Are Transcriptionally and Epigenetically Distinguishable from Their Fertilized‐Derived Counterparts by Maruotti, Julien, Dai, Xiang Peng, Brochard, Vincent, Jouneau, Luc, Liu, Jun, Bonnet‐Garnier, Amélie, Jammes, Hélène, Vallier, Ludovic, Brons, I. Gabrielle M., Pedersen, Roger, Renard, Jean‐Paul, Zhou, Qi, Jouneau, Alice

“…Mouse embryonic pluripotent stem cells can be obtained from the inner cell mass at the blastocyst stage (embryonic stem cells, ESCs) or from the late epiblast…”
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