Search Results - "Maru, Saumya"

Pancreatic cancer is feeling the heat by Maru, Saumya Y, Jaffee, Elizabeth M

“…Pancreatic adenocarcinoma (PDAC) is considered an immunologically 'cold' tumor that fails to attract or support effector T cells. Most PDACs are resistant to…”
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TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection by Maru, Saumya, Jin, Ge, Schell, Todd D, Lukacher, Aron E

“…Establishing functional tissue-resident memory (TRM) cells at sites of infection is a newfound objective of T cell vaccine design. To directly assess the…”
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Myosin IIA Associates with NK Cell Lytic Granules to Enable Their Interaction with F-Actin and Function at the Immunological Synapse by Sanborn, Keri B, Rak, Gregory D, Maru, Saumya Y, Demers, Korey, Difeo, Analisa, Martignetti, John A, Betts, Michael R, Favier, Remi, Banerjee, Pinaki P, Orange, Jordan S

“…NK cell cytotoxicity requires the formation of an actin-rich immunological synapse (IS) with a target cell and the polarization of perforin-containing lytic…”
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Differential microRNA epression in asthma and the role of miR-1248 in regulation of IL-5 by Panganiban, Ronaldo Paolo L, Pinkerton, Mark H, Maru, Saumya Y, Jefferson, Sarah J, Roff, Alanna N, Ishmael, Faoud T

“…Asthma is a chronic inflammatory disease that can be difficult to manage due to a lack of diagnostic biomarkers and an incomplete understanding of the…”
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Inhibition of Retrograde Transport Limits Polyomavirus Infection In Vivo by Maru, Saumya, Jin, Ge, Desai, Dhimant, Amin, Shantu, Shwetank, Lauver, Matthew D, Lukacher, Aron E

“…Polyomaviruses (PyVs) silently infect most humans, but they can cause life-threatening diseases in immunocompromised individuals. The JC polyomavirus (JCPyV)…”
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RECURRENT LIPOID PNEUMONIA ASSOCIATED WITH MESOTHELIOMA by Maru, Saumya, Sahu, Nitasa

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A virus-encoded miRNA in mouse polyomavirus regulates viral replication in the kidneys in a CD8 T cell dependent manner. (VIR6P.1166) by Maru, Saumya, Lukacher, Aron

“…The polyomaviruses JCV and BKV are ubiquitous DNA viruses in the human population which persist as low-level infections in host kidneys and give rise to…”
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Increasing strength of antigenic stimulation negatively impacts memory CD8 T cell formation and function during persistent viral infection by Maru, Saumya, Haley, Jeremy S, Schell, Todd D, Lukacher, Aron

“…Memory CD8 T cells are critical for keeping persistent viral infections in check. Here, we used a novel approach to directly study the impact of T cell…”
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Abstract 3983: Antigen-presenting cancer-associated fibroblasts provide an alternate mechanism for CD4 T cell activation in murine pancreatic ductal adenocarcinoma by Maru, Saumya, Andaloori, Lalitya, Howe, Kathryn, Munjal, Kabeer, Leatherman, James, Pearce, Edward J., Jaffee, Elizabeth M.

“…Despite the advent of immune checkpoint inhibitors (ICI) that have markedly changed the treatment landscape for select tumors, pancreatic ductal adenocarcinoma…”
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Abstract B034: Antigen-presenting cancer-associated fibroblasts are found in immunotherapy-sensitive murine models of pancreatic ductal adenocarcinoma by Maru, Saumya, Howe, Kathryn, Andaloori, Lalitya, Leatherman, James, Tandurella, Joseph, Pearce, Edward J., Jaffee, Elizabeth M.

“…Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths. Despite the advent of immune checkpoint inhibition (ICI) that has markedly…”
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Reducing persistent polyomavirus infection increases functionality of virus-specific memory CD8 T cells by Qin, Qingsong, Lauver, Matthew, Maru, Saumya, Lin, Eugene, Lukacher, Aron E

“…Abstract Mouse polyomavirus (MuPyV) causes a smoldering persistent infection in immunocompetent mice. To lower MuPyV infection in acutely and persistently…”
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Cognate epitope is dispensable in maintenance of PD-1 expression on tissue-resident CD8+ cells by Shwetank, Frost, Elizabeth L., Abdelsamed, Hossam Aly, Mockus, Taryn, Maru, Saumya, Youngblood, Ben A, Lukacher, Aron

“…Persistent CNS infection by mouse polyomavirus (MuPyV) establishes a tissue-resident memory (TRM) CD8+ T cell population possessing higher TCR affinity than…”
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Type I Interferons Regulate the Magnitude and Functionality of Mouse Polyomavirus-Specific CD8 T Cells in a Virus Strain-Dependent Manner by Qin, Qingsong, Shwetank, Frost, Elizabeth L, Maru, Saumya, Lukacher, Aron E

“…Mouse polyomavirus (MPyV) is a ubiquitous persistent natural mouse pathogen. A glutamic acid (E)-to-glycine (G) difference at position 91 of the VP1 capsid…”
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Abstract B071: Antigen-presenting cancer-associated fibroblasts are required for ICI-sensitivity in pancreatic ductal adenocarcinoma by Maru, Saumya, Wetzel, Meredith, Mitchell, Jacob T, Gross, Nicole, Andaloori, Lalitya, Howe, Kathryn, Kartalia, Emma, Mo, Guanglan, Leatherman, James, Ho, Won Jin, Kagohara, Luciane, Fertig, Elana, Pearce, Edward J, Jaffee, Elizabeth M

“…Cancer-associated fibroblasts (CAFs) are a hallmark of many cancers and are particularly prevalent in pancreatic ductal adenocarcinoma (PDAC). This highly…”
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IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function by Orange, Jordan S, Roy-Ghanta, Sumita, Mace, Emily M, Maru, Saumya, Rak, Gregory D, Sanborn, Keri B, Fasth, Anders, Saltzman, Rushani, Paisley, Allison, Monaco-Shawver, Linda, Banerjee, Pinaki P, Pandey, Rahul

“…Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency associated with an increased susceptibility to herpesvirus infection and hematologic malignancy as…”
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Enhancing Host Control of Polyomavirus Infection by Maru, Saumya

“…Polyomaviruses are small, double-stranded DNA viruses that infect a wide range of host species. Seroprevalence of anti-PyV antibodies in the human population…”
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Inhibition of Retrograde Transport Limits Polyomavirus Infection italic toggle="yes">In Vivo /italic by Saumya Maru, Ge Jin, Dhimant Desai, Shantu Amin, Shwetank, Matthew D. Lauver, Aron E. Lukacher

“…ABSTRACT Polyomaviruses (PyVs) silently infect most humans, but they can cause life-threatening diseases in immunocompromised individuals. The JC polyomavirus…”
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Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse1 by Sanborn, Keri B., Rak, Gregory D., Maru, Saumya Y., Demers, Korey, Difeo, Analisa, Martignetti, John A, Betts, Michael R., Favier, Rémi, Banerjee, Pinaki P., Orange, Jordan S.

“…NK cell cytotoxicity requires the formation of an actin-rich immunological synapse (IS) with a target cell and the polarization of perforin-containing lytic…”
Get full text

Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse (134.13) by Sanborn, Keri B, Rak, Gregory D, Maru, Saumya Y, Difeo, Analisa, Martignetti, John A, Favier, Remi, Banerjee, Pinaki P, Orange, Jordan S

“…NK cell cytotoxicity requires the formation of an actin-rich immunological synapse (IS) with a target cell and the polarization of perforin-containing lytic…”
Get full text