Search Results - "Martus, HansJoerg"
-
1
Pig-a gene mutation assay study design: critical assessment of 3- versus 28-day repeat-dose treatment schedules
Published in Mutagenesis (01-07-2020)“…Abstract The in vivo Pig-a assay is being used in safety studies to evaluate the potential of chemicals to induce somatic cell gene mutations. Ongoing work is…”
Get full text
Journal Article -
2
Improving the Assessment of Risk Factors Relevant to Potential Carcinogenicity of Gene Therapies: A Consensus Article
Published in Human gene therapy (01-08-2024)“…Regulators and industry are actively seeking improvements and alternatives to current models and approaches to evaluate potential carcinogenicity of gene…”
Get more information
Journal Article -
3
Intra‐ and inter‐laboratory reproducibility of the rat blood Pig‐a gene mutation assay
Published in Environmental and molecular mutagenesis (01-06-2020)“…The in vivo Pig‐a assay is being used in safety studies to evaluate the potential of chemicals to induce somatic cell gene mutations. Ongoing work is aimed at…”
Get full text
Journal Article -
4
Miniaturized flow cytometry-based in vitro primary human lymphocyte micronucleus assay-validation study
Published in Environmental and molecular mutagenesis (01-05-2012)“…Most in vitro mammalian genotoxicity assays show a low specificity (high rate of irrelevant positive results), and therefore, lead to an increase in follow‐up…”
Get full text
Journal Article -
5
Methylphenidate is not clastogenic in cultured human lymphocytes and in the mouse bone-marrow micronucleus test
Published in Mutation research (05-09-2006)“…Methylphenidate (MPH) is one of the most frequently prescribed drugs for the treatment of attention deficit hyperactivity disorder (ADHD). A report on…”
Get full text
Journal Article