Search Results - "Marucci, Lucia"

Nanog Dynamics in Mouse Embryonic Stem Cells: Results from Systems Biology Approaches by Marucci, Lucia

“…Mouse embryonic stem cells (mESCs), derived from the inner cell mass of the blastocyst, are pluripotent stem cells having self-renewal capability and the…”
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Designing minimal genomes using whole-cell models by Rees-Garbutt, Joshua, Chalkley, Oliver, Landon, Sophie, Purcell, Oliver, Marucci, Lucia, Grierson, Claire

“…In the future, entire genomes tailored to specific functions and environments could be designed using computational tools. However, computational tools for…”
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Mathematical Models of Organoid Cultures by Montes-Olivas, Sandra, Marucci, Lucia, Homer, Martin

“…Organoids are engineered three-dimensional tissue cultures derived from stem cells and capable of self-renewal and self-organization into a variety of…”
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Author Correction: Designing minimal genomes using whole-cell models by Rees-Garbutt, Joshua, Chalkley, Oliver, Landon, Sophie, Purcell, Oliver, Marucci, Lucia, Grierson, Claire

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Bridging the gap between mechanistic biological models and machine learning surrogates by Gherman, Ioana M, Abdallah, Zahraa S, Pang, Wei, Gorochowski, Thomas E, Grierson, Claire S, Marucci, Lucia

“…Mechanistic models have been used for centuries to describe complex interconnected processes, including biological ones. As the scope of these models has…”
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A Yeast Synthetic Network for In Vivo Assessment of Reverse-Engineering and Modeling Approaches by Cantone, Irene, Marucci, Lucia, Iorio, Francesco, Ricci, Maria Aurelia, Belcastro, Vincenzo, Bansal, Mukesh, Santini, Stefania, di Bernardo, Mario, di Bernardo, Diego, Cosma, Maria Pia

“…Systems biology approaches are extensively used to model and reverse engineer gene regulatory networks from experimental data. Conversely, synthetic biology…”
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A tunable dual-input system for on-demand dynamic gene expression regulation by Pedone, Elisa, Postiglione, Lorena, Aulicino, Francesco, Rocca, Dan L., Montes-Olivas, Sandra, Khazim, Mahmoud, di Bernardo, Diego, Pia Cosma, Maria, Marucci, Lucia

“…Cellular systems have evolved numerous mechanisms to adapt to environmental stimuli, underpinned by dynamic patterns of gene expression. In addition to gene…”
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In-silico and in-vitro morphometric analysis of intestinal organoids by Montes-Olivas, Sandra, Legge, Danny, Lund, Abbie, Fletcher, Alexander G, Williams, Ann C, Marucci, Lucia, Homer, Martin

“…Organoids offer a powerful model to study cellular self-organisation, the growth of specific tissue morphologies in-vitro, and to assess potential medical…”
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In Vivo Feedback Control of an Antithetic Molecular-Titration Motif in Escherichia coli Using Microfluidics by Shannon, Barbara, Zamora-Chimal, Criseida G., Postiglione, Lorena, Salzano, Davide, Grierson, Claire S., Marucci, Lucia, Savery, Nigel J., di Bernardo, Mario

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Understanding Metabolic Flux Behaviour in Whole-Cell Model Output by Landon, Sophie, Chalkley, Oliver, Breese, Gus, Grierson, Claire, Marucci, Lucia

“…Whole-cell modelling is a newly expanding field that has many applications in lab experiment design and predictive drug testing. Although whole-cell model…”
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Advanced medical micro-robotics for early diagnosis and therapeutic interventions by Zhang, Dandan, Gorochowski, Thomas E, Marucci, Lucia, Lee, Hyun-Taek, Gil, Bruno, Li, Bing, Hauert, Sabine, Yeatman, Eric

“…Recent technological advances in micro-robotics have demonstrated their immense potential for biomedical applications. Emerging micro-robots have versatile…”
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Regulation of Gene Expression and Signaling Pathway Activity in Mammalian Cells by Automated Microfluidics Feedback Control by Postiglione, Lorena, Napolitano, Sara, Pedone, Elisa, Rocca, Daniel L, Aulicino, Francesco, Santorelli, Marco, Tumaini, Barbara, Marucci, Lucia, di Bernardo, Diego

“…Gene networks and signaling pathways display complex topologies and, as a result, complex nonlinear behaviors. Accumulating evidence shows that both static…”
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β-Catenin Fluctuates in Mouse ESCs and Is Essential for Nanog-Mediated Reprogramming of Somatic Cells to Pluripotency by Marucci, Lucia, Pedone, Elisa, Di Vicino, Umberto, Sanuy-Escribano, Blanca, Isalan, Mark, Cosma, Maria Pia

“…The Wnt/β-catenin pathway and Nanog are key regulators of embryonic stem cell (ESC) pluripotency and the reprogramming of somatic cells. Here, we demonstrate…”
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Cross-talk between Hippo and Wnt signalling pathways in intestinal crypts: Insights from an agent-based model by Ward, Daniel, Montes Olivas, Sandra, Fletcher, Alexander, Homer, Martin, Marucci, Lucia

“…[Display omitted] Intestinal crypts are responsible for the total cell renewal of the lining of the intestines; this turnover is governed by the interplay…”
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Computer-Aided Whole-Cell Design: Taking a Holistic Approach by Integrating Synthetic With Systems Biology by Marucci, Lucia, Barberis, Matteo, Karr, Jonathan, Ray, Oliver, Race, Paul R, de Souza Andrade, Miguel, Grierson, Claire, Hoffmann, Stefan Andreas, Landon, Sophie, Rech, Elibio, Rees-Garbutt, Joshua, Seabrook, Richard, Shaw, William, Woods, Christopher

“…Computer-aided design (CAD) for synthetic biology promises to accelerate the rational and robust engineering of biological systems. It requires both detailed…”
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β-catenin perturbations control differentiation programs in mouse embryonic stem cells by Pedone, Elisa, Failli, Mario, Gambardella, Gennaro, De Cegli, Rossella, La Regina, Antonella, di Bernardo, Diego, Marucci, Lucia

“…The Wnt/β-catenin pathway is involved in development, cancer, and embryonic stem cell (ESC) maintenance; its dual role in stem cell self-renewal and…”
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Mathematical modeling reveals differential effects of erythropoietin on proliferation and lineage commitment of human hematopoietic progenitors in early erythroid culture by Ward, Daniel, Carter, Deborah, Homer, Martin, Marucci, Lucia, Gampel, Alexandra

“…Erythropoietin is essential for the production of mature erythroid cells, promoting both proliferation and survival. Whether erythropoietin and other cytokines…”
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Construction and modelling of an inducible positive feedback loop stably integrated in a mammalian cell-line by Siciliano, Velia, Menolascina, Filippo, Marucci, Lucia, Fracassi, Chiara, Garzilli, Immacolata, Moretti, Maria Nicoletta, di Bernardo, Diego

“…Understanding the relationship between topology and dynamics of transcriptional regulatory networks in mammalian cells is essential to elucidate the biology of…”
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Toward Engineering Biosystems With Emergent Collective Functions by Gorochowski, Thomas E, Hauert, Sabine, Kreft, Jan-Ulrich, Marucci, Lucia, Stillman, Namid R, Tang, T-Y Dora, Bandiera, Lucia, Bartoli, Vittorio, Dixon, Daniel O R, Fedorec, Alex J H, Fellermann, Harold, Fletcher, Alexander G, Foster, Tim, Giuggioli, Luca, Matyjaszkiewicz, Antoni, McCormick, Scott, Montes Olivas, Sandra, Naylor, Jonathan, Rubio Denniss, Ana, Ward, Daniel

“…Many complex behaviors in biological systems emerge from large populations of interacting molecules or cells, generating functions that go beyond the…”
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An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells by Godwin, Simon, Ward, Daniel, Pedone, Elisa, Homer, Martin, Fletcher, Alexander G., Marucci, Lucia

“…During development, pluripotency is a transient state describing a cell’s ability to give rise to all three germ layers and germline. Recent studies have shown…”
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