Search Results - "Martyn, J. A Jeevendra"

Acute and Perioperative Care of the Burn-injured Patient by Bittner, Edward A, Shank, Erik, Woodson, Lee, Martyn, J. A Jeevendra

“…Care of burn-injured patients requires knowledge of the pathophysiologic changes affecting virtually all organs from the onset of injury until wounds are…”
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iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53 by Nakazawa, Harumasa, Chang, Kyungho, Shinozaki, Shohei, Yasukawa, Takashi, Ishimaru, Kazuhiro, Yasuhara, Shingo, Yu, Yong-Ming, Martyn, J A Jeevendra, Tompkins, Ronald G, Shimokado, Kentaro, Kaneki, Masao

“…Inflammation and apoptosis develop in skeletal muscle after major trauma, including burn injury, and play a pivotal role in insulin resistance and muscle…”
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Burn-Induced Microglia Activation is Associated With Motor Neuron Degeneration and Muscle Wasting in Mice by Ma, Li, Zhou, Yinhui, Khan, Mohammed A.S, Yasuhara, Shingo, Martyn, J. A Jeevendra

“…INTRODUCTION:Burn injury (BI) leads to both systemic and neuro-inflammation and is associated with muscle wasting and weakness, which increase morbidity and…”
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Primary role of functional ischemia, quantitative evidence for the two-hit mechanism, and phosphodiesterase-5 inhibitor therapy in mouse muscular dystrophy by Asai, Akihiro, Sahani, Nita, Kaneki, Masao, Ouchi, Yasuyoshi, Martyn, J A Jeevendra, Yasuhara, Shingo Egusa

“…Duchenne Muscular Dystrophy (DMD) is characterized by increased muscle damage and an abnormal blood flow after muscle contraction: the state of functional…”
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Prevention of Burn-Induced Inflammatory Responses and Muscle Wasting By GTS-21, A Specific Agonist for α7 Nicotinic Acetylcholine Receptors by Kashiwagi, Shizuka, Khan, Mohammed A S, Yasuhara, Shingo, Goto, Takahisa, Tompkins, Ronald G, Kaneki, Masao, Martyn, J. A Jeevendra

“…INTRODUCTION:Muscle wasting (MW) in catabolic conditions (e.g. burn injury, BI) is a major risk factor affecting prognosis. Activation of IL-1β/NF-κB,…”
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Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation by Nakazawa, Harumasa, Ikeda, Kazuhiro, Shinozaki, Shohei, Kobayashi, Masayuki, Ikegami, Yuichi, Fu, Ming, Nakamura, Tomoyuki, Yasuhara, Shingo, Yu, Yong-Ming, Martyn, J. A. Jeevendra, Tompkins, Ronald G., Shimokado, Kentaro, Yorozu, Tomoko, Ito, Hideki, Inoue, Satoshi, Kaneki, Masao

“…Metabolic derangements are a clinically significant complication of major trauma (e.g., burn injury) and include various aspects of metabolism, such as insulin…”
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Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle by Nakazawa, Harumasa, Yamada, Marina, Tanaka, Tomokazu, Kramer, Joshua, Yu, Yong-Ming, Fischman, Alan J, Martyn, J A Jeevendra, Tompkins, Ronald G, Kaneki, Masao

“…Metabolic derangements, including insulin resistance and hyperlactatemia, are a major complication of major trauma (e.g., burn injury) and affect the prognosis…”
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A small volatile bacterial molecule triggers mitochondrial dysfunction in murine skeletal muscle by Tzika, A Aria, Constantinou, Caterina, Bandyopadhaya, Arunava, Psychogios, Nikolaos, Lee, Sangseok, Mindrinos, Michael, Martyn, J A Jeevendra, Tompkins, Ronald G, Rahme, Laurence G

“…Mitochondria integrate distinct signals that reflect specific threats to the host, including infection, tissue damage, and metabolic dysfunction; and play a…”
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Muscle Atrophy and the Sestrins by Martyn, J.A. Jeevendra, Kaneki, Masao

“…Two recent scientific reports implicate the sestrin proteins in protecting against muscle atrophy, which occurs in old age and with disuse, denervation, and…”
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Opioid Tolerance in Critical Illness by Martyn, J.A. Jeevendra, Mao, Jianren, Bittner, Edward A

“…This review describes the indications for opioid therapy in patients in the intensive care unit, mechanisms of opioid tolerance, and current and potential…”
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Mitochondria, endoplasmic reticulum, and alternative pathways of cell death in critical illness by Yasuhara, Shingo, Asai, Akihiro, Sahani, Nita D, Martyn, J A. Jeevendra

“…Dying cells are distinguished by their biochemical and morphologic traits and categorized into three subtypesapoptosis, oncosis (necrosis), and cell death with…”
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Prolonged Administration of Pyridostigmine Impairs Neuromuscular Function with and without Down-regulation of Acetylcholine Receptors by Richtsfeld, Martina, Yasuhara, Shingo, Fink, Heidrun, Blobner, Manfred, Martyn, J. A Jeevendra

“…BACKGROUND:The acetylcholinesterase inhibitor, pyridostigmine, is prophylactically administered to mitigate the toxic effects of nerve gas poisoning. The…”
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Obesity-induced Insulin Resistance and Hyperglycemia : Etiologic Factors and Molecular Mechanisms by JEEVENDRA MARTYN, J. A, KANEKI, Masao, YASUHARA, Shingo

“…Obesity is a major cause of type 2 diabetes, clinically evidenced as hyperglycemia. The altered glucose homeostasis is caused by faulty signal transduction via…”
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Nonopioid GTS-21 Mitigates Burn Injury Pain in Rats by Decreasing Spinal Cord Inflammatory Responses by Zhou, Yinhui, Leung-Pitt, Yiuka, Deng, Hao, Ren, Yang, You, Zerong, Kem, William R., Shen, Shiqian, Zhang, Wei, Mao, Jianren, Martyn, J. A. Jeevendra

“…BACKGROUND:Burn injury (BI) pain consists of inflammatory and neuropathic components and activates microglia. Nicotinic alpha 7 acetylcholine receptors…”
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Fentanyl Clearance and Volume of Distribution Are Increased in Patients With Major Burns by Han, Taehyung, Harmatz, Jerold S., Greenblatt, David J., Martyn, J. A. Jeevendra

“…This study examined the pharmacokinetics of fentanyl in burned patients during the hyperdynamic phase. Twenty adults, aged 37 ± 2 years (mean ± SE), with 49 ±…”
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Anesthesia with Disuse Leads to Autophagy Up-regulation in the Skeletal Muscle by Kashiwagi, Aki, Hosokawa, Sachiko, Maeyama, Yoshihiro, Ueki, Ryusuke, Kaneki, Masao, Martyn, J A Jeevendra, Yasuhara, Shingo

“…It has been known that skeletal muscles show atrophic changes after prolonged sedation or general anesthesia. Whether these effects are due to anesthesia…”
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Propofol Clearance and Volume of Distribution Are Increased in Patients With Major Burns by Han, Tae-Hyung, Greenblatt, David J., Martyn, J. A. Jeevendra

“…Propofol pharmacokinetics were examined in 17 adults with major burns during the hyperdynamic convalescent phase. Eighteen nonburned surgical patients served…”
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Cannabinoid Receptor Type 1 Antagonist, AM251, Attenuates Mechanical Allodynia and Thermal Hyperalgesia after Burn Injury by Ueda, Masashi, Iwasaki, Hajime, Wang, Shuxing, Murata, Eri, Poon, K. Y Trudy, Mao, Jianren, Martyn, J. A Jeevendra

“…BACKGROUND:Burn injury causes nociceptive behaviors, and inflammation-related pathologic pain can lead to glial cell activation. This study tested the…”
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Prolonged therapy with the anticonvulsant carbamazepine leads to increased plasma clearance of fentanyl by Nozari, Ala, Akeju, Oluwaseun, Mirzakhani, Hooman, Eskandar, Emad, Ma, Zhijun, Hossain, MD Amin, Wang, Qingping, Greenblatt, David J., Martyn, J. A. Jeevendra

“…Objectives Fentanyl is a potent analgesic that accounts for an increasing number of overdose deaths in the United States. This study tested whether altered…”
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GTS-21 attenuates loss of body mass, muscle mass, and function in rats having systemic inflammation with and without disuse atrophy by Schaller, Stefan J., Nagashima, Michio, Schönfelder, Martin, Sasakawa, Tomoki, Schulz, Fabian, Khan, Mohammed A. S., Kem, William R., Schneider, Gerhard, Schlegel, Jürgen, Lewald, Heidrun, Blobner, Manfred, Jeevendra Martyn, J. A.

“…Muscle changes of critical illness are attributed to systemic inflammatory responses and disuse atrophy. GTS-21 (3-(2,4-dimethoxy-benzylidene)anabaseine), also…”
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