Search Results - "Martuza, R. L"

Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial by Markert, J M, Medlock, M D, Rabkin, S D, Gillespie, G Y, Todo, T, Hunter, W D, Palmer, C A, Feigenbaum, F, Tornatore, C, Tufaro, F, Martuza, R L

“…G207 is a conditionally replicating derivative of herpes simplex virus (HSV) type-1 strain F engineered with deletions of both gamma(1)34.5 loci and a lacZ…”
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Intracarotid delivery of oncolytic HSV vector G47Δ to metastatic breast cancer in the brain by LIU, R, MARTUZA, R. L, RABKIN, S. D

“…Delivery of viral vectors to tumors in the brain is a challenge, especially via systemic administration, which is key to targeting the invasive margins of…”
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Analysis of genetically engineered oncolytic herpes simplex viruses in human prostate cancer organotypic cultures by Passer, B J, Wu, C-l, Wu, S, Rabkin, S D, Martuza, R L

“…Oncolytic herpes simplex viruses type 1 (oHSVs) such as G47Δ and G207 are genetically engineered for selective replication competence in cancer cells. Several…”
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Oncolytic herpes simplex virus armed with xenogeneic homologue of prostatic acid phosphatase enhances antitumor efficacy in prostate cancer by Castelo-Branco, P, Passer, B J, Buhrman, J S, Antoszczyk, S, Marinelli, M, Zaupa, C, Rabkin, S D, Martuza, R L

“…Prostate cancer is one of the most prevalent cancers in men. Replication-competent oncolytic herpes simplex virus (oHSV) vectors are a powerful antitumor…”
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Enhanced therapeutic efficacy of IL-12, but not GM-CSF, expressing oncolytic herpes simplex virus for transgenic mouse derived prostate cancers by Varghese, S, Rabkin, S D, Liu, R, Nielsen, P G, Ipe, T, Martuza, R L

“…Replication competent oncolytic herpes simplex viruses (HSV) with broad-spectrum activity against various cancers, including prostate cancer, exert a dual…”
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Oncolytic herpes simplex virus vectors and taxanes synergize to promote killing of prostate cancer cells by Passer, B J, Castelo-Branco, P, Buhrman, J S, Varghese, S, Rabkin, S D, Martuza, R L

“…Genetically engineered oncolytic herpes simplex virus-1 (HSV-1) vectors selectively replicate in tumor cells causing direct killing whereas sparing normal…”
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Effect of prior exposure to herpes simplex virus 1 on viral vector-mediated tumor therapy in immunocompetent mice by CHAHLAVI, A, RABKIN, S. D, TODO, T, SUNDARESAN, P, MARTUZA, R. L

“…Replication-competent, attenuated mutants of herpes simplex virus type 1 (HSV-1) have been shown to be efficacious for tumor therapy. However, these studies…”
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Combination suicide/cytokine gene therapy as adjuvants to a defective herpes simplex virus-based cancer vaccine by TODA, M, MARTUZA, R. L, RABKIN, S. D

“…We have used syngeneic, established bilateral subcutaneous tumor models to examine the antitumor activity of herpes simplex virus (HSV) vectors, including the…”
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Systemic antitumor immunity in experimental brain tumor therapy using a multimutated, replication-competent herpes simplex virus by Todo, T, Rabkin, S D, Sundaresan, P, Wu, A, Meehan, K R, Herscowitz, H B, Martuza, R L

“…Replication-competent, attenuated herpes simplex virus (HSV) vectors have been developed for viral oncolytic therapy of primary and metastatic malignant brain…”
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Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells by Wakimoto, Hiroaki, Mohapatra, Gayatry, Kanai, Ryuichi, Curry, Jr, William T, Yip, Stephen, Nitta, Mai, Patel, Anoop P, Barnard, Zachary R, Stemmer-Rachamimov, Anat O, Louis, David N, Martuza, Robert L, Rabkin, Samuel D

“…The clinicopathological heterogeneity of glioblastoma (GBM) and the various genetic and phenotypic subtypes in GBM stem cells (GSCs) are well described…”
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Local and systemic therapy of human prostate adenocarcinoma with the conditionally replicating herpes simplex virus vector G207 by Walker, J R, McGeagh, K G, Sundaresan, P, Jorgensen, T J, Rabkin, S D, Martuza, R L

“…Prostate adenocarcinoma is the most common nonskin malignancy in males and the second most common cause of cancer death in the United States (Landis et al.,…”
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Hepatoma-specific antitumor activity of an albumin enhancer/promoter regulated herpes simplex virus in vivo by MIYATAKE, S.-I, TANI, S, RABKIN, S. D, FEIGENBAUM, F, SUNDARESAN, P, TODA, H, NARUMI, O, KIKUCHI, H, HASHIMOTO, N, HANGAI, M, MARTUZA, R. L

“…Targeting viral vectors to appropriate cell types so that normal cells are not adversely affected is an important goal for gene therapy. Previously, we…”
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Oncolytic viral therapies - the clinical experience by Aghi, Manish, Martuza, Robert L

“…It has been 9 years since the beginning of the first clinical trial in which an oncolytic virus was administered to cancer patients. Since then, oncolytic…”
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Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant by Martuza, Robert L., Malick, Amy, Markert, James M., Ruffner, Katherine L., Coen, Donald M.

“…Malignant gliomas are the most common malignant brain tumors and are almost always fatal. A thymidine kinase-negative mutant of herpes simplex virus-1 (dlsptk)…”
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Combination of vinblastine and oncolytic herpes simplex virus vector expressing IL-12 therapy increases antitumor and antiangiogenic effects in prostate cancer models by Passer, B J, Cheema, T, Wu, S, Wu, C-l, Rabkin, S D, Martuza, R L

“…Oncolytic herpes simplex virus (oHSV)-1-based vectors selectively replicate in tumor cells causing direct killing, that is, oncolysis, while sparing normal…”
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Association of epidermal growth factor receptor gene amplification with loss of chromosome 10 in human glioblastoma multiforme by VON DEIMLING, A, LOUIS, D. N, SEIZINGER, B. R, VON AMMON, K, PETERSEN, I, HOELL, T, CHUNG, R. Y, MARTUZA, R. L, SCHOENFELD, D. A, YASARGIL, G, WIESTLER, O. D

“…Although the loss of tumor suppressor genes and the activation of oncogenes have been established as two of the fundamental mechanisms of tumorigenesis in…”
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Neurofibromatosis 2 (bilateral acoustic neurofibromatosis) by Martuza, R L, Eldridge, R

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Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line by Short, M P, Choi, B C, Lee, J K, Malick, A, Breakefield, X O, Martuza, R L

“…Retrovirus vectors only integrate into the genome of dividing cells and can thus be used to selectively infect tumor cells in the adult rat brain. Gene…”
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Replication-selective virotherapy for cancer: Biological principles, risk management and future directions by Kirn, David, Martuza, Robert L, Zwiebel, James

“…In the search for novel cancer therapies that can be used in conjunction with existing treatments, one promising area of research is the use of viral vectors…”
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Treatment of human malignant meningiomas by G207, a replication-competent multimutated herpes simplex virus 1 by YASAKI, T, MANZ, H. J, RABKIN, S. D, MARTUZA, R. L

“…We have demonstrated that replication-competent attenuated mutants of herpes simplex virus type 1 (HSV-1) have therapeutic potential for malignant gliomas…”
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