Kinetics of rabies antibodies as a strategy for canine active immunization

Kinetics of rabies antibodies as a strategy for canine active immunization

Rabies, a zoonosis found throughout the globe, is caused by a virus of the Lyssavirus genus. The disease is transmitted to humans through the inoculation of the virus present in the saliva of infected mammals. Since its prognosis is usually fatal for humans, nationwide public campaigns to vaccinate...

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Bibliographic Details
Published in:The journal of venomous animals and toxins including tropical diseases Vol. 20; no. 1; p. 37
Main Authors: Babboni, Selene Daniela, da Costa, Hení Falcão, Martorelli, Luzia de Fátima Alves, Kataoka, Ana Paula de Arruda Geraldes, Victoria, Cassiano, Padovani, Carlos Roberto, Modolo, José Rafael
Format: Journal Article
Language:English
Published: Brazil BioMed Central Ltd 26-08-2014
BioMed Central
Centro de Estudos de Venenos e Animais Peçonhentos
SciELO
Subjects:
Annual vaccination campaign
Disease transmission
Dogs
Epidemiology
Fuenzalida-Palácios
Measurement
Methods
Pneumoviridae
Prevention
Prognosis
Rabies
Revaccination
Short Report
TOXICOLOGY
TROPICAL MEDICINE
Vaccination
Annual vaccination campaign
Revaccination
Rabies
Vaccination
Fuenzalida-Palácios
Dogs
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Summary:Rabies, a zoonosis found throughout the globe, is caused by a virus of the Lyssavirus genus. The disease is transmitted to humans through the inoculation of the virus present in the saliva of infected mammals. Since its prognosis is usually fatal for humans, nationwide public campaigns to vaccinate dogs and cats against rabies aim to break the epidemiological link between the virus and its reservoirs in Brazil. During 12 months we evaluated the active immunity of dogs first vaccinated (booster shot at 30 days after first vaccination) against rabies using the Fuenzalida-Palácios modified vaccine in the urban area of Botucatu city, São Pauto state, Brazil. Of the analyzed dogs, 54.7% maintained protective titers (≥0.5 IU/mL) for 360 days after the first vaccination whereas 51.5% during all the study period. The present results suggest a new vaccination schedule for dogs that have never been vaccinated. In addition to the first dose of vaccine, two others are recommended: the second at 30 days after the first and the third dose at 180 days after the first for the maintenance of protective titers during 12 months.
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ISSN:1678-9199
1678-9180
1678-9199
DOI:10.1186/1678-9199-20-37