Search Results - "Martuscello, Regina T."

Histopathology of the cerebellar cortex in essential tremor and other neurodegenerative motor disorders: comparative analysis of 320 brains by Louis, Elan D., Martuscello, Regina T., Gionco, John T., Hartstone, Whitney G., Musacchio, Jessica B., Portenti, Marisa, McCreary, Morgan, Kuo, Sheng-Han, Vonsattel, Jean-Paul G., Faust, Phyllis L.

“…In recent years, numerous morphologic changes have been identified in the essential tremor (ET) cerebellar cortex, distinguishing ET from control brains. These…”
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Contextualizing the pathology in the essential tremor cerebellar cortex: a patholog-omics approach by Louis, Elan D., Kerridge, Chloë A., Chatterjee, Debotri, Martuscello, Regina T., Diaz, Daniel Trujillo, Koeppen, Arnulf H., Kuo, Sheng-Han, Vonsattel, Jean-Paul G., Sims, Peter A., Faust, Phyllis L.

“…Several morphological changes, centered in/around Purkinje cells (PCs), have been identified in the cerebellum of essential tremor (ET) patients. These changes…”
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Constitutive activation of myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tissue invasion by Wong, Sophie Y, Ulrich, Theresa A, Deleyrolle, Loic P, MacKay, Joanna L, Lin, Jung-Ming G, Martuscello, Regina T, Jundi, Musa A, Reynolds, Brent A, Kumar, Sanjay

“…Tumor-initiating cells (TIC) perpetuate tumor growth, enable therapeutic resistance, and drive initiation of successive tumors. Virtually nothing is known…”
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Defective cerebellar ryanodine receptor type 1 and endoplasmic reticulum calcium ‘leak’ in tremor pathophysiology by Martuscello, Regina T., Chen, Meng-Ling, Reiken, Steven, Sittenfeld, Leah R., Ruff, David S., Ni, Chun-Lun, Lin, Chih-Chun, Pan, Ming-Kai, Louis, Elan D., Marks, Andrew R., Kuo, Sheng-Han, Faust, Phyllis L.

“…Essential Tremor (ET) is a prevalent neurological disease characterized by an 8–10 Hz action tremor. Molecular mechanisms of ET remain poorly understood…”
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Gene expression analysis of the cerebellar cortex in essential tremor by Martuscello, Regina T., Kerridge, Chloë A., Chatterjee, Debotri, Hartstone, Whitney G., Kuo, Sheng-Han, Sims, Peter A., Louis, Elan D., Faust, Phyllis L.

“…•Essential tremor (ET) is one of the most common neurological diseases.•The underlying molecular mechanisms are not clear.•Our goal was to explore the…”
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PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide by Hoang-Minh, Lan B, Deleyrolle, Loic P, Nakamura, Nariaki S, Parker, Alexander K, Martuscello, Regina T, Reynolds, Brent A, Sarkisian, Matthew R

“…Abstract A better understanding of the molecules implicated in the growth and survival of glioblastoma (GBM) cells and their response to temozolomide (TMZ),…”
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Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms by Martuscello, Regina T., Spengler, Robert N., Bonoiu, Adela C., Davidson, Bruce A., Helinski, Jadwiga, Ding, Hong, Mahajan, Supriya, Kumar, Rajiv, Bergey, Earl J., Knight, Paul R., Prasad, Paras N., Ignatowski, Tracey A.

“…Increasing only the expression of the pleiotropic cytokine tumor necrosis factor–alpha exclusively in the hippocampus of naïve rats induces peripheral…”
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A Supplemented High-Fat Low-Carbohydrate Diet for the Treatment of Glioblastoma by Martuscello, Regina T, Vedam-Mai, Vinata, McCarthy, David J, Schmoll, Michael E, Jundi, Musa A, Louviere, Christopher D, Griffith, Benjamin G, Skinner, Colby L, Suslov, Oleg, Deleyrolle, Loic P, Reynolds, Brent A

“…Dysregulated energetics coupled with uncontrolled proliferation has become a hallmark of cancer, leading to increased interest in metabolic therapies…”
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Essential Tremor versus “ET-plus”: A Detailed Postmortem Study of Cerebellar Pathology by Gionco, John T., Hartstone, Whitney G., Martuscello, Regina T., Kuo, Sheng-Han, Faust, Phyllis L., Louis, Elan D.

“…Essential tremor (ET) is among the most prevalent movement disorders, and by some accounts, the most common form of cerebellar degeneration. Over the past…”
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Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1 by Tejwani, Leon, Ravindra, Neal G, Lee, Changwoo, Cheng, Yubao, Nguyen, Billy, Luttik, Kimberly, Ni, Luhan, Zhang, Shupei, Morrison, Logan M, Gionco, John, Xiang, Yangfei, Yoon, Jennifer, Ro, Hannah, Haidery, Fatema, Grijalva, Rosalie M, Bae, Eunwoo, Kim, Kristen, Martuscello, Regina T, Orr, Harry T, Zoghbi, Huda Y, McLoughlin, Hayley S, Ranum, Laura P W, Shakkottai, Vikram G, Faust, Phyllis L, Wang, Siyuan, van Dijk, David, Lim, Janghoo

“…Neurodegeneration is a protracted process involving progressive changes in myriad cell types that ultimately results in the death of vulnerable neuronal…”
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Gene Expression Analysis of Laser-Captured Purkinje Cells in the Essential Tremor Cerebellum by Martuscello, Regina T., Sivaprakasam, Karthigayini, Hartstone, Whitney, Kuo, Sheng-Han, Konopka, Genevieve, Louis, Elan D., Faust, Phyllis L.

“…Essential tremor (ET) is a common, progressive neurological disease characterized by an 8–12-Hz kinetic tremor. Despite its high prevalence, the…”
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A Stainless Protocol for High Quality RNA Isolation from Laser Capture Microdissected Purkinje Cells in the Human Post-Mortem Cerebellum by Martuscello, Regina T, Louis, Elan D, Faust, Phyllis L

“…Laser capture microdissection (LCM) is an advantageous tool that allows for the collection of cytologically and/or phenotypically relevant cells or regions…”
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TM-13DIMINISHED PROGRESSION OF GLIOBLASTOMA WITH A SUPPLEMENTED HIGH-FAT LOW-CARBOHYDRATE DIET by Martuscello, Regina T., Deleyrolle, Loic P., Louviere, Christopher D., McCarthy, David J., Skinner, Colby L., Jundi, Musa A., Reynolds, Brent A.

“…Glioblastoma [GB] is the deadliest and most malignant type of brain tumor, with a median survival less than 12 months. Research into tumor metabolism and the…”
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TM-13 DIMINISHED PROGRESSION OF GLIOBLASTOMA WITH A SUPPLEMENTED HIGH-FAT LOW-CARBOHYDRATE DIET by Martuscello, R. T., Deleyrolle, L. P., Louviere, C. D., McCarthy, D. J., Skinner, C. L., Jundi, M. A., Reynolds, B. A.

“…Glioblastoma [GB] is the deadliest and most malignant type of brain tumor, with a median survival less than 12 months. Research into tumor metabolism and the…”
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PCM1 Depletion Inhibits Glioblastoma Cell Ciliogenesis and Increases Cell Death and Sensitivity to Temozolomide1 by Hoang-Minh, Lan B., Deleyrolle, Loic P., Nakamura, Nariaki S., Parker, Alexander K., Martuscello, Regina T., Reynolds, Brent A., Sarkisian, Matthew R.

“…A better understanding of the molecules implicated in the growth and survival of glioblastoma (GBM) cells and their response to temozolomide (TMZ), the…”
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