Search Results - "Marton, Matthew J."

Concordance between single-nucleotide polymorphism-based genomic instability assays and a next-generation sequencing-based homologous recombination deficiency test by Cristescu, Razvan, Liu, Xiao Qiao, Arreaza, Gladys, Chen, Cai, Albright, Andrew, Qiu, Ping, Marton, Matthew J

“…We evaluated the performance of single-nucleotide polymorphism (SNP) genotyping arrays OncoScan (Thermo Fisher Scientific, San Diego, CA) and Infinium…”
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Navigating the rapids: the development of regulated next-generation sequencing-based clinical trial assays and companion diagnostics by Pant, Saumya, Weiner, Russell, Marton, Matthew J

“…Over the past decade, next-generation sequencing (NGS) technology has experienced meteoric growth in the aspects of platform, technology, and supporting…”
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Pre-Analytical Considerations for Successful Next-Generation Sequencing (NGS): Challenges and Opportunities for Formalin-Fixed and Paraffin-Embedded Tumor Tissue (FFPE) Samples by Arreaza, Gladys, Qiu, Ping, Pang, Ling, Albright, Andrew, Hong, Lewis Z, Marton, Matthew J, Levitan, Diane

“…In cancer drug discovery, it is important to investigate the genetic determinants of response or resistance to cancer therapy as well as factors that…”
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HCV genotyping from NGS short reads and its application in genotype detection from HCV mixed infected plasma by Qiu, Ping, Stevens, Richard, Wei, Bo, Lahser, Fred, Howe, Anita Y M, Klappenbach, Joel A, Marton, Matthew J

“…Genotyping of hepatitis C virus (HCV) plays an important role in the treatment of HCV. As new genotype-specific treatment options become available, it has…”
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Data Interoperability of Whole Exome Sequencing (WES) Based Mutational Burden Estimates from Different Laboratories by Qiu, Ping, Pang, Ling, Arreaza, Gladys, Maguire, Maureen, Chang, Ken C N, Marton, Matthew J, Levitan, Diane

“…Immune checkpoint inhibitors, which unleash a patient's own T cells to kill tumors, are revolutionizing cancer treatment. Several independent studies suggest…”
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Analytical Validation of AmpliChip p53 Research Test for Archival Human Ovarian FFPE Sections by Marton, Matthew J, McNamara, Andrew R, Nikoloff, D Michele, Nakao, Aki, Cheng, Jonathan

“…The p53 tumor suppressor gene (TP53) is reported to be mutated in nearly half of all tumors and plays a central role in genome integrity. Detection of…”
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Association of programmed death ligand 1 expression with prognosis among patients with ten uncommon advanced cancers by Steiniche, Torben, Ladekarl, Morten, Georgsen, Jeanette Bæhr, Andreasen, Simon, Busch-Sørensen, Michael, Zhou, Wei, Marton, Matthew J, Pruitt, Scott K, Jin, Fan, Liaw, Kai-Li

“…PD-L1 expression and high levels of microsatellite instability (MSI-H) may predict response to checkpoint inhibitors, but their prevalence and prognostic value…”
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Prognostic significance of T‐cell–inflamed gene expression profile and PD‐L1 expression in patients with esophageal cancer by Steiniche, Torben, Rha, Sun Young, Chung, Hyun Cheol, Georgsen, Jeanette Baehr, Ladekarl, Morten, Nordsmark, Marianne, Jespersen, Marie Louise, Kim, Hyo Song, Kim, Hyunki, Fein, Carly, Tang, Laura H., Wu, Ting, Marton, Matthew J., Peter, Senaka, Kelsen, David P., Ku, Geoffrey

“…Purpose The ability of the T‐cell–inflamed gene expression profile (GEP) to predict clinical outcome in esophageal cancer (EC) is unknown. This retrospective…”
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Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles by Roberts, Christopher J., Nelson, Bryce, Marton, Matthew J., Stoughton, Roland, Meyer, Michael R., Bennett, Holly A., He, Yudong D., Dai, Hongyue, Walker, Wynn L., Hughes, Timothy R., Tyers, Mike, Boone, Charles, Friend, Stephen H.

“…Genome-wide transcript profiling was used to monitor signal transduction during yeast pheromone response. Genetic manipulations allowed analysis of changes in…”
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Development and validation of a clinical trial patient stratification assay that interrogates 27 mutation sites in MAPK pathway genes by Chang, Ken C N, Galuska, Stefan, Weiner, Russell, Marton, Matthew J

“…Somatic mutations identified on genes related to the cancer-developing signaling pathways have drawn attention in the field of personalized medicine in recent…”
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Effects of Atmospheric Ozone on Microarray Data Quality by Fare, Thomas L, Coffey, Ernest M, Dai, Hongyue, He, Yudong D, Kessler, Deborah A, Kilian, Kristopher A, Koch, John E, LeProust, Eric, Marton, Matthew J, Meyer, Michael R, Stoughton, Roland B, Tokiwa, George Y, Wang, Yanqun

“…A data anomaly was observed that affected the uniformity and reproducibility of fluorescent signal across DNA microarrays. Results from experimental sets…”
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Homologous Recombination Deficiency: Concepts, Definitions, and Assays by Stewart, Mark D, Merino Vega, Diana, Arend, Rebecca C, Baden, Jonathan F, Barbash, Olena, Beaubier, Nike, Collins, Grace, French, Tim, Ghahramani, Negar, Hinson, Patsy, Jelinic, Petar, Marton, Matthew J, McGregor, Kimberly, Parsons, Jerod, Ramamurthy, Lakshman, Sausen, Mark, Sokol, Ethan S, Stenzinger, Albrecht, Stires, Hillary, Timms, Kirsten M, Turco, Diana, Wang, Iris, Williams, J Andrew, Wong-Ho, Elaine, Allen, Jeff

“…Homologous recombination deficiency (HRD) is a phenotype that is characterized by the inability of a cell to effectively repair DNA double-strand breaks using…”
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Measuring Tumor Mutational Burden (TMB) in Plasma from mCRPC Patients Using Two Commercial NGS Assays by Qiu, Ping, Poehlein, Christian H., Marton, Matthew J., Laterza, Omar F., Levitan, Diane

“…Tumor tissue mutational burden (TMB) has emerged as a promising predictive biomarker for immune checkpoint therapy. Measuring TMB from circulating tumor DNA…”
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Concordance between an FDA-approved companion diagnostic and an alternative assay kit for assessing homologous recombination deficiency in ovarian cancer by Wehn, Amy K., Qiu, Ping, Lunceford, Jared, Yarunin, Alexander, Cristescu, Razvan, Liu, Li, Roessler, Kyria, Bilke, Sven, Day, John R., Timms, Kirsten M., Weichert, Wilko, Marton, Matthew J.

“…Authors evaluated the performance of a commercially available next-generation sequencing assay kit; this was based on genomic content from Illumina's TruSight™…”
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Functional Interactions between Yeast Translation Eukaryotic Elongation Factor (eEF) 1A and eEF3 by Anand, Monika, Chakraburtty, Kalpana, Marton, Matthew J, Hinnebusch, Alan G, Kinzy, Terri Goss

“…The translation elongation machinery in fungi differs from other eukaryotes in its dependence upon eukaryotic elongation factor 3 (eEF3). eEF3 is essential in…”
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cDNA targets improve whole blood gene expression profiling and enhance detection of pharmocodynamic biomarkers: a quantitative platform analysis by Parrish, Mark L, Wright, Chris, Rivers, Yarek, Argilla, David, Collins, Heather, Leeson, Brendan, Loboda, Andrey, Nebozhyn, Michael, Marton, Matthew J, Lejnine, Serguei

“…Genome-wide gene expression profiling of whole blood is an attractive method for discovery of biomarkers due to its non-invasiveness, simple clinical site…”
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Practical Guidance for Implementing Predictive Biomarkers into Early Phase Clinical Studies by Marton, Matthew J., Weiner, Russell

“…The recent U.S. Food and Drug Administration (FDA) coapprovals of several therapeutic compounds and their companion diagnostic devices (FDA News Release, 2011,…”
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T cell-inflamed gene expression profile and PD-L1 expression and pembrolizumab efficacy in advanced esophageal cancer by Shah, Manish A, Kojima, Takashi, Hochhauser, Daniel, Enzinger, Peter, Raimbourg, Judith, Hollebecque, Antoine, Lordick, Florian, Kim, Sung-Bae, Tajika, Masahiro, Lockhart, Albert Craig, Arkenau, Hendrick-Tobias, El-Hajbi, Farid, Gupta, Mukul, Pfeiffer, Per, Bhagia, Pooja, Cao, Zhu Alexander, Lunceford, Jared, Suryawanshi, Shailaja, Ayers, Mark, J Marton, Matthew, Kato, Ken

“…Investigate the relationship between response to pembrolizumab and expression of the 18-gene T cell-inflamed gene expression profile (Tcell GEP) or PD-L1…”
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A Gene-Expression Signature as a Predictor of Survival in Breast Cancer by van de Vijver, Marc J, He, Yudong D, van 't Veer, Laura J, Dai, Hongyue, Hart, Augustinus A.M, Voskuil, Dorien W, Schreiber, George J, Peterse, Johannes L, Roberts, Chris, Marton, Matthew J, Parrish, Mark, Atsma, Douwe, Witteveen, Anke, Glas, Annuska, Delahaye, Leonie, van der Velde, Tony, Bartelink, Harry, Rodenhuis, Sjoerd, Rutgers, Emiel T, Friend, Stephen H, Bernards, René

“…The patterns of expression of 70 genes in almost 300 breast-cancer specimens revealed two genetic signatures: one correlated with a good prognosis, and the…”
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Gene expression profiling predicts clinical outcome of breast cancer by Friend, Stephen H, van 't Veer, Laura J, Dai, Hongyue, van de Vijver, Marc J, He, Yudong D, Hart, Augustinus A. M, Mao, Mao, Peterse, Hans L, van der Kooy, Karin, Marton, Matthew J, Witteveen, Anke T, Schreiber, George J, Kerkhoven, Ron M, Roberts, Chris, Linsley, Peter S, Bernards, René

“…Breast cancer patients with the same stage of disease can have markedly different treatment responses and overall outcome. The strongest predictors for…”
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