Search Results - "Marunde, Matthew R"

The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape by Weinberg, Daniel N., Papillon-Cavanagh, Simon, Chen, Haifen, Yue, Yuan, Chen, Xiao, Rajagopalan, Kartik N., Horth, Cynthia, McGuire, John T., Xu, Xinjing, Nikbakht, Hamid, Lemiesz, Agata E., Marchione, Dylan M., Marunde, Matthew R., Meiners, Matthew J., Cheek, Marcus A., Keogh, Michael-Christopher, Bareke, Eric, Djedid, Anissa, Harutyunyan, Ashot S., Jabado, Nada, Garcia, Benjamin A., Li, Haitao, Allis, C. David, Majewski, Jacek, Lu, Chao

“…Enzymes that catalyse CpG methylation in DNA, including the DNA methyltransferases 1 (DNMT1), 3A (DNMT3A) and 3B (DNMT3B), are indispensable for mammalian…”
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Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands by Weinberg, Daniel N., Rosenbaum, Phillip, Chen, Xiao, Barrows, Douglas, Horth, Cynthia, Marunde, Matthew R., Popova, Irina K., Gillespie, Zachary B., Keogh, Michael-Christopher, Lu, Chao, Majewski, Jacek, Allis, C. David

“…Precise deposition of CpG methylation is critical for mammalian development and tissue homeostasis and is often dysregulated in human diseases. The…”
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Structure and flexibility of the yeast NuA4 histone acetyltransferase complex by Zukin, Stefan A, Marunde, Matthew R, Popova, Irina K, Soczek, Katarzyna M, Nogales, Eva, Patel, Avinash B

“…The NuA4 protein complex acetylates histones H4 and H2A to activate both transcription and DNA repair. We report the 3.1-Å resolution cryo-electron microscopy…”
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Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions by Jain, Kanishk, Fraser, Caroline S, Marunde, Matthew R, Parker, Madison M, Sagum, Cari, Burg, Jonathan M, Hall, Nathan, Popova, Irina K, Rodriguez, Keli L, Vaidya, Anup, Krajewski, Krzysztof, Keogh, Michael-Christopher, Bedford, Mark T, Strahl, Brian D

“…Plant homeodomain (PHD) fingers are central "readers" of histone post-translational modifications (PTMs) with > 100 PHD finger-containing proteins encoded by…”
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Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers by Wilcox, Kyle C, Marunde, Matthew R, Das, Aditi, Velasco, Pauline T, Kuhns, Benjamin D, Marty, Michael T, Jiang, Haoming, Luan, Chi-Hao, Sligar, Stephen G, Klein, William L

“…Despite their value as sources of therapeutic drug targets, membrane proteomes are largely inaccessible to high-throughput screening (HTS) tools designed for…”
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Independent transcriptomic and proteomic regulation by type I and II protein arginine methyltransferases by Maron, Maxim I., Lehman, Stephanie M., Gayatri, Sitaram, DeAngelo, Joseph D., Hegde, Subray, Lorton, Benjamin M., Sun, Yan, Bai, Dina L., Sidoli, Simone, Gupta, Varun, Marunde, Matthew R., Bone, James R., Sun, Zu-Wen, Bedford, Mark T., Shabanowitz, Jeffrey, Chen, Hongshan, Hunt, Donald F., Shechter, David

“…Protein arginine methyltransferases (PRMTs) catalyze the post-translational monomethylation (Rme1), asymmetric (Rme2a), or symmetric (Rme2s) dimethylation of…”
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Improved tolerance to salt and water stress in Drosophila melanogaster cells conferred by late embryogenesis abundant protein by Marunde, Matthew R., Samarajeewa, Dilini A., Anderson, John, Li, Shumin, Hand, Steven C., Menze, Michael A.

“…[Display omitted] ► The protein AfLEA1.3 (A. franciscana) accumulates in mitochondria (D. melanogaster) ► AfLEA1.3 improves mitochondrial functions in presence…”
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A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization by Dilworth, David, Hanley, Ronan P., Ferreira de Freitas, Renato, Allali-Hassani, Abdellah, Zhou, Mengqi, Mehta, Naimee, Marunde, Matthew R., Ackloo, Suzanne, Carvalho Machado, Raquel Arminda, Khalili Yazdi, Aliakbar, Owens, Dominic D. G., Vu, Victoria, Nie, David Y., Alqazzaz, Mona, Marcon, Edyta, Li, Fengling, Chau, Irene, Bolotokova, Albina, Qin, Su, Lei, Ming, Liu, Yanli, Szewczyk, Magdalena M., Dong, Aiping, Kazemzadeh, Sina, Abramyan, Tigran, Popova, Irina K., Hall, Nathan W., Meiners, Matthew J., Cheek, Marcus A., Gibson, Elisa, Kireev, Dmitri, Greenblatt, Jack F., Keogh, Michael-C., Min, Jinrong, Brown, Peter J., Vedadi, Masoud, Arrowsmith, Cheryl H., Barsyte-Lovejoy, Dalia, James, Lindsey I., Schapira, Matthieu

“…Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark…”
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The dCypher Approach to Interrogate Chromatin Reader Activity Against Posttranslational Modification-Defined Histone Peptides and Nucleosomes by Marunde, Matthew R, Popova, Irina K, Weinzapfel, Ellen N, Keogh, Michael-C

“…Bulk chromatin encompasses complex sets of histone posttranslational modifications (PTMs) that recruit (or repel) the diverse reader domains of…”
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A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer by Morgan, Marc A J, Popova, Irina K, Vaidya, Anup, Burg, Jonathan M, Marunde, Matthew R, Rendleman, Emily J, Dumar, Zachary J, Watson, Rachel, Meiners, Matthew J, Howard, Sarah A, Khalatyan, Natalia, Vaughan, Robert M, Rothbart, Scott B, Keogh, Michael-C, Shilatifard, Ali

“…Mutations in the chromatin regulator cause the human neurodevelopmental disorder Chung-Jansen syndrome, while alterations in expression are linked to cancer…”
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Quantification of citrullinated histones: Development of an improved assay to reliably quantify nucleosomal H3Cit in human plasma by Thålin, Charlotte, Aguilera, Katherina, Hall, Nathan W., Marunde, Matthew R., Burg, Jonathan M., Rosell, Axel, Daleskog, Maud, Månsson, Maja, Hisada, Yohei, Meiners, Matthew J., Sun, Zu‐Wen, Whelihan, Matthew F., Cheek, Marcus A., Howard, Sarah A., Saxena‐Beem, Shruti, Noubouossie, Denis F., Key, Nigel S., Sheikh, Saira Z., Keogh, Michael‐Christopher, Cowles, Martis W., Lundström, Staffan, Mackman, Nigel, Wallén, Håkan, Johnstone, Andrea L.

“…Background Recent data propose a diagnostic and prognostic capacity for citrullinated histone H3 (H3Cit), a marker of neutrophil extracellular traps (NETs), in…”
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Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain by Lloyd, Jonathan T, McLaughlin, Kyle, Lubula, Mulu Y, Gay, Jamie C, Dest, Andrea, Gao, Cong, Phillips, Margaret, Tonelli, Marco, Cornilescu, Gabriel, Marunde, Matthew R, Evans, Chiara M, Boyson, Samuel P, Carlson, Samuel, Keogh, Michael-Christopher, Markley, John L, Frietze, Seth, Glass, Karen C

“…Bromodomains exhibit preferences for specific patterns of post-translational modifications on core and variant histone proteins. We examined the ligand…”
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Reading the message: Connections between the epigenetic landscape bromodomain activity by Glass, Karen C., Montgomery, Cameron, Lloyd, Jonathan T., McLaughlin, Kyle, Marunde, Matthew R., Evans, Chiara M., Boyson, Samuel P., Keogh, Michael‐Christopher, Frietze, Seth

“…Bromodomains are conserved epigenetic reader domains known to recognize acetylated lysine residues on the N‐terminal histone tails protruding from the…”
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An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability by Jain, Kanishk, Marunde, Matthew R, Burg, Jonathan M, Gloor, Susan L, Joseph, Faith M, Poncha, Karl F, Gillespie, Zachary B, Rodriguez, Keli L, Popova, Irina K, Hall, Nathan W, Vaidya, Anup, Howard, Sarah A, Taylor, Hailey F, Mukhsinova, Laylo, Onuoha, Ugochi C, Patteson, Emily F, Cooke, Spencer W, Taylor, Bethany C, Weinzapfel, Ellen N, Cheek, Marcus A, Meiners, Matthew J, Fox, Geoffrey C, Namitz, Kevin E W, Cowles, Martis W, Krajewski, Krzysztof, Sun, Zu-Wen, Cosgrove, Michael S, Young, Nicolas L, Keogh, Michael-Christopher, Strahl, Brian D

“…In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to…”
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Nucleosome conformation dictates the histone code by Marunde, Matthew R, Fuchs, Harrison A, Burg, Jonathan M, Popova, Irina K, Vaidya, Anup, Hall, Nathan W, Weinzapfel, Ellen N, Meiners, Matthew J, Watson, Rachel, Gillespie, Zachary B, Taylor, Hailey F, Mukhsinova, Laylo, Onuoha, Ugochi C, Howard, Sarah A, Novitzky, Katherine, McAnarney, Eileen T, Krajewski, Krzysztof, Cowles, Martis W, Cheek, Marcus A, Sun, Zu-Wen, Venters, Bryan J, Keogh, Michael-C, Musselman, Catherine A

“…Histone post-translational modifications (PTMs) play a critical role in chromatin regulation. It has been proposed that these PTMs form localized 'codes' that…”
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Low-input chromatin profiling reveals inter- and intra-lineage differences across immune cell types by Bale, Michael J., Ahimovic, Dughan J., Lee, Juliana, Marunde, Matthew R., Lin, Carolina P., Maryanski, Danielle N., Keogh, Michael-Christopher, Josefowicz, Steven Z.

“…Abstract Transcriptional regulation in cells is governed by myriad traits that allow specific responses to ever-changing environments. Inclusive of these…”
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Automated Cut&run Brings Scalable Epigenomic Profiling to Hematology by Maier, Keith E, Marunde, Matthew R, U. Sunitha Kumary, Vishnu, Lin, Carolina P, Maryanski, Danielle N, Albertorio-Saez, Liz, Ahimovic, Dughan J, Bale, Michael J, Lee, Juliana J, Venters, Bryan J, Keogh, Michael-Christopher

“…Genome-wide association studies (GWAS) and corresponding transcriptomics research have been leveraged to identify disease risk variants in hematological…”
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Specificity and Affinity of BPTF PHD Finger and Bromodomain in the Context of the Nucleosome by Fuchs, Harrison A., Marunde, Matthew R., Popova, Irina K., Hall, Nathan, Burg, Jonathan M., Meiners, Matt J., Gillespie, Zachary, Cheek, Marcus A., Howard, Sarah A., Sun, Zu-Wen, Morrison, Emma A., Keogh, Michael-Christopher, Musselman, Catherine A.

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H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape by Weinberg, Daniel N., Papillon-Cavanagh, Simon, Chen, Haifen, Yue, Yuan, Chen, Xiao, Rajagopalan, Kartik N., Horth, Cynthia, McGuire, John T., Xu, Xinjing, Nikbakht, Hamid, Lemiesz, Agata E., Marchione, Dylan M., Marunde, Matthew R., Meiners, Matt, Cheek, Marcus, Keogh, Michael-Christopher, Bareke, Eric, Djedid, Anissa, Harutyunyan, Ashot S., Jabado, Nada, Garcia, Benjamin A., Li, Haitao, Allis, C. David, Majewski, Jacek, Lu, Chao

“…Enzymes catalyzing CpG methylation in DNA, including DNMT1 and DNMT3A/B, are indispensable for mammalian tissue development and homeostasis 1 – 4 . They are…”
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Abstract P17: Epigenomic fingerprinting of limited primary immune cells using automated CUT&RUN by Weinzapfel, Ellen N., Maier, Keith E., Marunde, Matthew R., Kumary, Vishnu U. Sunitha, Windham, Carolina P. Lin, Maryanski, Danielle N, Albertorio-Saez, Liz, Ahimovic, Dughan J., Bale, Michael J., Lee, Juliana J., Venters, Bryan J., Keogh, Michael-Christopher

“…Abstract Chromatin structure drives gene expression programs during immune cell development and in cancer, making it central to the advancement of precision…”
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