Search Results - "Maruno, Takahisa"

Mapping biopsy for bile duct cancer using a novel device delivery system by Matsumori, Tomoaki, Uza, Norimitsu, Shiokawa, Masahiro, Maruno, Takahisa, Kuwada, Takeshi, Marui, Saiko, Seno, Hiroshi

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Lineage tracing and targeting of IL17RB⁺ tuft cell-like human colorectal cancer stem cells by Goto, Norihiro, Fukuda, Akihisa, Yamaga, Yuichi, Yoshikawa, Takaaki, Maruno, Takahisa, Maekawa, Hisatsugu, Inamoto, Susumu, Kawada, Kenji, Sakai, Yoshiharu, Miyoshi, Hiroyuki, Taketo, Makoto Mark, Chiba, Tsutomu, Seno, Hiroshi

“…Cancer stem cell (CSC)-specific markers may be potential therapeutic targets. We previously identified that Dclk1, a tuft cell marker, marks tumor stem cells…”
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ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice by Kimura, Yoshito, Fukuda, Akihisa, Ogawa, Satoshi, Maruno, Takahisa, Takada, Yutaka, Tsuda, Motoyuki, Hiramatsu, Yukiko, Araki, Osamu, Nagao, Munemasa, Yoshikawa, Takaaki, Ikuta, Kozo, Yoshioka, Takuto, Wang, Zong, Akiyama, Haruhiko, Wright, Christopher V., Takaori, Kyoichi, Uemoto, Shinji, Chiba, Tsutomu, Seno, Hiroshi

“…The ARID1A gene encodes a protein that is part of the large adenosine triphosphate (ATP)-dependent chromatin remodeling complex SWI/SNF and is frequently…”
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Essential role of Notch/Hes1 signaling in postnatal pancreatic exocrine development by Kuriyama, Katsutoshi, Kodama, Yuzo, Shiokawa, Masahiro, Nishikawa, Yoshihiro, Marui, Saiko, Kuwada, Takeshi, Sogabe, Yuko, Kakiuchi, Nobuyuki, Tomono, Teruko, Matsumori, Tomoaki, Mima, Atsushi, Morita, Toshihiro, Ueda, Tatsuki, Tsuda, Motoyuki, Yamauchi, Yuki, Sakuma, Yojiro, Ota, Yuji, Maruno, Takahisa, Uza, Norimitsu, Kageyama, Ryoichiro, Chiba, Tsutomu, Seno, Hiroshi

“…Background Notch/Hes1 signaling has been shown to play a role in determining the fate of pancreatic progenitor cells. However, its function in postnatal…”
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Loss of Arid1a and Pten in Pancreatic Ductal Cells Induces Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway by Fukunaga, Yuichi, Fukuda, Akihisa, Omatsu, Mayuki, Namikawa, Mio, Sono, Makoto, Masuda, Tomonori, Araki, Osamu, Nagao, Munemasa, Yoshikawa, Takaaki, Ogawa, Satoshi, Hiramatsu, Yukiko, Muta, Yu, Tsuda, Motoyuki, Maruno, Takahisa, Nakanishi, Yuki, Ferrer, Jorge, Tsuruyama, Tatsuaki, Masui, Toshihiko, Hatano, Etsuro, Seno, Hiroshi

“…Pancreatic ductal adenocarcinoma (PDAC) arises from several types of premalignant lesions, including intraductal tubulopapillary neoplasm (ITPN); however, the…”
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Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging by Maruno, Takahisa, Fukuda, Akihisa, Goto, Norihiro, Tsuda, Motoyuki, Ikuta, Kozo, Hiramatsu, Yukiko, Ogawa, Satoshi, Nakanishi, Yuki, Yamaga, Yuichi, Yoshioka, Takuto, Takaori, Kyoichi, Uemoto, Shinji, Saur, Dieter, Chiba, Tsutomu, Seno, Hiroshi

“…Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. Although rigorous efforts identified the presence of 'cancer stem cells (CSCs)' in PDAC and…”
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SETDB1 Inhibits p53-Mediated Apoptosis and Is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice by Ogawa, Satoshi, Fukuda, Akihisa, Matsumoto, Yoshihide, Hanyu, Yuta, Sono, Makoto, Fukunaga, Yuichi, Masuda, Tomonori, Araki, Osamu, Nagao, Munemasa, Yoshikawa, Takaaki, Goto, Norihiro, Hiramatsu, Yukiko, Tsuda, Motoyuki, Maruno, Takahisa, Nakanishi, Yuki, Hussein, Mohammed S., Tsuruyama, Tatsuaki, Takaori, Kyoichi, Uemoto, Shinji, Seno, Hiroshi

“…SETDB1, a histone methyltransferase that trimethylates histone H3 on lysine 9, promotes development of several tumor types. We investigated whether SETDB1…”
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The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis by Tsuda, Motoyuki, Fukuda, Akihisa, Roy, Nilotpal, Hiramatsu, Yukiko, Leonhardt, Laura, Kakiuchi, Nobuyuki, Hoyer, Kaja, Ogawa, Satoshi, Goto, Norihiro, Ikuta, Kozo, Kimura, Yoshito, Matsumoto, Yoshihide, Takada, Yutaka, Yoshioka, Takuto, Maruno, Takahisa, Yamaga, Yuichi, Kim, Grace E, Akiyama, Haruhiko, Ogawa, Seishi, Wright, Christopher V, Saur, Dieter, Takaori, Kyoichi, Uemoto, Shinji, Hebrok, Matthias, Chiba, Tsutomu, Seno, Hiroshi

“…Chromatin remodeler Brahma related gene 1 (BRG1) is silenced in approximately 10% of human pancreatic ductal adenocarcinomas (PDAs). We previously showed that…”
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Arid1a is essential for intestinal stem cells through Sox9 regulation by Hiramatsu, Yukiko, Fukuda, Akihisa, Ogawa, Satoshi, Goto, Norihiro, Ikuta, Kozo, Tsuda, Motoyuki, Matsumoto, Yoshihide, Kimura, Yoshito, Yoshioka, Takuto, Takada, Yutaka, Maruno, Takahisa, Hanyu, Yuta, Tsuruyama, Tatsuaki, Wang, Zhong, Akiyama, Haruhiko, Takaishi, Shigeo, Miyoshi, Hiroyuki, Taketo, Makoto Mark, Chiba, Tsutomu, Seno, Hiroshi

“…Inactivating mutations of Arid1a, a subunit of the Switch/sucrose nonfermentable chromatin remodeling complex, have been reported in multiple human cancers…”
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Concomitant occurrence of pancreatic cancer during long-term follow-up for serous neoplasms by Matsumori, Tomoaki, Uza, Norimitsu, Shiokawa, Masahiro, Maruno, Takahisa, Seno, Hiroshi

“…[...]the biopsy sample used for the histological analysis was obtained using EUS-FNA. Declarations Conflict of interest The authors declare that there are no…”
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CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma by Morita, Toshihiro, Kodama, Yuzo, Shiokawa, Masahiro, Kuriyama, Katsutoshi, Marui, Saiko, Kuwada, Takeshi, Sogabe, Yuko, Matsumori, Tomoaki, Kakiuchi, Nobuyuki, Tomono, Teruko, Mima, Atsushi, Ueda, Tatsuki, Tsuda, Motoyuki, Yamauchi, Yuki, Nishikawa, Yoshihiro, Sakuma, Yojiro, Ota, Yuji, Maruno, Takahisa, Uza, Norimitsu, Nagasawa, Takashi, Chiba, Tsutomu, Seno, Hiroshi

“…Pancreatic ductal adenocarcinoma (PDAC) features abundant stromal cells with an excessive extracellular matrix (ECM), termed the desmoplastic reaction. CXCR4…”
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p53 protects against formation of extrahepatic biliary precancerous lesions in the context of oncogenic Kras by Nagao, Munemasa, Mizukoshi, Kenta, Nakayama, Shinnosuke, Namikawa, Mio, Hiramatsu, Yukiko, Maruno, Takahisa, Nakanishi, Yuki, Tsuruyama, Tatsuaki, Fukuda, Akihisa, Seno, Hiroshi

“…and mutations are frequently observed in extrahepatic biliary cancer. Mutations of and are independent risk factors for poor prognosis in biliary cancer…”
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THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer by Omatsu, Mayuki, Nakanishi, Yuki, Iwane, Kosuke, Aoyama, Naoki, Duran, Angeles, Muta, Yu, Martinez-Ordoñez, Anxo, Han, Qixiu, Agatsuma, Nobukazu, Mizukoshi, Kenta, Kawai, Munenori, Yamakawa, Go, Namikawa, Mio, Hamada, Kensuke, Fukunaga, Yuichi, Utsumi, Takahiro, Sono, Makoto, Masuda, Tomonori, Hata, Akitaka, Araki, Osamu, Nagao, Munemasa, Yoshikawa, Takaaki, Ogawa, Satoshi, Hiramatsu, Yukiko, Tsuda, Motoyuki, Maruno, Takahisa, Kogame, Toshiaki, Kasashima, Hiroaki, Kakiuchi, Nobuyuki, Nakagawa, Masahiro M., Kawada, Kenji, Yashiro, Masakazu, Maeda, Kiyoshi, Saito, Yasuyuki, Matozaki, Takashi, Fukuda, Akihisa, Kabashima, Kenji, Obama, Kazutaka, Ogawa, Seishi, Sheibani, Nader, Diaz-Meco, Maria T., Moscat, Jorge, Seno, Hiroshi

“…Mesenchymal activation, characterized by dense stromal infiltration of immune and mesenchymal cells, fuels the aggressiveness of colorectal cancers (CRC),…”
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Endoscopic stent placement above the intact sphincter of Oddi for biliary strictures after living donor liver transplantation by Kurita, Akira, Kodama, Yuzo, Minami, Ryuki, Sakuma, Yojiro, Kuriyama, Katsutoshi, Tanabe, Wataru, Ohta, Yuji, Maruno, Takahisa, Shiokawa, Masahiro, Sawai, Yugo, Uza, Norimitsu, Yazumi, Shujiro, Yoshizawa, Atsushi, Uemoto, Shinji, Chiba, Tsutomu

“…Background and study aims Biliary complications are one of the most serious morbidities after liver transplantation. Inside-stent is a plastic stent placed…”
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Brg1 is required to maintain colorectal cancer stem cells by Yoshikawa, Takaaki, Fukuda, Akihisa, Omatsu, Mayuki, Namikawa, Mio, Sono, Makoto, Fukunaga, Yuichi, Masuda, Tomonori, Araki, Osamu, Nagao, Munemasa, Ogawa, Satoshi, Masuo, Kenji, Goto, Norihiro, Hiramatsu, Yukiko, Muta, Yu, Tsuda, Motoyuki, Maruno, Takahisa, Nakanishi, Yuki, Kawada, Kenji, Takaishi, Shigeo, Seno, Hiroshi

“…Tumor cells capable of self‐renewal and continuous production of progeny cells are called tumor stem cells (TSCs) and are considered to be potential…”
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Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis by Nishikawa, Yoshihiro, Kodama, Yuzo, Shiokawa, Masahiro, Matsumori, Tomoaki, Marui, Saiko, Kuriyama, Katsutoshi, Kuwada, Takeshi, Sogabe, Yuko, Kakiuchi, Nobuyuki, Tomono, Teruko, Mima, Atsushi, Morita, Toshihiro, Ueda, Tatsuki, Tsuda, Motoyuki, Yamauchi, Yuki, Sakuma, Yojiro, Ota, Yuji, Maruno, Takahisa, Uza, Norimitsu, Uesugi, Motonari, Kageyama, Ryoichiro, Chiba, Tsutomu, Seno, Hiroshi

“…Most pancreatic ductal adenocarcinoma (PDAC) develops from pancreatic epithelial cells bearing activating mutant KRAS genes through precancerous lesions, i.e…”
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Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors by Yamauchi, Yuki, Kodama, Yuzo, Shiokawa, Masahiro, Kakiuchi, Nobuyuki, Marui, Saiko, Kuwada, Takeshi, Sogabe, Yuko, Tomono, Teruko, Mima, Atsushi, Morita, Toshihiro, Matsumori, Tomoaki, Ueda, Tatsuki, Tsuda, Motoyuki, Nishikawa, Yoshihiro, Kuriyama, Katsutoshi, Sakuma, Yojiro, Ota, Yuji, Maruno, Takahisa, Uza, Norimitsu, Masuda, Atsuhiro, Tatsuoka, Hisato, Yabe, Daisuke, Minamiguchi, Sachiko, Masui, Toshihiko, Inagaki, Nobuya, Uemoto, Shinji, Chiba, Tsutomu, Seno, Hiroshi

“…Pancreatic neuroendocrine tumors (PanNET) were classified into grades (G) 1 to 3 by the World Health Organization in 2017, but the precise mechanisms of PanNET…”
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Hes1 Is Essential in Proliferating Ductal Cell-Mediated Development of Intrahepatic Cholangiocarcinoma by Matsumori, Tomoaki, Kodama, Yuzo, Takai, Atsushi, Shiokawa, Masahiro, Nishikawa, Yoshihiro, Matsumoto, Tomonori, Takeda, Haruhiko, Marui, Saiko, Okada, Hirokazu, Hirano, Tomonori, Kuwada, Takeshi, Sogabe, Yuko, Kakiuchi, Nobuyuki, Tomono, Teruko, Mima, Atsushi, Morita, Toshihiro, Ueda, Tatsuki, Tsuda, Motoyuki, Yamauchi, Yuki, Kuriyama, Katsutoshi, Sakuma, Yojiro, Ota, Yuji, Maruno, Takahisa, Uza, Norimitsu, Marusawa, Hiroyuki, Kageyama, Ryoichiro, Chiba, Tsutomu, Seno, Hiroshi

“…Intrahepatic cholangiocarcinoma (ICC) is frequently driven by aberrant activation and develops in the liver with chronic inflammation. Although the Notch…”
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Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis by Masuda, Tomonori, Fukuda, Akihisa, Yamakawa, Go, Omatsu, Mayuki, Namikawa, Mio, Sono, Makoto, Fukunaga, Yuichi, Nagao, Munemasa, Araki, Osamu, Yoshikawa, Takaaki, Ogawa, Satoshi, Masuo, Kenji, Goto, Norihiro, Hiramatsu, Yukiko, Muta, Yu, Tsuda, Motoyuki, Maruno, Takahisa, Nakanishi, Yuki, Masui, Toshihiko, Hatano, Etsuro, Matsuzaki, Tomoko, Noda, Makoto, Seno, Hiroshi

“…RECK is downregulated in various human cancers; however, how RECK inactivation affects carcinogenesis remains unclear. We addressed this issue in a pancreatic…”
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JNK pathway plays a critical role for expansion of human colorectal cancer in the context of BRG1 suppression by Yoshikawa, Takaaki, Fukuda, Akihisa, Omatsu, Mayuki, Namikawa, Mio, Sono, Makoto, Fukunaga, Yuichi, Masuda, Tomonori, Araki, Osamu, Nagao, Munemasa, Ogawa, Satoshi, Masuo, Kenji, Goto, Norihiro, Hiramatsu, Yukiko, Muta, Yu, Tsuda, Motoyuki, Maruno, Takahisa, Nakanishi, Yuki, Kawada, Kenji, Takaishi, Shigeo, Seno, Hiroshi

“…Tumor stem cells (TSCs), capable of self‐renewal and continuous production of progeny cells, could be potential therapeutic targets. We have recently reported…”
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