Search Results - "Martoriati, Alain"

Synthesis and Biological Activity of a New Indenoisoquinoline Copper Derivative as a Topoisomerase I Inhibitor by Molinaro, Caroline, Wambang, Nathalie, Pellegrini, Sylvain, Henry, Natacha, Lensink, Marc F., Germain, Emmanuelle, Bousquet, Till, de Ruyck, Jérôme, Cailliau, Katia, Pélinski, Lydie, Martoriati, Alain

“…Topoisomerases are interesting targets in cancer chemotherapy. Here, we describe the design and synthesis of a novel copper(II) indenoisoquinoline complex,…”
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A Novel Copper(II) Indenoisoquinoline Complex Inhibits Topoisomerase I, Induces G2 Phase Arrest, and Autophagy in Three Adenocarcinomas by Molinaro, Caroline, Wambang, Nathalie, Bousquet, Till, Vercoutter-Edouart, Anne-Sophie, Pélinski, Lydie, Cailliau, Katia, Martoriati, Alain

“…Topoisomerases, targets of inhibitors used in chemotherapy, induce DNA breaks accumulation leading to cancer cell death. A newly synthesized copper(II)…”
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Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation by Drouyer, Matthieu, Bolliger, Marc F., Lobbestael, Evy, Van den Haute, Chris, Emanuele, Marco, Lefebvre, Réginald, Sibran, William, De Wit, Tina, Leghay, Coline, Mutez, Eugénie, Dzamko, Nicolas, Halliday, Glenda M., Murayama, Shigeo, Martoriati, Alain, Cailliau, Katia, Bodart, Jean-François, Chartier-Harlin, Marie-Christine, Baekelandt, Veerle, Nichols, R. Jeremy, Taymans, Jean-Marc

“…LRRK2 is a highly phosphorylated multidomain protein and mutations in the gene encoding LRRK2 are a major genetic determinant of Parkinson's disease (PD)…”
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Inhibition of mitochondrial respiration mediates apoptosis induced by the anti-tumoral alkaloid lamellarin D by Ballot, Caroline, Kluza, Jérome, Lancel, Steve, Martoriati, Alain, Hassoun, Sidi Mohamed, Mortier, Laurent, Vienne, Jean-Claude, Briand, Gilbert, Formstecher, Pierre, Bailly, Christian, Nevière, Remi, Marchetti, Philippe

“…Lamellarin D (Lam D), a marine alkaloid, exhibits a potent cytotoxicity against many different tumors. The pro-apoptotic function of Lam D has been attributed…”
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Effects of Ferrocenyl 4-(Imino)-1,4-Dihydro-quinolines on Xenopus laevis Prophase I - Arrested Oocytes: Survival and Hormonal-Induced M-Phase Entry by Marchand, Guillaume, Wambang, Nathalie, Pellegrini, Sylvain, Molinaro, Caroline, Martoriati, Alain, Bousquet, Till, Markey, Angel, Lescuyer-Rousseau, Arlette, Bodart, Jean-François, Cailliau, Katia, Pelinski, Lydie, Marin, Matthieu

“…oocytes were used as cellular and molecular sentinels to assess the effects of a new class of organometallic compounds called ferrocenyl dihydroquinolines that…”
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Another facet to the anticancer response to lamellarin D: induction of cellular senescence through inhibition of topoisomerase I and intracellular Ros production by Ballot, Caroline, Martoriati, Alain, Jendoubi, Manel, Buche, Sébastien, Formstecher, Pierre, Mortier, Laurent, Kluza, Jérome, Marchetti, Philippe

“…Lamellarin D (LamD) is a marine alkaloid with broad spectrum antitumor activities. Multiple intracellular targets of LamD, which affect cancer cell growth and…”
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Diversity of sialic acids and sialoglycoproteins in gametes and at fertilization by Fliniaux, Ingrid, Marchand, Guillaume, Molinaro, Caroline, Decloquement, Mathieu, Martoriati, Alain, Marin, Matthieu, Bodart, Jean-François, Harduin-Lepers, Anne, Cailliau, Katia

“…Sialic acids are a family of 9-carbon monosaccharides with particular physicochemical properties. They modulate the biological functions of the molecules that…”
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Characterization of a Protein Phosphatase Type-1 and a Kinase Anchoring Protein in Plasmodium falciparum by Lenne, Astrid, De Witte, Caroline, Tellier, Géraldine, Hollin, Thomas, Aliouat, El Moukhtar, Martoriati, Alain, Cailliau, Katia, Saliou, Jean-Michel, Khalife, Jamal, Pierrot, Christine

“…With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a central role in many functions of the biology of eukaryotic…”
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Plasmodium berghei leucine-rich repeat protein 1 downregulates protein phosphatase 1 activity and is required for efficient oocyst development by Fréville, Aline, Gnangnon, Bénédicte, Tremp, Annie Z, De Witte, Caroline, Cailliau, Katia, Martoriati, Alain, Aliouat, El Moukthar, Fernandes, Priyanka, Chhuon, Cerina, Silvie, Olivier, Marion, Sabrina, Guerrera, Ida Chiara, Dessens, Johannes T, Pierrot, Christine, Khalife, Jamal

“…Protein phosphatase 1 (PP1) is a key enzyme for development. However, the detailed mechanisms underlying its regulation remain to be deciphered. Here, we…”
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Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D by Ballot, Caroline, Kluza, Jérome, Martoriati, Alain, Nyman, Ulrika, Formstecher, Pierre, Joseph, Bertrand, Bailly, Christian, Marchetti, Philippe

“…Lamellarin D, a potent cytotoxic marine alkaloid, exerts its antitumor action through two complementary pathways: a nuclear route via topoisomerase I…”
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Hydrogen Sulfide Impairs Meiosis Resumption in Xenopus laevis Oocytes by Gelaude, Armance, Slaby, Sylvain, Cailliau, Katia, Marin, Matthieu, Lescuyer-Rousseau, Arlette, Molinaro, Caroline, Nevoral, Jan, Kučerová-Chrpová, Veronica, Sedmikova, Marketa, Petr, Jaroslav, Martoriati, Alain, Bodart, Jean-François

“…The role of hydrogen sulfide (H S) is addressed in oocytes. Three enzymes involved in H S metabolism, cystathionine β-synthase, cystathionine γ-lyase, and…”
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Nitric oxide-donor SNAP induces Xenopus eggs activation by Jeseta, Michal, Marin, Matthieu, Tichovska, Hana, Melicharova, Petra, Cailliau-Maggio, Katia, Martoriati, Alain, Lescuyer-Rousseau, Arlette, Beaujois, Rémy, Petr, Jaroslav, Sedmikova, Marketa, Bodart, Jean-François

“…Nitric oxide (NO) is identified as a signaling molecule involved in many cellular or physiological functions including meiotic maturation and parthenogenetic…”
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Effect of Growth Hormone (GH) on In Vitro Nuclear and Cytoplasmic Oocyte Maturation, Cumulus Expansion, Hyaluronan Synthases, and Connexins 32 and 43 Expression, and GH Receptor Messenger RNA Expression in Equine and Porcine Species by MARCHAL, Réjane, CAILLAUD, Maud, MARTORIATI, Alain, GERARD, Nadine, MERMILLOD, Pascal, GOUDET, Ghylène

“…The aim of this study was to investigate the role of growth hormone (GH) on in vitro cumulus expansion and oocyte maturation in equine and porcine…”
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Interleukin-1 (IL-1) system gene expression in granulosa cells: kinetics during terminal preovulatory follicle maturation in the mare by Martoriati, Alain, Gérard, Nadine

“…A growing body of evidences suggests that the ovary is a site of inflammatory reactions, and thus, ovarian cells could represent sources and targets of the…”
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Copper Complexes as Anticancer Agents Targeting Topoisomerases I and II by Molinaro, Caroline, Martoriati, Alain, Pelinski, Lydie, Cailliau, Katia

“…Organometallics, such as copper compounds, are cancer chemotherapeutics used alone or in combination with other drugs. One small group of copper complexes…”
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PTPRV is a Key Mediator of p53-Induced Cell Cycle Exit by Doumont, Gilles, Martoriati, Alain, Marine, Jean-Christophe

“…The p53 tumor suppressor functions as a sequence-specific DNA-binding transcription factor that promotes antiproliferative responses, including cell cycle…”
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Cumulus expansion, nuclear maturation and connexin 43, cyclooxygenase-2 and FSH receptor mRNA expression in equine cumulus-oocyte complexes cultured in vitro in the presence of FSH and precursors for hyaluronic acid synthesis by Dell'Aquila, Maria Elena, Caillaud, Maud, Maritato, Filippo, Martoriati, Alain, Gérard, Nadine, Aiudi, Giulio, Minoia, Paolo, Goudet, Ghylène

“…The aim of this study was to investigate cumulus expansion, nuclear maturation and expression of connexin 43, cyclooxygenase-2 and FSH receptor transcripts in…”
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dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53 by MARTORIATI, Alain, DOUMONT, Gilles, ALCALAY, Myriam, BELLEFROID, Eric, PELICCI, Pier Giuseppe, MARINE, Jean-Christophe

“…The p53 tumour suppressor functions as a transcriptional activator, and several p53-inducible genes that play a critical proapoptotic role have been described…”
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Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies by Molinaro, Caroline, Martoriati, Alain, Cailliau, Katia

“…Cells respond to genotoxic stress through a series of complex protein pathways called DNA damage response (DDR). These monitoring mechanisms ensure the…”
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3‐phosphoinositide‐dependent protein kinase 1 (PDK1) mediates crosstalk between Src and Akt pathways in MET receptor signaling by Molinaro, Caroline, Martoriati, Alain, Lescuyer, Arlette, Fliniaux, Ingrid, Tulasne, David, Cailliau, Katia

“…The high‐affinity tyrosine kinase receptor MET plays a pivotal role in several facets of cell regulation. Although its mitogenic effect is well documented,…”
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