Search Results - "Marttila, T."

Protective coatings of electronics under harsh thermal shock by Pippola, J., Marttila, T., Frisk, L.

“…Industrial electronics devices commonly encounter harsh environmental conditions during their operational lifetime. To protect the electronics from conditions…”
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682: Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomas by Li, J, Bonifati, S, Hristov, G, Marttila, T, Rommelaere, J, Marchini, A

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Toxicity in patients receiving adjuvant docetaxel + hormonal treatment after radical radiotherapy for intermediate or high-risk prostate cancer: a preplanned safety report of the SPCG-13 trial by Kellokumpu-Lehtinen, P-L, Hjälm-Eriksson, M, Thellenberg-Karlsson, C, Åström, L, Franzen, L, Marttila, T, Seke, M, Taalikka, M, Ginman, C

“…Background: Radical radiotherapy (RT) combined with androgen deprivation therapy is currently the standard treatment for elderly patients with localized…”
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SHOX triggers the lysosomal pathway of apoptosis via oxidative stress by Hristov, G., Marttila, T., Durand, C., Niesler, B., Rappold, G. A., Marchini, A.

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Rational Design of an Active Avidin Monomer by Laitinen, Olli H., Nordlund, Henri R., Hytönen, Vesa P., Uotila, Sanna T.H., Marttila, Ari T., Savolainen, Janne, Airenne, Kari J., Livnah, Oded, Bayer, Edward A., Wilchek, Meir, Kulomaa, Markku S.

“…Homotetrameric chicken avidin that binds four molecules of biotin was converted to a monomeric form (monoavidin) by mutations of two interface residues:…”
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Enhanced Gene Delivery by Avidin-Displaying Baculovirus by Räty, Jani K, Airenne, Kari J, Marttila, Ari T, Marjomäki, Varpu, Hytönen, Vesa P, Lehtolainen, Pauliina, Laitinen, Olli H, Mähönen, Anssi J, Kulomaa, Markku S, Ylä-Herttuala, Seppo

“…Flexible alteration of virus surface properties would be beneficial for enhanced and targeted gene delivery. A useful approach could be based on a…”
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Mutation of the important Tyr-33 residue of chicken avidin: functional and structural consequences by Marttila, Ari T, Hytönen, Vesa P, Laitinen, Olli H, Bayer, Edward A, Wilchek, Meir, Kulomaa, Markku S

“…The strong interaction between avidin and biotin is so tight (dissociation constant 10(-15) M) that conditions usually sufficient for protein denaturing fail…”
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Mutation of a critical tryptophan to lysine in avidin or streptavidin may explain why sea urchin fibropellin adopts an avidin-like domain by Laitinen, Olli H., Airenne, Kari J., Marttila, Ari T., Kulik, Tikva, Porkka, Eevaleena, Bayer, Edward A., Wilchek, Meir, Kulomaa, Markku S.

“…Sea urchin fibropellins are epidermal growth factor homologues that harbor a C-terminal domain, similar in sequence to hen egg-white avidin and bacterial…”
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Initiators in processes leading to hearing loss identification in Finnish children by MARTTILA, T. I, KARIKOSKI, J. O

“…The objective was to examine processes leading to the diagnosis of hearing loss in children. The subjects were 328 children (hearing loss >30 dB HL) fitted…”
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Characterization of poultry egg-white avidins and their potential as a tool in pretargeting cancer treatment by Hytönen, Vesa P, Laitinen, Olli H, Grapputo, Alessandro, Kettunen, Anu, Savolainen, Janne, Kalkkinen, Nisse, Marttila, Ari T, Nordlund, Henri R, Nyholm, Thomas K M, Paganelli, Giovanni, Kulomaa, Markku S

“…Chicken avidin and bacterial streptavidin are proteins used in a wide variety of applications in the life sciences due to their strong affinity for biotin. A…”
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Recombinant NeutraLite Avidin: a non-glycosylated, acidic mutant of chicken avidin that exhibits high affinity for biotin and low non-specific binding properties by Marttila, Ari T., Laitinen, Olli H., Airenne, Kari J., Kulik, Tikva, Bayer, Edward A., Wilchek, Meir, Kulomaa, Markku S.

“…A recombinant non-glycosylated and acidic form of avidin was designed and expressed in soluble form in baculovirus-infected insect cells. The mutations were…”
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Engineering of chicken avidin: a progressive series of reduced charge mutants by Marttila, Ari T, Airenne, Kari J, Laitinen, Olli H, Kulik, Tikva, Bayer, Edward A, Wilchek, Meir, Kulomaa, Markku S

“…Avidin, a positively charged egg-white glycoprotein, is a widely used tool in biotechnological applications because of its ability to bind biotin strongly. The…”
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Dual-affinity avidin molecules by Hytönen, Vesa P., Nordlund, Henri R., Hörhä, Jarno, Nyholm, Thomas K. M., Hyre, David E., Kulomaa, Tuomas, Porkka, Eevaleena J., Marttila, Ari T., Stayton, Patrick S., Laitinen, Olli H., Kulomaa, Markku S.

“…A recently reported dual‐chain avidin was modified further to contain two distinct, independent types of ligand‐binding sites within a single polypeptide…”
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Role of transtympanic endoscopy of the middle ear in the diagnosis of perilymphatic fistula in patients with sensorineural hearing loss or vertigo by Selmani, Z, Pyykkö, I, Ishizaki, H, Marttila, T I

“…The diagnosis of perilymphatic fistula (PLF) is often difficult, and therefore the condition can be overlooked. Tympanoscopy presents an alternative procedure…”
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Human complement factor H related protein test for monitoring bladder cancer by Raitanen, M P, Marttila, T, Nurmi, M, Ala-Opas, M, Nieminen, P, Aine, R, Tammela, T L

“…The BTA stat test is a rapid, noninvasive, qualitative urine test that detects bladder tumor associated antigen (human complement factor H related protein) in…”
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Biotin induces tetramerization of a recombinant monomeric avidin. A model for protein-protein interactions by Laitinen, O H, Marttila, A T, Airenne, K J, Kulik, T, Livnah, O, Bayer, E A, Wilchek, M, Kulomaa, M S

“…Chicken avidin, a homotetramer that binds four molecules of biotin was converted to a monomeric form by successive mutations of interface residues to alanine…”
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Chicken avidin-related proteins show altered biotin-binding and physico-chemical properties as compared with avidin by Laitinen, Olli H, Hytönen, Vesa P, Ahlroth, Mervi K, Pentikäinen, Olli T, Gallagher, Ciara, Nordlund, Henri R, Ovod, Vladimir, Marttila, Ari T, Porkka, Eevaleena, Heino, Sanna, Johnson, Mark S, Airenne, Kari J, Kulomaa, Markku S

“…Chicken avidin and bacterial streptavidin are proteins familiar from their use in various (strept)avidin-biotin technological applications. Avidin binds the…”
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Cochlear blood flow measurement in patients with Ménière's disease and other inner ear disorders by Selmani, Z, Pyykkö, I, Ishizaki, H, Marttila, T I

“…To identify an eventual vascular aetiology in different diseases with sensorineural hearing loss (SNHL), the cochlear blood flow (CoBF) was measured using…”
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Effect of intravesical instillations on the human complement factor H related protein (BTA stat) test by Raitanen, M P, Hellström, P, Marttila, T, Korhonen, H, Talja, M, Ervasti, J, Tammela, T L

“…The BTA stat is a rapid, non-invasive, qualitative urine test that detects bladder tumor-associated antigen (human complement factor H related protein) in…”
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205 Intravesical Bacillus Calmette-Guérin (BCG) versus combination of epirubicin and interferon-α2a (EPI+INF) instillations in prevention of frequently recurrent non-muscle-invasive bladder carcinoma (NMIBC) - FinnBladder-6 study by Marttila, T, Järvinen, R, Seppänen, M, Liukkonen, T, Raitanen, M, Boström, P, Kaasinen, E

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